Zobrazeno 1 - 10
of 159
pro vyhledávání: '"James L. Leighton"'
Autor:
Linda M. Suen, Makeda A. Tekle-Smith, Kevin S. Williamson, Joshua R. Infantine, Samuel K. Reznik, Paul S. Tanis, Tyler D. Casselman, Dan L. Sackett, James L. Leighton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Step-economical and efficient syntheses of Spongistatin 1 analogs are desirable for the development of potent anti-proliferative agents. Here, the authors report a 22-step synthesis of a D-ring modified Spongistatin 1 analog with retained picomolar p
Externí odkaz:
https://doaj.org/article/9cd90a1f6e3547f381fa06dc5d3b6186
Publikováno v:
Organic Letters. 19:6024-6027
A direct, mild, and general method for the enantioselective allylsilylation of aldehydes with allyl chlorides is reported. The reactions are effectively catalyzed by 5 mol % of n-Bu4NBr, and this rate acceleration allows the use of complex allyl dono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580ac9da9fb4c2280ba14ed643e520a9
https://doi.org/10.1021/acs.orglett.7b03193
https://doi.org/10.1021/acs.orglett.7b03193
Publikováno v:
ACS Medicinal Chemistry Letters. 8:701-704
An approach to the validation of a linker strategy for the epothilone family of microtubule-stabilizing agents is reported. An analogue of epothilone B in which the C(6) methyl group has been replaced with a 4-azidobutyl group has been prepared by to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9471900b4f62d17c566ef5673cc499
https://doi.org/10.1021/acsmedchemlett.7b00131
https://doi.org/10.1021/acsmedchemlett.7b00131
Autor:
Latha Venkataraman, Madhav Neupane, Timothy A. Su, Michael L. Steigerwald, Rebekka S. Klausen, Haixing Li, Nathaniel T. Kim, James L. Leighton, Colin Nuckolls
Publikováno v:
Accounts of Chemical Research. 50:1088-1095
This Account provides an overview of our recent efforts to uncover the fundamental charge transport properties of Si-Si and Ge-Ge single bonds and introduce useful functions into group 14 molecular wires. We utilize the tools of chemical synthesis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbb8fb7085f77640237edae4d29c593
https://doi.org/10.1021/acs.accounts.7b00059
https://doi.org/10.1021/acs.accounts.7b00059
Publikováno v:
Journal of the American Chemical Society. 139:4568-4573
Because of both their synthetically challenging and stereochemically complex structures and their wide range of often clinically relevant biological activities, nonaromatic polyketide natural products have for decades attracted an enormous amount of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874362a52125d1072f26fb61b5e8e746
https://doi.org/10.1021/jacs.7b01590
https://doi.org/10.1021/jacs.7b01590
Autor:
Kevin S. Williamson, Makeda A. Tekle-Smith, Paul S. Tanis, Dan L. Sackett, Tyler D. Casselman, Joshua R. Infantine, Samuel K. Reznik, James L. Leighton, Linda M. Suen
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Spongistatin 1 is among the most potent anti-proliferative agents ever discovered rendering it an attractive candidate for development as a payload for antibody–drug conjugates and other targeted delivery approaches. Unfortunately, it is unavailabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffc099b35732c727a80ca2044843c2b
http://europepmc.org/articles/PMC6226463
http://europepmc.org/articles/PMC6226463
Autor:
Corinne N. Foley, James L. Leighton
Publikováno v:
Organic Letters
An efficient, step-economical, and scalable approach to the synthesis of polypropionate stereotriads has been developed. Either 2-butyne or propyne is subjected to rhodium-catalyzed silylformylation and in situ crotylation of the resulting aldehydes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b62439b43322486c5b7ec3a0277f2fb
https://doi.org/10.1021/ol500051e
https://doi.org/10.1021/ol500051e
Publikováno v:
Journal of the American Chemical Society. 138(36)
A highly conducting electronic contact between a strained disilane and Au is demonstrated through scanning tunneling microscope-based single-molecule measurements. Conformationally locked cis diastereomers of bis(sulfide)-anchor-equipped 1,2-disilaac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bea457122da70161f8153734b66cac
https://pubmed.ncbi.nlm.nih.gov/27563932
https://pubmed.ncbi.nlm.nih.gov/27563932
Publikováno v:
Journal of the American Chemical Society. 133:7308-7311
A highly efficient and step-economical synthesis of zincophorin methyl ester has been achieved. The unprecedented step economy of this zincophorin synthesis is principally due to an application of the tandem silylformylation-crotylsilylation/Tamao ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e4e71a9d94614eb863792c06ed435d
https://doi.org/10.1021/ja201467z
https://doi.org/10.1021/ja201467z
Autor:
Ambica Parmar, Camille J. Olechowski, Bradley J. Kerr, Gustavo Tenorio, Jared Stephan, James L. Leighton, Brooke Miller, Kristy Tran
Publikováno v:
Pain. 149:565-572
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which neuropathic pain is now recognized as a major symptom. To date, few studies have examined the underlying mechanisms of neuropathic pain in M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f996d13df0d74080102767db622a2b
https://doi.org/10.1016/j.pain.2010.03.037
https://doi.org/10.1016/j.pain.2010.03.037