Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James L. Mobley"'
Autor:
Michael J. Ford, Richard Jones, Ravi Amunugama, David Allen, Michael Pisano, James L. Mobley, Paul Domanski, Daniel Bochar
Publikováno v:
The Journal of Immunology. 200:99.13-99.13
The major histocompatibility complex (MHC) is a region of highly polymorphic genes encoding for glycoproteins (MHC molecules) that form part of the cell-mediated branch of the acquired immune system. In the cytosol, cellular self and foreign (non-sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f059f0707e1b0621c535a291977698
https://doi.org/10.4049/jimmunol.200.supp.99.13
https://doi.org/10.4049/jimmunol.200.supp.99.13
Autor:
Steven J. Madore, James L. Mobley, Richard Renkiewicz, Michael T. Leininger, Theodore J. Baginski
Publikováno v:
Inflammation. 30:189-197
Human peripheral blood monocytes are found as two distinct populations based upon differential expression of chemokine receptors, adhesion molecules, Fc receptors, and cytokines. cDNA microarray analysis now reveals additional differences between the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2629732810854a63ea1a06ff91031338
https://doi.org/10.1007/s10753-007-9036-0
https://doi.org/10.1007/s10753-007-9036-0
Autor:
Keri Lynn Greene, Melean Visnick, Christine Nylund Kolz, James L. Mobley, Thomas B. Lanni, Kimberly Suzanne Para, Theodore J. Baginski, Marya Liimatta, David T. Dudley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:756-760
The Type 1 PI3Kinases comprise a family of enzymes, which primarily phosphorylate PIP2 to give the second messenger PIP3, a key player in many intracellular signaling processes [Science, 2002, 296, 1655; Trends Pharmacol. Sci.2003, 24, 366]. Of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55faf0e5a4fa2a28b12b65908f21ca2f
https://doi.org/10.1016/j.bmcl.2006.10.080
https://doi.org/10.1016/j.bmcl.2006.10.080
Autor:
David T. Dudley, Haile Tecle, James L. Mobley, Denis J. Schrier, Stephen Douglas Barrett, Melissa Thiel, Craig M. Flory, Caralee J. Schaefer, Mark E. Lesch
Publikováno v:
Arthritis & Rheumatism. 56:3347-3357
Objective To evaluate the role of the MEK/ERK MAP kinase pathway in murine collagen-induced arthritis (CIA) using the selective MEK inhibitor PD184352. We examined the effects of the inhibitor in cytokine-stimulated synovial fibroblasts and in cytoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6379e3e31057652f698f56a47953206c
https://doi.org/10.1002/art.22869
https://doi.org/10.1002/art.22869
Autor:
James L. Mobley
Publikováno v:
Drug Discovery Today. 11:4-7
Epidemiological and archaeological evidence suggests that RA could be a consequence of enhanced immunity to Mycobacterium tuberculosis, and that by understanding this connection, new RA drug targets may be uncovered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc49fff1562c544b9f7dd6b22d5a1dd
https://doi.org/10.1016/s1359-6446(05)03627-5
https://doi.org/10.1016/s1359-6446(05)03627-5
Publikováno v:
The Journal of Immunology. 198:75.18-75.18
Protein arginine deiminase (PAD) enzymes and the arginine to citrulline reaction that they catalyze have increased in prominence in recent years, as dysregulation is associated with multiple inflammatory and autoimmune diseases. Under normal circumst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea78e0ce91477bc66676404d059e759c
https://doi.org/10.4049/jimmunol.198.supp.75.18
https://doi.org/10.4049/jimmunol.198.supp.75.18
Publikováno v:
The Journal of Immunology. 162:5592-5600
Animal models of allergic lung inflammation have provided important insight into the cellular and biochemical factors involved in the pathogenesis of human asthma. Herein, we describe an adoptive transfer model of OVA-specific eosinophilic lung infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c885d1152c7bc1fa83efb0fc933e75f
https://doi.org/10.4049/jimmunol.162.9.5592
https://doi.org/10.4049/jimmunol.162.9.5592
Autor:
Traci Zell, Wendy J. Kivens, Cheryl L. Dell, James L. Mobley, Barbara E. Bierer, Stephen W. Hunt, Yoji Shimizu
Publikováno v:
Molecular and Cellular Biology. 18:5291-5307
The CD2 molecule is one of several lymphocyte receptors that rapidly initiates signaling events regulating integrin-mediated cell adhesion. CD2 stimulation of resting human T cells results within minutes in an increase in beta1-integrin-mediated adhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad3f43110e65c853d87b432cf1851ce
https://doi.org/10.1128/mcb.18.9.5291
https://doi.org/10.1128/mcb.18.9.5291
Publikováno v:
Expert Opinion on Investigational Drugs. 6:1-6
Eosinophils and mast cells have long been considered as the major effector cells ultimately responsible for bronchial obstruction and airway hyper-responsiveness in asthmatics. However, there is now accumulating evidence that products of Th2 lymphocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ef2935e841aa59323b361cf86fa717
https://doi.org/10.1517/13543784.6.1.1
https://doi.org/10.1517/13543784.6.1.1
Publikováno v:
Expert Opinion on Investigational Drugs. 5:871-884
Glucocorticoids are the most efficacious agents currently available for the treatment of asthma. This review highlights some of the known mechanisms of glucocorticoid function, discusses possible cellular targets for glucocorticoid anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f669db7b8a127253dfc3c2778adc1d0
https://doi.org/10.1517/13543784.5.7.871
https://doi.org/10.1517/13543784.5.7.871