Výsledky vyhledávání - "James L McManaman"

Akademický článek

Autor: Kelsey E Hazegh, Travis Nemkov, Angelo D'Alessandro, John D Diller, Jenifer Monks, James L McManaman, Kenneth L Jones, Kirk C Hansen, Tânia Reis

Publikováno v: PLoS Genetics, Vol 13, Iss 6, p e1006859 (2017)

Preventing obesity requires a precise balance between deposition into and mobilization from fat stores, but regulatory mechanisms are incompletely understood. Drosophila Split ends (Spen) is the founding member of a conserved family of RNA-binding pr

Externí odkaz: https://doaj.org/article/6a6cd0dde6cc4105a00ebf6584181aaf

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Akademický článek

Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine.

Autor: Daniel N Frank, Elise S Bales, Jenifer Monks, Matthew J Jackman, Paul S MacLean, Diana Ir, Charles E Robertson, David J Orlicky, James L McManaman

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0131944 (2015)

Obesity and its co-morbidities, such as fatty liver disease, are increasingly prevalent worldwide health problems. Intestinal microorganisms have emerged as critical factors linking diet to host physiology and metabolic function, particularly in the

Externí odkaz: https://doaj.org/article/d49c0896db2e4aa08f775c588c6ab526

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Akademický článek

Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis.

Autor: Jessica L Saben, Elise S Bales, Matthew R Jackman, David Orlicky, Paul S MacLean, James L McManaman

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e98066 (2014)

Maternal metabolic and nutrient trafficking adaptations to lactation differ among lean and obese mice fed a high fat (HF) diet. Obesity is thought to impair milk lipid production, in part, by decreasing trafficking of dietary and de novo synthesized

Externí odkaz: https://doaj.org/article/c1fc1094bdcb454383c5e9c1d85703ee

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Akademický článek

Dynamic regulation of hepatic lipid droplet properties by diet.

Autor: Amanda E Crunk, Jenifer Monks, Aya Murakami, Matthew Jackman, Paul S Maclean, Mark Ladinsky, Elise S Bales, Shannon Cain, David J Orlicky, James L McManaman

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e67631 (2013)

Cytoplasmic lipid droplets (CLD) are organelle-like structures that function in neutral lipid storage, transport and metabolism through the actions of specific surface-associated proteins. Although diet and metabolism influence hepatic CLD levels, ho

Externí odkaz: https://doaj.org/article/6aee8997dce543e3bd1d5d247608a1fc

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Akademický článek

Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion.

Autor: David J Orlicky, Jenifer Monks, Adrianne L Stefanski, James L McManaman

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66837 (2013)

Perilipin-1 (Plin1), a prominent cytoplasmic lipid droplet (CLD) binding phosphoprotein and key physiological regulator of triglyceride storage and lipolysis in adipocytes, is thought to regulate the fragmentation and dispersion of CLD that occurs in

Externí odkaz: https://doaj.org/article/0e76614b1a7f4e6ba766cd00a0691879

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Akademický článek

Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion

Autor: Jayne F. Martin Carli, Monika Dzieciatkowska, Teri L. Hernandez, Jenifer Monks, James L. McManaman

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Introduction: Human milk delivers critical nutritional and immunological support to human infants. Milk fat globules (MFGs) and their associated membranes (MFGMs) contain the majority of milk lipids and many bioactive components that contribute to ne

Externí odkaz: https://doaj.org/article/d61c911580294b00a489330831721a4c

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