Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James Kobie"'
Autor:
Natalie M. Leblanc, Kamila Alexander, Sierra Carter, Hugh Crean, Ladrea Ingram, James Kobie, James McMahon
Publikováno v:
Women's Health Reports, Vol 1, Iss 1, Pp 132-142 (2020)
Background: Threats to sexual health can emerge across one's life span and are influenced by individual and interpersonal experiences, as well as certain environmental exposures. Although previous research has recognized the importance of ecological
Externí odkaz:
https://doaj.org/article/1c240fc1e1404a8797dbd354641e568e
Autor:
James Kobie, Jun-Gyu Park, Sanghita Sarkar, Madhubanti Basu, Andreas Loos, Jennifer Woo, Chengjin Ye, Vu Truong, Richard Bowen, Mark R Walter, Luis Martinez-Sobrido, Michael Piepenbrink
Publikováno v:
The Journal of Immunology. 208:65.11-65.11
To determine if pan-coronavirus neutralizing antibodies are induced by SARS-CoV-2 infection, human monoclonal antibodies (mAb) targeting the highly conserved S2 domain of the Spike glycoprotein were cloned from B cells isolated from convalescent pati
Autor:
James Kobie, Michael Piepenbrink, Christopher Fucile, Catherine Bunce, Li-Xing Man, Jane Liesveld, Alexander F. Rosenberg, Michael Keefer, Madhubanti Basu
Publikováno v:
The Journal of Immunology. 208:168.13-168.13
The most potent and broad HIV envelope (Env)-specific antibodies often when reverted to their inferred germline versions representing the naïve B cell receptor, fail to bind Env suggesting that the initial responding B cell population is not exclusi
Autor:
James Kobie, Philip Barnette, Shilpi Pandey, David Spencer, Madhubanti Basu, Michael Piepenbrink, Michael Keefer, Ann J Hessell, Nancy L Haigwood, Sanghita Sarkar
Publikováno v:
The Journal of Immunology. 204:247.11-247.11
Induction of a sustained and broad neutralizing antibody (Ab) response is a major goal in developing a protective HIV vaccine. Many HIV Envelope (Env)-specific broadly neutralizing antibodies isolated to date exhibit substantial somatic hypermutation
Autor:
James Kobie, Michael Piepenbrink, Christopher Fucile, Alexander F. Rosenberg, Madhubanti Basu
Publikováno v:
The Journal of Immunology. 204:247.16-247.16
The most potent and broad HIV envelope (Env)-specific antibodies (Abs) often when reverted to their inferred germline versions representing the naïve B cell receptor, usually fail to bind Env. This may suggest that the primary B cell population that
Autor:
David A Spencer, Delphine C Malherbe, Heidi Henderson, Shilpi Pandy, Néstor Vázquez Bernat, Monika Àdori, Ben Goldberg, Nicholas Dambrauskas, William Sutton, Noah Sather, James Kobie, Margaret E Ackerman, Gunilla B Karlsson Hedestam, Nancy Logan Haigwood, Ann Jones Hessell
Publikováno v:
The Journal of Immunology. 202:72.9-72.9
Eliciting Abs that efficiently neutralize multi-clade HIV strains will likely be necessary for an effective HIV-1 vaccine. Such broadly neutralizing Abs have been cloned from a minority of chronically infected patients but have yet to be generated th
Publikováno v:
The Journal of Immunology. 200:60.17-60.17
Influenza’s propensity for antigenic drift and shift, and to elicit predominantly strain specific antibodies (Abs) leaves humanity susceptible to waves of new strains with pandemic potential for which limited or no immunity may exist. Subsequently
Autor:
James Kobie, Madhubanti Basu, Michael Piepenbrink, Czestochowa Francois, Fritzlaine Roche, Christopher Fucile, Alexander Rosenberg, Jane Liesveld, Michael Keefer
Publikováno v:
The Journal of Immunology. 200:125.24-125.24
Induction of long-lived plasma cells producing protective HIV-1 Envelope (Env)-specific antibody (Ab) is a primary goal of HIV vaccine strategies. However, vaccine-induced Env-specific human plasma cells have not yet been identified. In an effort to
Publikováno v:
The Journal of Immunology. 198:81.1-81.1
Analysis of lymphocytes in bulk masks the heterogeneity of cellular processes. Through advancements in single cell technologies finer resolution and the true complexities of cell populations can be revealed. A major limitation of single cell technolo
Autor:
James Kobie, Sanghita Sarkar, Michael Piepenbrink, Madhubanti Basu, Michael Keefer, Juilee Thakar, Ann Jones Hessell, Nancy Logan Haigwood
Publikováno v:
The Journal of Immunology. 198:225.16-225.16
Induction of a sustained and broad antibody (Ab) response is a major goal in developing a protective HIV vaccine. DNA is an attractive priming strategy when combined with protein or viral vector boosting; however, DNA priming alone fails to induce a