Zobrazeno 1 - 10
of 30
pro vyhledávání: '"James L. Kirk"'
Autor:
Milena Silva, David A. Wacker, Brian E. Driver, Abbey Staugaitis, Laura J. Niedernhofer, Elizabeth L. Schmidt, James L. Kirkland, Tamara Tchkonia, Tamara Evans, Carlos Hines Serrano, Steffen Ventz, Joseph S. Koopmeiners, Michael A. Puskarich, The STOP-Sepsis Investigators
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Senescent immune cells exhibit altered gene expression and resistance to apoptosis. The prevalence of these cells increases with age and emerging data implicate senescence-associated maladaptive signaling as a potential contributo
Externí odkaz:
https://doaj.org/article/75fb6b81b5be4aa8ac501941ef1ff11d
Autor:
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Externí odkaz:
https://doaj.org/article/67f438cf2e6642df8392e5f12d364395
Autor:
Nadia Akhiyat, Ilke Ozcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L. Kirkland, Bradley Lewis, Lilach O. Lerman, Amir Lerman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Coronary microvascular dysfunction (CMD) represents an early functional characteristic of coronary vascular aging. Klotho (α‐klotho) is a circulating protein inversely linked to physiological aging. We examined low klotho as a potential
Externí odkaz:
https://doaj.org/article/5c480bf7ab324712a8b5e2e9cefc6d3a
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Bryan J. Neth, Ian E. Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A. Mansour, Bipasha Mukherjee, Arthur E. Warrington, Susan C. Short, Thomas von Zglinicki, Desmond A. Brown, Sandeep Burma, Tamar Tchkonia, Marissa J. Schafer, Darren J. Baker, Sani H. Kizilbash, James L. Kirkland, Terry C. Burns
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent gl
Externí odkaz:
https://doaj.org/article/c015455051d141358c38ab0af93970d0
Autor:
Yves Rolland, Felipe Sierra, Luigi Ferrucci, Nir Barzilai, Rafael De Cabo, Joan Mannick, Anthony Oliva, William Evans, Davide Angioni, Philipe De Souto Barreto, Jeremy Raffin, Bruno Vellas, James L. Kirkland, the G.C.T-TF group
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Geroscience is becoming a major hope for preventing age-related diseases and loss of function by targeting biological mechanisms of aging. This unprecedented paradigm shift requires optimizing the design of future clinical studies related to
Externí odkaz:
https://doaj.org/article/eb01587548254b758eb55498e901135e
Autor:
Xiaoyu Ma, Yingyi Zhang, Yuanyuan Zhang, Xu Zhang, Yan Huang, Kai He, Chuan Chen, Jielu Hao, Debiao Zhao, Nathan K. LeBrasseur, James L. Kirkland, Eduardo N. Chini, Qing Wei, Kun Ling, Jinghua Hu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells. Fbf1 ablation reduces senescence and associated health decline in mice, highlighting cil
Externí odkaz:
https://doaj.org/article/880ce8033dc74d578533b640039e7438
Autor:
Areez Shafqat, Saifullah Khan, Mohamed H. Omer, Mahnoor Niaz, Ibrahem Albalkhi, Khaled AlKattan, Ahmed Yaqinuddin, Tamara Tchkonia, James L. Kirkland, Shahrukh K. Hashmi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, the impact o
Externí odkaz:
https://doaj.org/article/519caf32eebf4c0c9b2adc814246fd4e
Autor:
Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga, Jasmin Kuo, Tamara Tchkonia, James L. Kirkland, Thomas G. Travison, Lewis A. Lipsitz
Publikováno v:
Translational Medicine of Aging, Vol 7, Iss , Pp 109-117 (2023)
The process of cellular senescence is hypothesized to play a critical role in the development of age-related mobility and cognitive impairments, both of which precede the development of Alzheimer's disease. Therefore, senolytic compounds that elimina
Externí odkaz:
https://doaj.org/article/58c2ad81fc9b463a88dad1f0ad2daa37
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
Externí odkaz:
https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Autor:
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, João F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
Externí odkaz:
https://doaj.org/article/e07e402c5be742719a9abae3ab241ab2