Zobrazeno 1 - 10
of 124
pro vyhledávání: '"James L, Wynn"'
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionSepsis is a common cause of morbidity and mortality in the neonatal intensive care unit (NICU). The frequency and severity of sepsis-associated coagulopathy as well as its relationship to illness severity are unclear.MethodsWe performed a
Externí odkaz:
https://doaj.org/article/0b7336384aec498abe21c2bf37f3c3b1
Autor:
Petek Eylul Taneri, Jamie J Kirkham, Eleanor J Molloy, Linda Biesty, Richard A Polin, James L Wynn, Barbara J Stoll, Niranjan Kissoon, Kondwani Kawaza, Mandy Daly, Aoife Branagan, Lívia Nagy Bonnard, Eric Giannoni, Tobias Strunk, Magdalena Ohaja, Kenneth Mugabe, Denise Suguitani, Fiona Quirke, Declan Devane
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295325 (2023)
Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) fo
Externí odkaz:
https://doaj.org/article/d7adef3b582741aca32a36188b4b3c3e
Autor:
Kusum Menon, MD, MSc, Luregn J. Schlapbach, MD, Samuel Akech, MBChB, MMED, Andrew Argent, MBBCh, MD, Kathleen Chiotos, MD, MSCE, Mohammod Jobayer Chisti, MBBS, MMed, PhD, Jemila Hamid, PhD, Paul Ishimine, MD, Niranjan Kissoon, MD, Rakesh Lodha, MD, Cláudio Flauzino Oliveira, MD, Mark Peters, MBChB, PhD, Pierre Tissieres, MD, PhD, R. Scott Watson, MD, MPH, Matthew O. Wiens, PharmD, PhD, James L. Wynn, MD, Lauren R. Sorce, BSN, PhD, for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine, Luregn J. Schlapbach, R. Scott Watson, Andrew Argent, Lauren R. Sorce, Elizabeth R. Alpern, Fran Balamuth, Tellen D. Bennett, Paolo Biban, Joe Carcillo, Enitan Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Idris Evans, Lu Guoping, Mark W. Hall, David Inwald, Paul Ishimine, Michael Levin, Niranjan (Tex) Kissoon, Rakesh Lodha, Kathryn Maitland, Simon Nadel, Satoshi Nakagawa, Claudio Flauzino Oliveira, Mark Peters, Adrienne G. Randolph, Suchitra Ranjit, L. Nelson Sanchez-Pinto, Halden F. Scott, Daniela Carla Souza, Paul Tissieres, Juliane Bubeck Wardenburg, Scott L. Weiss, Wilson Milton Were, Matt Wiens, James L. Wynn, Jerry J. Zimmerman
Publikováno v:
Critical Care Explorations, Vol 2, Iss 6, p e0123 (2020)
Objectives:. Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term “sepsis” in clinical practice, coding, and research. Current and
Externí odkaz:
https://doaj.org/article/696a47b9bd404f98a5cb348432580fe7
Autor:
Jamie E Meegan, Ciara M Shaver, Nathan D Putz, Jordan J Jesse, Stuart R Landstreet, Han Noo Ri Lee, Tatiana N Sidorova, J Brennan McNeil, James L Wynn, Joyce Cheung-Flynn, Padmini Komalavilas, Colleen M Brophy, Lorraine B Ware, Julie A Bastarache
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228727 (2020)
Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported tha
Externí odkaz:
https://doaj.org/article/e068d1cb04d84396b01306e30f41f480
Autor:
Sarah J Atkinson, Brian M Varisco, Mary Sandquist, Meghan N Daly, Lindsey Klingbeil, Joshua W Kuethe, Emily F Midura, Kelli Harmon, Amy Opoka, Patrick Lahni, Giovanna Piraino, Paul Hake, Basilia Zingarelli, Joel E Mortensen, James L Wynn, Hector R Wong
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 455-463 (2016)
Abstract Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age
Externí odkaz:
https://doaj.org/article/bb6ee77a25884b63ba7c9179b3e415c4
Autor:
Melania M. Bembea, Michael Agus, Ayse Akcan-Arikan, Peta Alexander, Rajit Basu, Tellen D. Bennett, Desmond Bohn, Leonardo R. Brandão, Ann-Marie Brown, Joseph A. Carcillo, Paul Checchia, Jill Cholette, Ira M. Cheifetz, Timothy Cornell, Allan Doctor, Michelle Eckerle, Simon Erickson, Reid W.D. Farris, E. Vincent S. Faustino, Julie C. Fitzgerald, Dana Y. Fuhrman, John S. Giuliano, Kristin Guilliams, Michael Gaies, Stephen M. Gorga, Mark Hall, Sheila J. Hanson, Mary Hartman, Amanda B. Hassinger, Sharon Y. Irving, Howard Jeffries, Philippe Jouvet, Sujatha Kannan, Oliver Karam, Robinder G. Khemani, Niranjan Kissoon, Jacques Lacroix, Peter Laussen, Francis Leclerc, Jan Hau Lee, Stephane Leteurtre, Katie Lobner, Patrick J. McKiernan, Kusum Menon, Paul Monagle, Jennifer A. Muszynski, Folafoluwa Odetola, Robert Parker, Nazima Pathan, Richard W. Pierce, Jose Pineda, Jose M. Prince, Karen A. Robinson, Courtney M. Rowan, Lindsay M. Ryerson, L. Nelson Sanchez-Pinto, Luregn J. Schlapbach, David T. Selewski, Lara S. Shekerdemian, Dennis Simon, Lincoln S. Smith, James E. Squires, Robert H. Squires, Scott M. Sutherland, Yves Ouellette, Michael C. Spaeder, Vijay Srinivasan, Marie E. Steiner, Robert C. Tasker, Ravi Thiagarajan, Neal Thomas, Pierre Tissieres, Chani Traube, Marisa Tucci, Katri V. Typpo, Mark S. Wainwright, Shan L. Ward, R. Scott Watson, Scott Weiss, Jane Whitney, Doug Willson, James L. Wynn, Nadir Yeyha, Jerry J. Zimmerman
Publikováno v:
Pediatrics
Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f8da307efc2410e3bc23f4eec206fc
https://doi.org/10.1542/peds.2021-052888b
https://doi.org/10.1542/peds.2021-052888b
Autor:
Angela N. Lewis, Diomel de la Cruz, James L. Wynn, Lauren C. Frazer, William Yakah, Camilia R. Martin, Heeju Yang, Elena Itriago, Jana Unger, Amy B. Hair, Jessica Miele, Brynne A. Sullivan, Ameena Husain, Misty Good
Publikováno v:
Neonatology
Introduction: The neonatal sequential organ failure assessment (nSOFA) score is a tool for calculating mortality risk of infants in the neonatal intensive care unit. The utility of the nSOFA in determining the risk of mortality or the association wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a44908b43b85322f63847fe519adaa4
https://doi.org/10.1159/000522560
https://doi.org/10.1159/000522560
Autor:
Joseph M. Bliss, James L. Wynn
Publikováno v:
Frontiers in Pediatrics, Vol 5 (2017)
Externí odkaz:
https://doaj.org/article/b2d7dcabc02e434ab32187be7565ef0e
Autor:
Kusum, Menon, Luregn J, Schlapbach, Samuel, Akech, Andrew, Argent, Paolo, Biban, Enitan D, Carrol, Kathleen, Chiotos, Mohammod, Jobayer Chisti, Idris V R, Evans, David P, Inwald, Paul, Ishimine, Niranjan, Kissoon, Rakesh, Lodha, Simon, Nadel, Cláudio Flauzino, Oliveira, Mark, Peters, Benham, Sadeghirad, Halden F, Scott, Daniela C, de Souza, Pierre, Tissieres, R Scott, Watson, Matthew O, Wiens, James L, Wynn, Jerry J, Zimmerman, Lauren R, Sorce
Publikováno v:
Critical Care Medicine
Supplemental Digital Content is available in the text.
Objective: To determine the associations of demographic, clinical, laboratory, organ dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic shock in chil
Objective: To determine the associations of demographic, clinical, laboratory, organ dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic shock in chil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d11caaa64df491454a3ca5ff25164bd
http://europepmc.org/articles/PMC8670345
http://europepmc.org/articles/PMC8670345
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Essentially, all neonates are exposed to infections, antibiotics, or vaccines early in their lives. This is especially true for those neonates born underweight or premature. In contrast to septic adults and children who are at an increased risk for s
Externí odkaz:
https://doaj.org/article/a1a6d5c46c714a619c8fedd721edbf41