Zobrazeno 1 - 10
of 19
pro vyhledávání: '"James L. Engel"'
Autor:
Konstantina-Ioanna Sereti, Ngoc B. Nguyen, Paniz Kamran, Peng Zhao, Sara Ranjbarvaziri, Shuin Park, Shan Sabri, James L. Engel, Kevin Sung, Rajan P. Kulkarni, Yichen Ding, Tzung K. Hsiai, Kathrin Plath, Jason Ernst, Debashis Sahoo, Hanna K.A. Mikkola, M. Luisa Iruela-Arispe, Reza Ardehali
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
During cardiac tissue formation it is unclear whether newly generated myocytes originate from cardiac progenitor cells or from pre-existing cardiomyocytes. Here, the authors use a stochastic four-colour reporter system (Rainbow) to identify the sourc
Externí odkaz:
https://doaj.org/article/c802b51efbb94834a80f05d3baafd799
Autor:
James L. Engel, Reza Ardehali
Publikováno v:
Stem Cells International, Vol 2018 (2018)
The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac function after insult; thus, the ability to regenerate and repair the injured myocardium remains a top priority in treating heart failure. The ability to effici
Externí odkaz:
https://doaj.org/article/f443b18c206e4fae86717ae8262fe331
Autor:
Rong Qiao, Ngoc B. Nguyen, Peng Zhao, David A. Elliott, W Blake Gilmore, Arash Pezhouman, Debashis Sahoo, James L. Engel, Reza Ardehali, Rhys J.P. Skelton
Publikováno v:
Cardiovasc Res
Aims We prospectively isolate and characterize first and second heart field- and nodal-like cardiomyocytes using a double reporter line from human embryonic stem cells. Our double reporter line utilizes two important transcription factors in cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539ba0119e015969499109e61ebc274e
https://doi.org/10.1093/cvr/cvab102
https://doi.org/10.1093/cvr/cvab102
Autor:
Kevin Sung, Sara Ranjbarvaziri, Tzung K. Hsiai, Jason Ernst, Shuin Park, Rajan P. Kulkarni, Hanna K. A. Mikkola, Yichen Ding, Konstantina Ioanna Sereti, Kathrin Plath, Peng Zhao, Reza Ardehali, Shan Sabri, M. Luisa Iruela-Arispe, Debashis Sahoo, James L. Engel, Ngoc B. Nguyen, Paniz Kamran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sereti, Konstantina-Ioanna; Nguyen, Ngoc B; Kamran, Paniz; Zhao, Peng; Ranjbarvaziri, Sara; Park, Shuin; et al.(2018). Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. NATURE COMMUNICATIONS, 9(1), 754. doi: 10.1038/s41467-018-02891-z. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/5241d41s
Nature Communications
Nature communications, vol 9, iss 1
Sereti, Konstantina-Ioanna; Nguyen, Ngoc B; Kamran, Paniz; Zhao, Peng; Ranjbarvaziri, Sara; Park, Shuin; et al.(2018). Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. NATURE COMMUNICATIONS, 9(1), 754. doi: 10.1038/s41467-018-02891-z. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/5241d41s
Nature Communications
Nature communications, vol 9, iss 1
The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01383c48cf960ac409ae380421772e1
https://doaj.org/article/c802b51efbb94834a80f05d3baafd799
https://doaj.org/article/c802b51efbb94834a80f05d3baafd799
Autor:
Nicholas Hornstein, Ngoc B. Nguyen, Arash Pezhouman, James L. Engel, Rhys J.P. Skelton, Reza Ardehali, Blake W Gilmore, Peng Zhao
Publikováno v:
Circulation Research. 125
Cardiovascular disease (CVD) is the leading cause of death worldwide. Human embryonic stem cell (hESC)-derived cardiovascular progenitors (CVPs) or cardiomyocytes (CMs) represent a promising candidate for cell-based therapies to treat CVD. Myocardial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76beaf1fa9ec22feb89437d1d52f255e
https://doi.org/10.1161/res.125.suppl_1.145
https://doi.org/10.1161/res.125.suppl_1.145
Autor:
Jianzhong Wen, Lorenzo A. Pinna, Eric Durrant, Junyu Xiao, Kim B. Nguyen, Jixin Cui, Vincent S. Tagliabracci, Lisa N. Kinch, David J. Pagliarini, Joshua J. Coon, Jack E. Dixon, Nick V. Grishin, Sandra E. Wiley, James L. Engel, Xiao Guo
Publikováno v:
Cell. 161(7):1619-1632
SummaryThe existence of extracellular phosphoproteins has been acknowledged for over a century. However, research in this area has been undeveloped largely because the kinases that phosphorylate secreted proteins have escaped identification. Fam20C i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4ee639979305d51e6cc381cca55012
Autor:
Edouard G. Stanley, Oscar J. Abilez, Rhys J.P. Skelton, David A. Elliott, Murray Kwon, Andrew G. Elefanty, Reza Ardehali, Deevina Arasaratnam, Bevin Brady, Debashis Sahoo, Kholoud K. Saleh, James L. Engel, Suhail Khoja, Peng Zhao
Publikováno v:
Skelton, RJP; Brady, B; Khoja, S; Sahoo, D; Engel, J; Arasaratnam, D; et al.(2016). CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells. Stem Cell Reports, 6(1), 95-108. doi: 10.1016/j.stemcr.2015.11.006. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3h0177zq
Stem cell reports, vol 6, iss 1
Stem Cell Reports, Vol 6, Iss 1, Pp 95-108 (2016)
Stem Cell Reports
Stem cell reports, vol 6, iss 1
Stem Cell Reports, Vol 6, Iss 1, Pp 95-108 (2016)
Stem Cell Reports
Summary The generation of tissue-specific cell types from human embryonic stem cells (hESCs) is critical for the development of future stem cell-based regenerative therapies. Here, we identify CD13 and ROR2 as cell-surface markers capable of selectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b35581d629bb94db2d6dd940fc2c3ca
http://www.escholarship.org/uc/item/3h0177zq
http://www.escholarship.org/uc/item/3h0177zq
Publikováno v:
Proceedings of the National Academy of Sciences. 108:11860-11865
PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. We recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f3d113551a09262105860fe48898c5
https://doi.org/10.1073/pnas.1109290108
https://doi.org/10.1073/pnas.1109290108
Autor:
James L. Engel, Reza Ardehali
Publikováno v:
Stem Cell Investigation. 5:37-37
Affecting over 38 million people worldwide, heart failure remains an immense challenge in health care (1). The pathology of heart failure involves death or dysfunction of cardiomyocytes and replacement with non-contractile scar tissue since the adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13849ee004e113b1b8dac170e61dd013
https://doi.org/10.21037/sci.2018.10.02
https://doi.org/10.21037/sci.2018.10.02
Publikováno v:
The Journal of Biological Chemistry
Bacterial phytopathogens employ a type III secretion system to deliver effector proteins into the plant cell to suppress defense pathways; however, the molecular mechanisms and subcellular localization strategies that drive effector function largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b07c597774b82a59da2f5a7d08c724
http://europepmc.org/articles/PMC2708883
http://europepmc.org/articles/PMC2708883