Výsledky vyhledávání - "James L. Bown"

Akademický článek

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Autor: Michael A. Idowu, Hilal S Khalil, James L. Bown, Nikolai Zhelev

Publikováno v: BioDiscovery, Vol 9, Iss , Pp 1-32 (2013)

The DNA Damage Response (DDR) pathway represents a signalling mechanism that is activated in eukaryotic cells following DNA damage and comprises of proteins involved in DNA damage detection, DNA repair, cell cycle arrest and apoptosis. This pathway c

Externí odkaz: https://doaj.org/article/eeab7ab31c85464587222c36a0cf1edd

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Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Autor: Ben C. Stevenson, Peter D. Caie, Janine B. Illian, David J. Harrison, Anne Savage, Charlotte M. Jones-Todd, James L. Bown

Publikováno v: Statistics in Medicine. 38:1421-1441

Diagnosis and prognosis of cancer are informed by the architecture inherent in cancer patient tissue sections. This architecture is typically identified by pathologists, yet advances in computational image analysis facilitate quantitative assessment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a84f78a5a30c074979d6c3ff2250d040
https://doi.org/10.1002/sim.8046

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A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells

Autor: Tero Soininen, Hilal S. Khalil, David J. Harrison, Alexey Goltsov, Yusuf Y. Deeni, Simon P. Langdon, James L. Bown

Publikováno v: Oncotarget
Khalil, H S, Langdon, S, Goltsov, A, Soininen, T, Harrison, D, Bown, J & Deeni, Y 2016, ' A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells ', Oncotarget . https://doi.org/10.18632/oncotarget.12425

// Hilal S. Khalil 1 , Simon P. Langdon 3 , Alexey Goltsov 1 , Tero Soininen 1 , David J. Harrison 4 , James Bown 2 , Yusuf Y. Deeni 1 1 Division of Science, School of Science, Engineering and Technology, Abertay University, Dundee, DD1 1HG, United K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d288e62c5d3cf96b570bb22039d925
https://doi.org/10.18632/oncotarget.12425

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Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Autor: Charlotte M, Jones-Todd, Peter, Caie, Janine B, Illian, Ben C, Stevenson, Anne, Savage, David J, Harrison, James L, Bown

Publikováno v: Statistics in medicine. 38(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7d261f362b8e677b5eec2c251bb82e7
https://pubmed.ncbi.nlm.nih.gov/30488481

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Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells

Autor: Hilal S. Khalil, David J. Harrison, Simon P. Langdon, Yusuf Y. Deeni, James L. Bown, Alexey Goltsov

Publikováno v: Journal of Biotechnology. 202:12-30

Cells are constantly exposed to Reactive Oxygen Species (ROS) produced both endogenously to meet physiological requirements and from exogenous sources. While endogenous ROS are considered as important signalling molecules, high uncontrollable ROS are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3d84ab7349672d4e4761597897f6cf
https://doi.org/10.1016/j.jbiotec.2014.09.027

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Narratives for Drug Design

Autor: Alexey Goltsov, James L. Bown

Publikováno v: Narrating Complexity ISBN: 9783319647128

We explore the role of narratives of complex systems in anti-cancer drug design. We set out the value of narratives relating to cancer in promoting awareness of risky behaviour and in supporting decision-making regarding treatment options. We present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fea0373b3e34000410423bc0be0099f0
https://doi.org/10.1007/978-3-319-64714-2_18

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Nrf2 Regulates Her1 Signaling Pathway To Modulate The Sensivity Of Ovarian Cancer Cells To Lapatinib And Erlotinib

Autor: Peter R. Moult, Ibrahim H. Kankia, Simon P. Langdon, James L. Bown, Yusuf Y. Deeni, Hilal S. Khalil

Publikováno v: Kankia, I H, Langdon, S, Khalil, H S, Moult, P R, Bown, J & Deeni, Y 2017, ' Nrf2 Regulates Her1 Signaling Pathway To Modulate The Sensivity Of Ovarian Cancer Cells To Lapatinib And Erlotinib ', Oxidative Medicine and Cellular Longevity . https://doi.org/10.1155/2017/1864578
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)

NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cae1f8bea0aff20028b6091cead2b6
https://hdl.handle.net/20.500.11820/eb318805-357a-4f38-b9ff-84c1a5185591

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Understanding tissue morphology: model repurposing using the CoSMoS process

Autor: Adam T. Sampson, James L. Bown, Yusuf Y. Deeni, Ye Li, Hilal S. Khalil

Publikováno v: Natural Computing. 14:109-128

We present CoSMoS as a way of structuring thinking on how to reuse parts of an existing model and simulation in a new model and its implementation. CoSMoS provides a lens through which to consider, post-implementation, the assumptions made during the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26dd435a0bd0cf78d98a9077671406ec
https://doi.org/10.1007/s11047-014-9466-1

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Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

Autor: Simon P. Langdon, James L. Bown, David J. Harrison, Ghassan Tashkandi, Alexey Goltsov

Publikováno v: Goltsov, A, Tashkandi, G, Langdon, S P, Harrison, D J & Bown, J L 2017, ' Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002 ', European Journal of Pharmaceutical Sciences, vol. 97 . https://doi.org/10.1016/j.ejps.2016.11.008

This work was supported by grants from the Northwood Trust (AG, JB), personal support to AG from Scottish Informatics and Computer Science Alliance (SICSA), and EU support for the Concerted Action CASyM (DJH). The phosphatidylinositide 3-kinases (PI3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7617f74ad4af4451569b0d52ae913c6
https://hdl.handle.net/10023/12033

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Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer

Autor: Simon P. Langdon, David J. Harrison, D. Faratian, Andrew H. Sims, James L. Bown, Alexey Goltsov, Huizhong Hu

Publikováno v: Cellular Signalling. 25:26-32

Although the theoretical possibility of oscillations in MAPK signalling has long been described, experimental validation has proven more elusive. In this study we observed oscillations in MAPK and PI3K signalling in breast cancer cells in response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccd204af51f7cfd76c070dea6aafad9
https://doi.org/10.1016/j.cellsig.2012.09.014

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