Zobrazeno 1 - 10
of 105
pro vyhledávání: '"James L Funderburgh"'
Autor:
Gary Hin-Fai Yam, Tianbing Yang, Moira L Geary, Mithun Santra, Martha Funderburgh, Elizabeth Rubin, Yiqin Du, Jose A Sahel, Vishal Jhanji, James L Funderburgh
Publikováno v:
Journal of Advanced Research, Vol 45, Iss , Pp 141-155 (2023)
Introduction: Corneal blindness due to scarring is treated with corneal transplantation. However, a global problem is the donor material shortage. Preclinical and clinical studies have shown that cell-based therapy using corneal stromal stem cells (C
Externí odkaz:
https://doaj.org/article/5b9861b24c7f4e1385e9d790328a6fb3
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169504 (2017)
The worldwide need for human cornea equivalents continues to grow. Few clinical options are limited to allogenic and synthetic material replacements. We hypothesized that tissue engineered human cornea systems based on mechanically robust, patterned,
Externí odkaz:
https://doaj.org/article/0f1c2ace3a074e888b8b3e2876815025
Autor:
Andrew J Hertsenberg, Golnar Shojaati, Martha L Funderburgh, Mary M Mann, Yiqin Du, James L Funderburgh
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0171712 (2017)
Corneal scarring limits vision for millions of individuals worldwide. Corneal transplantation (keratoplasty) is the standard of care for corneal opacity; however, it bears the risk of graft rejection and infection and is not universally available. St
Externí odkaz:
https://doaj.org/article/833a1fe425cf4a0986a9fb18d36b2c9d
Autor:
Dimitrios Karamichos, Martha L Funderburgh, Audrey E K Hutcheon, James D Zieske, Yiqin Du, Jian Wu, James L Funderburgh
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86260 (2014)
Human corneal fibroblasts (HCF) and corneal stromal stem cells (CSSC) each secrete and organize a thick stroma-like extracellular matrix in response to different substrata, but neither cell type organizes matrix on tissue-culture polystyrene. This st
Externí odkaz:
https://doaj.org/article/4f22a287093149a5b9ae17010254e9ec
Autor:
Audrey A Chan, Andrew J Hertsenberg, Martha L Funderburgh, Mary M Mann, Yiqin Du, Katherine A Davoli, Jocelyn Danielle Mich-Basso, Lei Yang, James L Funderburgh
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56831 (2013)
Corneal transparency depends on a unique extracellular matrix secreted by stromal keratocytes, mesenchymal cells of neural crest lineage. Derivation of keratocytes from human embryonic stem (hES) cells could elucidate the keratocyte developmental pat
Externí odkaz:
https://doaj.org/article/694244ba7db04016a18a5aa788c26942
Autor:
Rachelle N. Palchesko, Yiqin Du, Moira L. Geary, Santiago Carrasquilla, Daniel J. Shiwarski, Irona Khandaker, James L. Funderburgh, Adam W. Feinberg
Publikováno v:
Communications Materials. 3
Cell injection is a common clinical approach for therapeutic delivery into diseased and damaged tissues in order to achieve regeneration. However, cell retention, viability, and engraftment at the injection site have generally been poor, driving the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86fe8f6b87c937bffa164fa2eb3c149f
https://doi.org/10.1038/s43246-022-00247-1
https://doi.org/10.1038/s43246-022-00247-1
Autor:
Carrasquilla S, Yiqin Du, James L. Funderburgh, Rachelle N. Palchesko, Adam W. Feinberg, Irona Khandaker, Moira L. Geary, Daniel J. Shiwarski
Cell injection has emerged as a widespread approach for therapeutic delivery of healthy cells into diseased and damaged tissues to achieve regeneration. However, cell retention, viability and integration at the injection site has generally been poor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c41bc749d9afc4ea75246c1b83a33dd0
https://doi.org/10.1101/2021.03.01.433476
https://doi.org/10.1101/2021.03.01.433476
Autor:
Rohan Basu, Martha L. Funderburgh, Moira L. Geary, Yiqin Du, Lin Weng, Gary Hin-Fai Yam, James L. Funderburgh, Tianbing Yang, Irona Khandaker
Publikováno v:
Eye and Vision
Eye and Vision, Vol 7, Iss 1, Pp 1-14 (2020)
Eye and Vision, Vol 7, Iss 1, Pp 1-14 (2020)
Background Corneal stromal stem cells (CSSC) reduce corneal inflammation, prevent fibrotic scarring, and regenerate transparent stromal tissue in injured corneas. These effects rely on factors produced by CSSC to block the fibrotic gene expression. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f97350e0dcb200baf401585aa01d89c
https://doi.org/10.1186/s40662-020-00217-z
https://doi.org/10.1186/s40662-020-00217-z
Autor:
Martha L. Funderburgh, Gary Hin-Fai Yam, Irona Khandaker, Yiqin Du, James L. Funderburgh, Vishal Jhanji, Moira L. Geary
Publikováno v:
Exp Eye Res
Corneal opacities affect vision for millions of individuals worldwide. Fibrotic scar tissues accumulate in reaction to inflammatory responses and remain permanently in corneal stroma, and conventionally correctable only by donor corneal transplantati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98231f2dd63e3b786b9e7a5f13bba76
https://pubmed.ncbi.nlm.nih.gov/32979396
https://pubmed.ncbi.nlm.nih.gov/32979396
Autor:
Irona Khandaker, James L. Funderburgh, Kyle Sylakowski, Yiqin Du, Martha L. Funderburgh, Golnar Shojaati
Publikováno v:
Stem Cells Translational Medicine
Stem cells from human corneal stroma (CSSC) suppress corneal stromal scarring in a mouse wound-healing model and promote regeneration of native transparent tissue (PMID:25504883). This study investigated efficacy of compressed collagen gel (CCG) as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46ceff0bb59d6ced892c0ee869f5730
https://doi.org/10.1002/sctm.17-0258
https://doi.org/10.1002/sctm.17-0258