Zobrazeno 1 - 10
of 329
pro vyhledávání: '"James L. Manley"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 25-35 (2024)
Transcripts from the human WDR33 gene, which encodes a central component of the mRNA polyadenylation (PA) machinery, are subject to alternative polyadenylation (APA) within promoter-proximal introns/exons. This APA, which itself involves usage of mul
Externí odkaz:
https://doaj.org/article/9ddde494993f4a488ef3ee4925eaf08e
Autor:
Lizhi Liu, James L. Manley
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113886- (2024)
Summary: The human WDR33 gene encodes three major isoforms. The canonical isoform WDR33v1 (V1) is a well-characterized nuclear mRNA polyadenylation factor, while the other two, WDR33v2 (V2) and WDR33v3 (V3), have not been studied. Here, we report tha
Externí odkaz:
https://doaj.org/article/e624fe017d774d118fd617ac6f2383c1
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Fused in Sarcoma (FUS) is a nuclear RNA/DNA binding protein that mislocalizes to the cytoplasm in the neurodegenerative diseases ALS and FTD. Despite the existence of FUS pathogenic mutations that result in nuclear import defects, a subset o
Externí odkaz:
https://doaj.org/article/15b1d8fd15584c649fa05ed7373b2fcd
Autor:
Larry C. Cheng, Dinghai Zheng, Erdene Baljinnyam, Fangzheng Sun, Koichi Ogami, Percy Luk Yeung, Mainul Hoque, Chi-Wei Lu, James L. Manley, Bin Tian
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.
Externí odkaz:
https://doaj.org/article/930e44d8511440f79f4ea3c291ee5bb2
Autor:
Bettina Drisaldi, Luca Colnaghi, Luana Fioriti, Nishta Rao, Cory Myers, Anna M. Snyder, Daniel J. Metzger, Jenna Tarasoff, Edward Konstantinov, Paul E. Fraser, James L. Manley, Eric R. Kandel
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1694-1702 (2015)
Protein synthesis is crucial for the maintenance of long-term-memory-related synaptic plasticity. The prion-like cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regulates the translation of several mRNAs important for long-term synaptic
Externí odkaz:
https://doaj.org/article/1576dc630f3b431dba4f5d34a1b78048
Autor:
Dennis Lazarev, Rachel L. Miller, Emily Dimango, Xian-Dong Fu, Hai-Ri Li, Charlotte J. Logan, James L. Manley
Publikováno v:
Genomics Data, Vol 2, Iss C, Pp 99-104 (2014)
Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Asperg
Externí odkaz:
https://doaj.org/article/8cf8adb611974144821cc460181e02fe
Publikováno v:
Non-Coding RNA, Vol 4, Iss 1, p 8 (2018)
The nuclear RNA exosome is an essential and versatile machinery that regulates maturation and degradation of a huge plethora of RNA species. The past two decades have witnessed remarkable progress in understanding the whole picture of its RNA substra
Externí odkaz:
https://doaj.org/article/958311400efb4666ae751e4b40907484
Autor:
In Young Choi, Jonathan P. Ling, Jian Zhang, Eric Helmenstine, Wencke Walter, Riley E. Bergman, Céline Philippe, James L. Manley, Kevin Rouault-Pierre, Bing Li, Daniel H. Wiseman, Madhu Ouseph, Elsa Bernard, Xiao Li, Torsten Haferlach, Salman Fazal, Tania Jain, Christopher D. Gocke, Amy E. DeZern, W. Brian Dalton
Among the most common genetic alterations in the myelodysplastic syndromes (MDS) are mutations in the spliceosome gene SF3B1. Such mutations induce specific RNA missplicing events, directly promote ring sideroblast (RS) formation, generally associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c37754f0a305035e47a2a1f7e762c56
https://doi.org/10.21203/rs.3.rs-2802265/v1
https://doi.org/10.21203/rs.3.rs-2802265/v1
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Certain long non-coding RNAs (lncRNAs) are known to contain small open reading frames that can be translated. Here we describe a much larger 25 kDa human protein, “ R ibosomal I GS E ncoded P rotein” (RIEP), that remarkably is encoded by the well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c0d29607be7ac69d741518f9f929790
https://doi.org/10.1073/pnas.2221109120
https://doi.org/10.1073/pnas.2221109120
Autor:
Shuang Feng, James L. Manley
Publikováno v:
Genesdevelopment. 36(15-16)
Nucleoli are the major cellular compartments for the synthesis of rRNA and assembly of ribosomes, the macromolecular complexes responsible for protein synthesis. Given the abundance of ribosomes, there is a huge demand for rRNA, which indeed constitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52bacef7749c2941216f585f1aa2717
https://pubmed.ncbi.nlm.nih.gov/36207140
https://pubmed.ncbi.nlm.nih.gov/36207140