Zobrazeno 1 - 10
of 22
pro vyhledávání: '"James L, Searcy"'
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89970 (2014)
The structural integrity of cerebral vessels is compromised during ageing. Abnormal amyloid (Aβ) deposition in the vasculature can accelerate age-related pathologies. The cerebrovascular response associated with ageing and microvascular Aβ depositi
Externí odkaz:
https://doaj.org/article/75e6be1822804e9a9323059825a4fad2
Autor:
Heather M Buechel, Jelena Popovic, James L Searcy, Nada M Porter, Olivier Thibault, Eric M Blalock
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18387 (2011)
Age-related cognitive deficits negatively affect quality of life and can presage serious neurodegenerative disorders. Despite sleep disruption's well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies ha
Externí odkaz:
https://doaj.org/article/cca6ecae816242c5837ed1b44adcef45
Autor:
Caitlin S Latimer, James L Searcy, Michael T Bridges, Lawrence D Brewer, Jelena Popović, Eric M Blalock, Philip W Landfield, Olivier Thibault, Nada M Porter
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26812 (2011)
Healthy brain aging and cognitive function are promoted by exercise. The benefits of exercise are attributed to several mechanisms, many which highlight its neuroprotective role via actions that enhance neurogenesis, neuronal morphology and/or neurot
Externí odkaz:
https://doaj.org/article/b50ce6239c58484c9293c5b3e7a93b83
Autor:
Eric M Blalock, Jeremiah T Phelps, Tristano Pancani, James L Searcy, Katie L Anderson, John C Gant, Jelena Popovic, Margarita G Avdiushko, Don A Cohen, Kuey-Chu Chen, Nada M Porter, Olivier Thibault
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10405 (2010)
Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Al
Externí odkaz:
https://doaj.org/article/a5c9cec00f114fa6a8cdca7e9c312083
Autor:
Jessica Duncombe, Margaret Binnie, Yasmina Manso, Juraj Koudelka, James L. Searcy, Ross J. Lennen, Raj N. Kalaria, Karen Horsburgh, Masafumi Ihara, Maurits A. Jansen, Scott P. Webster, Akihiro Kitamura, Ian Marshall
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Kitamura, A, Manso Sanz, Y, Duncombe, J, Searcy, J, Koudelka, J, Binnie, M, Webster, S, Lennen, R J, Jansen, M, Ihara, M, Kalaria, R N & Horsburgh, K 2017, ' Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion ', Scientific Reports . https://doi.org/10.1038/s41598-017-04082-0
Scientific Reports
Kitamura, A, Manso Sanz, Y, Duncombe, J, Searcy, J, Koudelka, J, Binnie, M, Webster, S, Lennen, R J, Jansen, M, Ihara, M, Kalaria, R N & Horsburgh, K 2017, ' Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion ', Scientific Reports . https://doi.org/10.1038/s41598-017-04082-0
Scientific Reports
Chronic cerebral hypoperfusion is a major cause of age-related vascular cognitive impairment. A well-characterised mouse model has shown that hypoperfusion results in gliovascular and white matter damage and impaired spatial working memory. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46eeb3e4f0d99e73f12bff21f48b12c
https://doaj.org/article/a99c822285fe43d893ff1f0c5c5d7bd5
https://doaj.org/article/a99c822285fe43d893ff1f0c5c5d7bd5
Autor:
Philip R. Holland, Natalia Salvadores, Rajesh N. Kalaria, Colin Smith, Emma R. Wood, Greig Lawson, Fiona Scott, Guiquan Chen, Gillian Scullion, James L. Searcy, Mark E. Bastin, Joanna M. Wardlaw, Karen Horsburgh, Masafumi Ihara
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 35:1005-1014
Cerebral small vessel disease (SVD) is a major cause of age-related cognitive impairment and dementia. The pathophysiology of SVD is not well understood and is hampered by a limited range of relevant animal models. Here, we describe gliovascular alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c043991e47aa05b147c5f71a17a822a
https://doi.org/10.1038/jcbfm.2015.12
https://doi.org/10.1038/jcbfm.2015.12
Publikováno v:
Salvadores, N, Searcy, J L, Holland, P R & Horsburgh, K 2017, ' Chronic cerebral hypoperfusion alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and hemorrhages in Tg-SwDI mice ', Clinical science . https://doi.org/10.1042/CS20170962
Cerebral hypoperfusion is an early feature of Alzheimer’s disease (AD) that influences the progression from mild cognitive impairment to dementia. Understanding the mechanism is of critical importance in the search for new effective therapies. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c46911d70d96a9768b5d36ff857c09
https://pubmed.ncbi.nlm.nih.gov/28667120
https://pubmed.ncbi.nlm.nih.gov/28667120
Autor:
Yasmina, Manso, Philip R, Holland, Akihiro, Kitamura, Stefan, Szymkowiak, Jessica, Duncombe, Edel, Hennessy, James L, Searcy, Martina, Marangoni, Andrew D, Randall, Jon T, Brown, Barry W, McColl, Karen, Horsburgh
Publikováno v:
Glia. 66(1)
Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant to studying cerebral vascular disease, we have previously shown that cerebral hypoperfusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a98946679126391026822fdcbc43639e
https://pubmed.ncbi.nlm.nih.gov/28722234
https://pubmed.ncbi.nlm.nih.gov/28722234
Autor:
Tristano Pancani, Inga Kadish, Kuey-Chu Chen, Nada M. Porter, Jelena Popovic, Eric M. Blalock, James L. Searcy, Michael Paul Murphy, Katie L. Anderson, Philip W. Landfield, Olivier Thibault, Tina L. Beckett, Jeremiah T. Phelps
Publikováno v:
Journal of Alzheimer's Disease. 30:943-961
Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type (PPAR-γ) receptors and are used clinically for the treatment of type 2 diabetes where they have been shown to reestablish insulin sensitivity, improve lipid profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d368576f8447819fa800fbb13a5ed879
https://doi.org/10.3233/jad-2012-111661
https://doi.org/10.3233/jad-2012-111661
Autor:
Sarah F. Martin, James L. Searcy, Catherine M. Gliddon, Ruth F. Deighton, Thierry Le Bihan, Lorraine E. Kerr, Rachel James, Joanne Povey, James McCulloch, Karen Horsburgh
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
James, R, Searcy, J L, Le Bihan, T, Martin, S F, Gliddon, C M, Povey, J, Deighton, R F, Kerr, L E, McCulloch, J & Horsburgh, K 2012, ' Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge ', Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 1, pp. 164-176 . https://doi.org/10.1038/jcbfm.2011.120
James, R, Searcy, J L, Le Bihan, T, Martin, S F, Gliddon, C M, Povey, J, Deighton, R F, Kerr, L E, McCulloch, J & Horsburgh, K 2012, ' Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge ', Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 1, pp. 164-176 . https://doi.org/10.1038/jcbfm.2011.120
Apolipoprotein E (APOE)-ɛ4 is associated with a deleterious outcome after ischemic brain injury, which may involve abnormal regulation of mitochondrial function. We have assessed the mitochondrial proteomic response of APOE-ɛ3 and APOE-ɛ4 transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f1f91da90dbecc16eb9bbe8186df6b
http://europepmc.org/articles/PMC3323298
http://europepmc.org/articles/PMC3323298