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Publikováno v:
Development. 149
Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC, can be harnessed to create
Autor:
James L C Che, Daniel Bode, Iwo Kucinski, Alyssa H Cull, Fiona Bain, Hans J Becker, Maria Jassinskaja, Melania Barile, Grace Boyd, Miriam Belmonte, Andy G X Zeng, Kyomi J Igarashi, Juan Rubio‐Lara, Mairi S Shepherd, Anna Clay, John E Dick, Adam C Wilkinson, Hiromitsu Nakauchi, Satoshi Yamazaki, Berthold Göttgens, David G Kent
Publikováno v:
EMBO reports. 23(10)
Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have achieved > 200-fold expansion of functional HSCs, but their molecular characterization has not