Zobrazeno 1 - 10
of 49
pro vyhledávání: '"James Kempson"'
Autor:
Manivel Pitchai, Antonio Ramirez, Don M. Mayder, Sankar Ulaganathan, Hemantha Kumar, Darpandeep Aulakh, Anuradha Gupta, Arvind Mathur, James Kempson, Nicholas Meanwell, Zachary M. Hudson, Martins S. Oderinde
Publikováno v:
ACS Catalysis. 13:647-658
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf3537959171d5dfd1403980e9ceb98
https://doi.org/10.1021/acscatal.2c05554
https://doi.org/10.1021/acscatal.2c05554
Autor:
Martins S. Oderinde, Soomin Jin, Jayanta Das, Christine Jorge, Shiuhang Yip, Antonio Ramirez, Dauh-Rurng Wu, Ying Li, James Kempson, Nicholas A. Meanwell, Arvind Mathur, T. G. Murali Dhar
Publikováno v:
ACS Catalysis. 12:12511-12520
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a85d4bd93999c6f644ca73426df7b4
https://doi.org/10.1021/acscatal.2c04213
https://doi.org/10.1021/acscatal.2c04213
Autor:
James Kempson, Xiaoping Hou, Jung-Hui Sun, Michael Wong, Joseph Pawluczyk, Jianqing Li, Subramaniam Krishnananthan, Eric M. Simmons, Yi Hsiao, Yi-Xin Li, Dawn Sun, Dauh-Rurng Wu, Wei Meng, Saleem Ahmad, Lidet Negash, Robert Brigance, Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Pratik Devasthale, Jeffrey A. Robl, Arvind Mathur
Publikováno v:
Organic Process Research & Development. 26:1327-1335
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35fda97669790a07bfdfb80a55523b6b
https://doi.org/10.1021/acs.oprd.2c00036
https://doi.org/10.1021/acs.oprd.2c00036
Autor:
Jianqing Li, Daniel Smith, Joseph Pawluczyk, Subramaniam Krishnananthan, Bei Wang, Xiaoping Hou, Rulin Zhao, James Kempson, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Nageswararao Maddala, Muthalagu Vetrichelvan, Anuradha Gupta, John E. Macor, Carolyn D. Dzierba, Arvind Mathur
Publikováno v:
Organic Process Research & Development. 26:437-446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a19c3388a6191ae5b39884a54b5753bd
https://doi.org/10.1021/acs.oprd.1c00452
https://doi.org/10.1021/acs.oprd.1c00452
Autor:
Rulin Zhao, Zhenqiu Hong, Bei Wang, James Kempson, Lyndon Cornelius, Jianqing Li, Yi-Xin Li, Arvind Mathur
Publikováno v:
Organic & Biomolecular Chemistry. 20:9746-9752
A simple and expeditious method for the regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates 2 was developed with excellent regioselectivity and good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9488bab1a648f5ba78a15cac646e81a3
https://doi.org/10.1039/d2ob02006h
https://doi.org/10.1039/d2ob02006h
Autor:
Shiuhang Yip, Emily Luk, Anwar Murtaza, Yong Zhang, Michael A. Poss, Louis J. Lombardo, Nimmi Raghavan, Zheng Yang, James Kempson, Audris Huang, David R. Tortolani, Jesse Swanson, Xiaoping Hou, Joseph Pawluczyk, James Smalley, Honghe Wan, Karen E. Parrish, Robert M. Borzilleri, Ashok V. Purandare, Karen Augustine-Rauch, Andrew F. Donnell
Publikováno v:
Journal of Medicinal Chemistry. 64:15787-15798
Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models. However, on-target adverse cardiovascular effects have limited the clinical use of TGFβ rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebde71751ab18259045cb79ccd54677
https://doi.org/10.1021/acs.jmedchem.0c02043
https://doi.org/10.1021/acs.jmedchem.0c02043
Autor:
Shu Chang, Anthony V. Azzara, Yi-Xin Li, Marta Dabros, James Kempson, Reshma Panemangelor, Huji Turdi, Kimberly A. Foster, William J. Keim, Jean M. Whaley, Jeffrey A. Robl, Fang Moore, Luping Chen, Mary Jane Cullen, Xiaoping Hou, Atsu Apedo, R. Michael Lawrence, Arvind Mathur, David G. Harden, Wei Meng, Kevin O'Malley, Mary Ann Pelleymounter, Hannguang Chao, Pratik Devasthale, Jon J. Hangeland, Zhengping Ma, Dauh-Rurng Wu, Robert Paul Brigance, Guohua Zhao, Lynn M. Abell, Qi Gao, Susan Harvey, Lisa M. Kopcho, Dong Cheng, Elizabeth A. Dierks, Ching-Hsuen Chu, Suzanne Rooney, Xiang-Yang Ye, Saleem Ahmad, Wei Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14773-14792
MGAT2 inhibition is a potential therapeutic approach for the treatment of metabolic disorders. High-throughput screening of the BMS internal compound collection identified the aryl dihydropyridinone compound 1 (hMGAT2 IC50 = 175 nM) as a hit. Compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90999a2854f1a395c0459b5cd876d
https://doi.org/10.1021/acs.jmedchem.1c01356
https://doi.org/10.1021/acs.jmedchem.1c01356
Autor:
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J. Swidorski, Zheng Liu, Brian L. Venables, Ny Sin, Richard A. Hartz, Tricia Protack, Zeyu Lin, Sharon Zhang, Zhufang Li, Dauh-Rurng Wu, Peng Li, James Kempson, Xiaoping Hou, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Hyunsoo Park, Amy Sarjeant, Yulia Benitex, Sandhya Rahematpura, Dawn Parker, Thomas Phillips, Roy Haskell, Susan Jenkins, Kenneth S. Santone, Mark Cockett, Umesh Hanumegowda, Ira Dicker, Nicholas A. Meanwell, Mark Krystal
Publikováno v:
Journal of medicinal chemistry. 65(18)
GSK3640254 is an HIV-1 maturation inhibitor (MI) that exhibits significantly improved antiviral activity toward a range of clinically relevant polymorphic variants with reduced sensitivity toward the second-generation MI GSK3532795 (BMS-955176). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd326815d3682de3b91571d910517928
https://pubmed.ncbi.nlm.nih.gov/36044257
https://pubmed.ncbi.nlm.nih.gov/36044257
Autor:
Liping Zhang, James Kempson, Anuradha Gupta, Pirama Nayagam Arunachalam, Yoganand Shanmugam, Suresh Krishnamoorthy, Prakasam Kuppusamy, Zhenqiu Hong, Cherney Emily Charlotte, Richard R. Rampulla, Roshan Y. Nimje, Duraisamy Ramasamy, Aaron Balog, Robert M. Borzilleri, Arvind Mathur, Haridhas Manoharan
Publikováno v:
Organic Process Research & Development. 25:1680-1689
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7b59382a9f923a409405a406bda275
https://doi.org/10.1021/acs.oprd.1c00142
https://doi.org/10.1021/acs.oprd.1c00142
Autor:
Dauh-Rurng Wu, Joseph Pawluczyk, Robert J. Cherney, Joseph A. Tino, Shiuhang Yip, T. G. Murali Dhar, James Kempson, Jianqing Li, Darpandeep Aulakh, Amy A. Sarjeant, Daniel Smith, Arvind Mathur, Cornelius Lyndon A M, Subramaniam Krishnananthan
Publikováno v:
The Journal of Organic Chemistry. 85:10988-10993
We describe an efficient synthetic route to differentially protected diester, 1-(tert-butyl) 4-methyl (1R,2S,4R)-2-methylcyclohexane-1,4-dicarboxylate (+)-1, via palladium-catalyzed methoxycarbonylation of an enol triflate derived from a Hagemann's e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fba5ca413d795699a30093fecc6e060
https://doi.org/10.1021/acs.joc.0c01169
https://doi.org/10.1021/acs.joc.0c01169