Výsledky vyhledávání - "James L. Maggs"

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

Autor: Henry Pertinez, Munir Pirmohamed, Anthony G Marson, B. Kevin Park, Xiaoli Meng, Daniel F. Carr, James L. Maggs, Vincent Yip

Publikováno v: British Journal of Clinical Pharmacology
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Aims Carbamazepine can cause hypersensitivity reactions in ~10% of patients. An immunogenic effect can be produced by the electrophilic 10,11-epoxide metabolite but not by carbamazepine. Hypothetically, certain single nucleotide polymorphisms might i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f2db939e920c6134022bbdb20c3b12
http://europepmc.org/articles/PMC8247401

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Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo

Autor: Xiaoli Meng, Kevin Park, Jane Hamlett, James L. Maggs, John Farrell, Arun Tailor, J. C. Waddington, Paul Whitaker, Laila Kafu, Dean J. Naisbitt, Gordon J. Dear

Publikováno v: Chemical Research in Toxicology. 32:2095-2106

Hypersensitivity reactions occur frequently in patients upon treatment with sulfamethoxazole (SMX). These adverse effects have been attributed to nitroso sulfamethoxazole (SMX-NO), the reactive product formed from auto-oxidation of the metabolite SMX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db527fa8a25b01648f060fa614ef535
https://doi.org/10.1021/acs.chemrestox.9b00282

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Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors

Autor: James L. Maggs, Arun Tailor, Catherine J. Betts, Abdulaziz Alzahrani, John Farrell, J. C. Waddington, Xioali Meng, B. Kevin Park, Dean J. Naisbitt, Monday O. Ogese

Publikováno v: Chemical Research in Toxicology. 30:2174-2186

Dapsone (DDS) causes hypersensitivity reactions in 0.5-3.6% of patients. Although clinical diagnosis is indicative of a hypersensitivity reaction, studies have not been performed to define whether dapsone or a metabolite activates specific T-cells. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b17ae1b1bff43137da8f2b0cd5983e
https://doi.org/10.1021/acs.chemrestox.7b00263

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Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Autor: Christopher E. Goldring, B. Kevin Park, Jeffrey J. Sutherland, Stephen W. Fenwick, Lucille Rainbow, Amy Schofield, Bob van de Water, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Yongxiang Fang, Wouter den Hollander, James L. Stevens, Magnus Ingelman-Sundberg, Ewa Ellis, Ian M. Copple

Publikováno v: Archives of Toxicology
Archives of Toxicology, 93(2), 385-399

The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI). Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66197f0ae602e06563bec0ec31100056
https://hdl.handle.net/1887/67579

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Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

Autor: Rosalind E. Jenkins, James L. Maggs, Vincent Yip, Xiaoli Meng, B. Kevin Park, Philippe T. Marlot, Munir Pirmohamed, Anthony G Marson

Publikováno v: Chemical Research in Toxicology

Carbamazepine (CBZ) is an effective antiepileptic drug that has been associated with hypersensitivity reactions. The pathogenesis of those reactions is incompletely understood but is postulated to involve a complex interplay between the drug's metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928ce8e96e84f65fd7d153db40230f63

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Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC–MS/MS method

Autor: Daniel J. Antoine, Munir Pirmohamed, Ian D. Wilson, B. Kevin Park, James L. Maggs, Muireann Coen, Alison V. M. Rodrigues, Stephen J McWilliam

Publikováno v: Bioanalysis

Background: Mevalonic acid (MVA), as a product of 3-hydroxy-3-methylglutaryl coenzyme A reductase, represents a potential multipurpose biomarker in health and disease. A translational urinary MVA quantification method was developed, validated and use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8913fd3acdfdf10cf4a8738497d8c120
https://doi.org/10.4155/bio.13.350

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Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine

Autor: James Chadwick, B. Kevin Park, Fatima Bousejra-El Garah, James L. Maggs, Paul M. O'Neill, Jean-Luc Stigliani, Sant Muangnoicharoen, Michael H. L. Wong, Richard Amewu, Stephen A. Ward

Publikováno v: Journal of Medicinal Chemistry. 54:6443-6455

Dispiro-1,2,4,5-tetraoxanes and 1,2,4-trioxolanes represent attractive classes of synthetic antimalarial peroxides due to their structural simplicity, good stability, and impressive antimalarial activity. We investigated the reactivity of a series of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03343ecff9b3c67b3d98d64e487e0e0a
https://doi.org/10.1021/jm200768h

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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

Autor: Amy E. Mercer, Paul M. O'Neill, James L. Maggs, B. Kevin Park, Ian M. Copple

Publikováno v: Journal of Biological Chemistry; Vol 286

The artemisinin compounds are the frontline drugs for the treatment of drug-resistant malaria. They are selectively cytotoxic to mammalian cancer cell lines and have been implicated as neurotoxic and embryotoxic in animal studies. The endoperoxide fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2608103f9857e946ba6abeacedae6043
https://doi.org/10.1074/jbc.m110.144188

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Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives

Autor: Sunil Sabbani, Paul M. O'Neill, J. Luis Castrejon, Ayman Elsheikh, James L. Maggs, Dean J. Naisbitt, Sidonie N. Lavergne, B. Kevin Park, John Farrell

Publikováno v: Chemical Research in Toxicology. 23:184-192

Exposure to sulfamethoxazole (SMX) is associated with T-cell-mediated hypersensitivity reactions in human patients. T-cells can be stimulated by the putative metabolite nitroso SMX, which binds irreversibly to protein. The hydroxylamine and nitroso d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b5cd2fc660b33eee2b4a779c8d3011
https://doi.org/10.1021/tx900329b

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A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine

Autor: Rosalind E. Jenkins, B. Kevin Park, Maja Aleksic, James L. Maggs, Dean J. Naisbitt, Claire Jenkinson, Neil R. Kitteringham

Publikováno v: Chemical Research in Toxicology. 22:1172-1180

Exposure to the skin sensitizer p-phenylenediamine (PPD) is associated with allergic contact dermatitis; however, the ability of PPD to modify protein has not been fully investigated. The aims of this study were to characterize the reactions of PPD a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b870420e52e89f80c625c87a3b726d0
https://doi.org/10.1021/tx900095r

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