Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James Kevin Y Tan"'
Autor:
David J. Peeler, Yilong Cheng, James Kevin Y Tan, Drew L. Sellers, Suzie H. Pun, Philip J. Horner
Publikováno v:
Biomaterials. 127:89-96
Cationic polymer gene delivery vehicles that effectively resist premature serum degradation often have difficulty releasing their nucleic acid cargoes. In this work, we report a pH-sensitive polymer (SP), poly(oligo(ethylene glycol) monomethyl ether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df17123f8be8eaae1bac4a333424aabd
https://doi.org/10.1016/j.biomaterials.2017.02.036
https://doi.org/10.1016/j.biomaterials.2017.02.036
Autor:
Suzie H. Pun, Stephen J. Salipante, David J. Peeler, James Kevin Y Tan, Drew L. Sellers, Julio Marco B. Pineda, Brynn R Olden, Veronica L. Porubsky
Publikováno v:
ACS Nano
While biologic drugs such as proteins, peptides, or nucleic acids have shown promise in the treatment of neurodegenerative diseases, the blood-brain barrier (BBB) severely limits drug delivery to the central nervous system (CNS) after systemic admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1ae88e0bc02be159f5edeb97d71c4a
https://europepmc.org/articles/PMC7651855/
https://europepmc.org/articles/PMC7651855/
Autor:
David J. Peeler, James Kevin Y Tan, Don O. Maris, Drew L. Sellers, Philip J. Horner, Hua Wei, Suzie H. Pun, Yilong Cheng
Publikováno v:
Small. 12:2750-2758
The architecture of polycations plays an important role in both gene transfection efficiency and cytotoxicity. In this work, a new polymer, sunflower poly(2-dimethyl amino)ethyl methacrylate) (pDMAEMA) were prepared by atom transfer radical polymeriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922b041d0a6688f3f9569b862bf127d5
https://doi.org/10.1002/smll.201502930
https://doi.org/10.1002/smll.201502930
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Frontiers in Molecular Neuroscience, Vol 9 (2016)
With an increased prevalence and understanding of central nervous system injuries and neurological disorders, nucleic acid therapies are gaining promise as a way to regenerate lost neurons or halt disease progression. While more viral vectors have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f681c04151aeb0523c6508ed4c800f43
https://pubmed.ncbi.nlm.nih.gov/27847462
https://pubmed.ncbi.nlm.nih.gov/27847462
Autor:
Thomas J. Matula, Hua Wei, Suzie H. Pun, James Kevin Y Tan, Binhan Pham, Pierre D. Mourad, Philip J. Horner, Don O. Maris, Drew L. Sellers, Yujin Zong, Ashton S. Hemphill, Carol H. Miao, Camilo Perez
Neurons in the brain can be damaged or lost from neurodegenerative disease, stroke, or traumatic injury. Although neurogenesis occurs in mammalian adult brains, the levels of natural neurogenesis are insufficient to restore function in these cases. G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311f553d4bb1facce29dbefb2abea6d9
https://europepmc.org/articles/PMC4944389/
https://europepmc.org/articles/PMC4944389/
Autor:
Joan G. Schellinger, James Kevin Y Tan
Publikováno v:
Therapeutic delivery. 6(10)
With the advances in material design and synthesis, more complex delivery systems with active targeting and multiple functionalities are being developed for a wide variety of applications. New chemistries that utilize thiols, amines, and carboxylic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706bd98191426e856b0678cbb7a2b778
https://pubmed.ncbi.nlm.nih.gov/26448552
https://pubmed.ncbi.nlm.nih.gov/26448552
Autor:
Hua Wei, James Kevin Y Tan, Suzie H. Pun, Drew L. Sellers, Philip J. Horner, Jennifer L. Choi
Publikováno v:
Biomaterials. 54
There is currently no cure for neuron loss in the brain, which can occur due to traumatic injury or neurodegenerative disease. One method proposed to enhance neurogenesis in the brain is gene transfer to neural progenitor cells. In this work, a guani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117795b735a76ed1b0cd5facce3abe88
https://pubmed.ncbi.nlm.nih.gov/25907042
https://pubmed.ncbi.nlm.nih.gov/25907042
Publikováno v:
ChemInform. 44
The development of nanoscale drug delivery vehicles is an exciting field due to the ability of these vehicles to improve the pharmacokinetic and pharmacodynamic properties of existing therapeutics. These vehicles can improve drug effectiveness and sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ac50f029352445deef8a2e12bdd0ff6
https://doi.org/10.1002/chin.201305174
https://doi.org/10.1002/chin.201305174
Publikováno v:
Topics in current chemistry. 310
The development of nanoscale drug delivery vehicles is an exciting field due to the ability of these vehicles to improve the pharmacokinetic and pharmacodynamic properties of existing therapeutics. These vehicles can improve drug effectiveness and sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4a4769faba39194cc830577b2f112f7
https://pubmed.ncbi.nlm.nih.gov/21809189
https://pubmed.ncbi.nlm.nih.gov/21809189
Publikováno v:
Topics in Current Chemistry ISBN: 9783642271380
The development of nanoscale drug delivery vehicles is an exciting field due to the ability of these vehicles to improve the pharmacokinetic and pharmacodynamic properties of existing therapeutics. These vehicles can improve drug effectiveness and sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3df86934b0c2a8ae6be500112a701ba9
https://doi.org/10.1007/128_2011_209
https://doi.org/10.1007/128_2011_209