Zobrazeno 1 - 10
of 77
pro vyhledávání: '"James L. Quinn"'
Autor:
Agnieshka M. Agasing, Qi Wu, Bhuwan Khatri, Nadja Borisow, Klemens Ruprecht, Alexander Ulrich Brandt, Saurabh Gawde, Gaurav Kumar, James L. Quinn, Rose M. Ko, Yang Mao-Draayer, Christopher J. Lessard, Friedemann Paul, Robert C. Axtell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Type I IFN has apposing effects in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Here the authors perform molecular profiling of NMOSD patients and mouse mechanistic experiments of neuro-inflammation to show that IFN-I s
Externí odkaz:
https://doaj.org/article/7b8aeab093224a3480c864d3e07e1bf6
Publikováno v:
Cells, Vol 10, Iss 8, p 2139 (2021)
Interferon (IFN)-β is a popular therapy for multiple sclerosis (MS). However, 25–40% of patients are nonresponsive to this therapy, and it worsens neuromyelitis optica (NMO), another neuroinflammatory disease. We previously identified, in both NMO
Externí odkaz:
https://doaj.org/article/2b7cac38e6164d02bd35508672d084a7
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Both T cells and B cells are implicated in the pathology of multiple sclerosis (MS), but how these cells cooperate to drive disease remains unclear. Recent studies using experimental autoimmune encephalomyelitis (EAE) demonstrated that the TH17 pathw
Externí odkaz:
https://doaj.org/article/6229e67bafb04241abdf7f6aa9939789
Autor:
Saurabh Gawde, Alexander U. Brandt, James L. Quinn, Klemens Ruprecht, Agnieshka M. Agasing, Christopher J. Lessard, Yang Mao-Draayer, Nadja Borisow, Bhuwan Khatri, Qi Wu, Gaurav Kumar, Friedemann Paul, Robert C. Axtell, Rose M. Ko
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Type I interferon (IFN-I) and T helper 17 (TH17) drive pathology in neuromyelitis optica spectrum disorder (NMOSD) and in TH17-induced experimental autoimmune encephalomyelitis (TH17-EAE). This is paradoxical because the prevalent theory is that IFN-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273c5641e5cb0e41b4ad8889f63cc1ed
http://link.springer.com/article/10.1038/s41467-020-16625-7
http://link.springer.com/article/10.1038/s41467-020-16625-7
Autor:
Kanneboyina Nagaraju, Qi Long Lu, Melissa Morales, Yetrib Hathout, Umar Burki, James S. Novak, Aiping Zhang, Terence A. Partridge, Katie A. Edwards, Kathleen Tatum, Eric P. Hoffman, Margaret Benny Klimek, Jack H. Van der Mulen, James L Quinn, Alyson A. Fiorillo, John van den Anker, Volker Straub, Maria Candida Vila, Jessica F. Boehler
Publikováno v:
Journal of neuromuscular diseases. 8(s2)
Background: Phosphorodiamidate morpholino oligomer (PMO)-mediated exon skipping is currently used in clinical development to treat Duchenne muscular dystrophy (DMD), with four exon-skipping drugs achieving regulatory approval. Exon skipping elicits a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6be1d995f90f46a27d768d47909c46d
https://pubmed.ncbi.nlm.nih.gov/34569970
https://pubmed.ncbi.nlm.nih.gov/34569970
Publikováno v:
Cells
Volume 10
Issue 8
Cells, Vol 10, Iss 2139, p 2139 (2021)
Volume 10
Issue 8
Cells, Vol 10, Iss 2139, p 2139 (2021)
Interferon (IFN)-β is a popular therapy for multiple sclerosis (MS). However, 25–40% of patients are nonresponsive to this therapy, and it worsens neuromyelitis optica (NMO), another neuroinflammatory disease. We previously identified, in both NMO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74a1f6bd1fd85b977cc61774a682b90
http://europepmc.org/articles/PMC8392231
http://europepmc.org/articles/PMC8392231
Publikováno v:
ImmunoHorizons
The CD1d-binding glycolipid α-galactosylceramide (α-GC) is a potent adjuvant that activates NKT cells and in turn enhances T-dependent humoral immunity. Very little is known about how NKT cells and the NKT follicular helper (NKTfh) subset influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4878db7779a628be69d81524763946e5
https://doi.org/10.4049/immunohorizons.1800081
https://doi.org/10.4049/immunohorizons.1800081
Autor:
Rose M. Ko, Robert C. Axtell, Agnieshka Agasing, Gaurav Kumar, James L. Quinn, Scott S. Zamvil, Zahra Maria, Uday Kohli
Publikováno v:
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
article-version (Version of Record) 3
ObjectiveB cells have emerged as a therapeutic target for MS. Anti-CD20 antibodies, which deplete B cells, are effective therapies for MS. However, atacicept (TACI-Fc), which blocks BAFF and APRIL and reduces B cells, unexpectedly exacerbates MS. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9948b2d1db9e36fa6d957b7570f57991
https://doi.org/10.1212/nxi.0000000000000973
https://doi.org/10.1212/nxi.0000000000000973
Autor:
Robert C. Axtell, James L. Quinn
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3233 (2018)
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3233 (2018)
Multiple sclerosis (MS) is an autoimmune disorder where both T cells and B cells are implicated in pathology. However, it remains unclear how these two distinct populations cooperate to drive disease. There is ample evidence from studies in both MS p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41474f2d581b5410c5f1143095b193e
http://europepmc.org/articles/PMC6214126
http://europepmc.org/articles/PMC6214126
Autor:
Laurent P. Bogdanik, James S. Novak, Jack H. Van der Meulen, Allison Saunders, Whitney Andrews, William Coley, Gregory A. Cox, Catherine Lammert, Terence A. Partridge, Connor P. Dolan, Maria Candida Vila, Cathleen M. Lutz, Marie Nearing, Qing Yu, Andrew Austin, James L Quinn, Sree Rayavarapu, Kanneboyina Nagaraju
Publikováno v:
Human Molecular Genetics. 25:130-145
Genetic background significantly affects phenotype in multiple mouse models of human diseases, including muscular dystrophy. This phenotypic variability is partly attributed to genetic modifiers that regulate the disease process. Studies have demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93edaf24d03d8e8b655942da2c531cf6
https://doi.org/10.1093/hmg/ddv460
https://doi.org/10.1093/hmg/ddv460