Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Autor: Michael A. Idowu, Hilal S Khalil, James L. Bown, Nikolai Zhelev

Publikováno v: BioDiscovery, Vol 9, Iss , Pp 1-32 (2013)

The DNA Damage Response (DDR) pathway represents a signalling mechanism that is activated in eukaryotic cells following DNA damage and comprises of proteins involved in DNA damage detection, DNA repair, cell cycle arrest and apoptosis. This pathway c

Externí odkaz: https://doaj.org/article/eeab7ab31c85464587222c36a0cf1edd

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery : SiViT

Autor: Andrei Boiko, Mark Shovman, David J. Harrison, Peter Mullen, Paul Robertson, Alexey Goltsov, James L. Bown

Publikováno v: Oncotarget

// James L. Bown 1, 2 , Mark Shovman 2, 4 , Paul Robertson 2 , Andrei Boiko 1, 2 , Alexey Goltsov 1 , Peter Mullen 3 , David J. Harrison 3 1 School of Science, Engineering and Technology, Abertay University, Dundee, DD1 1HG, UK 2 School of Arts, Medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296c0ac94aef50a223312efb7ac01e1b
https://hdl.handle.net/10023/9005

Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Autor: Charlotte M, Jones-Todd, Peter, Caie, Janine B, Illian, Ben C, Stevenson, Anne, Savage, David J, Harrison, James L, Bown

Publikováno v: Statistics in medicine. 38(8)

Diagnosis and prognosis of cancer are informed by the architecture inherent in cancer patient tissue sections. This architecture is typically identified by pathologists, yet advances in computational image analysis facilitate quantitative assessment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7d261f362b8e677b5eec2c251bb82e7
https://pubmed.ncbi.nlm.nih.gov/30488481

Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells

Autor: Hilal S. Khalil, David J. Harrison, Simon P. Langdon, Yusuf Y. Deeni, James L. Bown, Alexey Goltsov

Publikováno v: Journal of Biotechnology. 202:12-30

Cells are constantly exposed to Reactive Oxygen Species (ROS) produced both endogenously to meet physiological requirements and from exogenous sources. While endogenous ROS are considered as important signalling molecules, high uncontrollable ROS are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3d84ab7349672d4e4761597897f6cf
https://doi.org/10.1016/j.jbiotec.2014.09.027

Nrf2 Regulates Her1 Signaling Pathway To Modulate The Sensivity Of Ovarian Cancer Cells To Lapatinib And Erlotinib

Autor: Peter R. Moult, Ibrahim H. Kankia, Simon P. Langdon, James L. Bown, Yusuf Y. Deeni, Hilal S. Khalil

Publikováno v: Kankia, I H, Langdon, S, Khalil, H S, Moult, P R, Bown, J & Deeni, Y 2017, ' Nrf2 Regulates Her1 Signaling Pathway To Modulate The Sensivity Of Ovarian Cancer Cells To Lapatinib And Erlotinib ', Oxidative Medicine and Cellular Longevity . https://doi.org/10.1155/2017/1864578
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)

NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cae1f8bea0aff20028b6091cead2b6
https://hdl.handle.net/20.500.11820/eb318805-357a-4f38-b9ff-84c1a5185591