Zobrazeno 1 - 10
of 60
pro vyhledávání: '"James L, Krahenbuhl"'
Autor:
Grace L Davis, Nashone A Ray, Ramanuj Lahiri, Thomas P Gillis, James L Krahenbuhl, Diana L Williams, Linda B Adams
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 8, p e2404 (2013)
BACKGROUND: The inability of Mycobacterium leprae to grow on axenic media has necessitated specialized techniques in order to determine viability of this organism. The purpose of this study was to develop a simple and sensitive molecular assay for de
Externí odkaz:
https://doaj.org/article/dec6ab604c7140589703845b08d5f51c
Autor:
Richard W Truman, P Kyle Andrews, Naoko Y Robbins, Linda B Adams, James L Krahenbuhl, Thomas P Gillis
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 2, Iss 11, p e328 (2008)
Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We have developed a real-time PCR assay for quantifying M. le
Externí odkaz:
https://doaj.org/article/f1cc2f836a1345799857046897eba22c
Autor:
James L., Krahenbuhl
Publikováno v:
Hansenologia Internationalis, Vol 23, Iss Especial (1998)
Externí odkaz:
https://doaj.org/article/20e629b629b244da8141329f67c76961
Publikováno v:
The Journal of Infectious Diseases. 201:1736-1742
The role played by apoptosis in host response to Mycobacterium leprae is unclear. Here, we studied in vitro induction of apoptosis in mouse bone marrow-derived macrophages infected with live and irradiated M. leprae, as a function of multiplicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257b587544fa6e52ef8491484d78b2d3
https://doi.org/10.1086/652499
https://doi.org/10.1086/652499
Autor:
James L. Krahenbuhl, Ramanuj Lahiri
Publikováno v:
Leprosy Review. 79:401-409
Objectives Leprosy transmission remains poorly understood, though, prolonged skin contact and/or infection via nasal mucosa, are considered likely. Problematic in any transmission hypothesis is the fastidious nature of Mycobacterium leprae outside it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7c119e3dea3b67a9209f677d205e18
https://doi.org/10.47276/lr.79.4.401
https://doi.org/10.47276/lr.79.4.401
Publikováno v:
Leprosy Review. 79:311-314
Summary Objective The immune-mediated events that precipitate erythema nodosum leprosum (ENL) are not well understood. One component may be the complexing of antibody with antigens released from infected macrophages, the activation of complement and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0acfae3b5840205d2af2f1506930ba7
https://doi.org/10.47276/lr.79.3.311
https://doi.org/10.47276/lr.79.3.311
Autor:
Kazue Narahashi, Paula F. B. Rebello, Mariane Martins de Araújo Stefani, Ana Lúcia O.M. Sousa, Gisner A. S. Pereira, James L. Krahenbuhl, Maurício Barcelos Costa, Maria Kátia Gomes, Thomas P. Gillis, Celina Maria Turchi Martelli
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 77:829-833
Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities. Single skin lesion paucibacillary leprosy volunteers (N = 135) recruited in three Brazilian ende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa189eda0b95b27eb06664b160765c7c
https://doi.org/10.4269/ajtmh.2007.77.829
https://doi.org/10.4269/ajtmh.2007.77.829
Autor:
Cynthia S. Dowd, Clifton E. Barry, Ujjini H. Manjunatha, James L. Krahenbuhl, Ramanuj Lahiri, Baljit Randhawa
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:3350-3354
Leprosy responds very slowly to the current multidrug therapy, and hence there is a need for novel drugs with potent bactericidal activity. PA-824 is a 4-nitroimidazo-oxazine that is currently undergoing phase I clinical trials for the treatment of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e7500a0917b390e21a802d96a9b4fb
https://doi.org/10.1128/aac.00488-06
https://doi.org/10.1128/aac.00488-06
Publikováno v:
Journal of Medical Microbiology. 54:235-242
Mycobacterium lepraecannot be cultured, so ascertaining viability of the organism remains a major obstacle, impeding many avenues of investigation. This study tested a two-colour, Syto9 and propidium iodide, fluorescence assay, which scores for membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3025690670c9bc61d6c99efc34e4d46d
https://doi.org/10.1099/jmm.0.45700-0
https://doi.org/10.1099/jmm.0.45700-0
Autor:
James L. Krahenbuhl
Publikováno v:
Leprosy Review. 87:267-268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6aa9fa97319e6f51a65a80397440f7
https://doi.org/10.47276/lr.87.2.267
https://doi.org/10.47276/lr.87.2.267