Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James Keblesh"'
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25994 (2011)
Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) usually occurs late in the course of HIV-1 infection and the mechanisms underlying HAD pathogenesis are not well understood. Accumulating evidence indicates that neuronal voltage-g
Externí odkaz:
https://doaj.org/article/35966d3830514c66af594c858aaaa72f
Autor:
Jocelyn Jones, Yuri Persidsky, Jianuo Liu, James Haorah, James Keblesh, Allyson Lamb, Adam M. Szlachetka, Saleena Alikunju, Terrence M. Donohue, Catherine Haorei, Travis J. Rump, Huangui Xiong, Matthew C. Zimmerman, P. M. Abdul Muneer
Publikováno v:
Free Radical Biology and Medicine. 49:1494-1504
The studies presented here demonstrate the protective effect of acetyl-L-carnitine (ALC) against alcohol-induced oxidative neuroinflammation, neuronal degeneration, and impaired neurotransmission. Our findings reveal the cellular and biochemical mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35423d579773d1b8a3d9031e7084f78a
https://doi.org/10.1016/j.freeradbiomed.2010.08.011
https://doi.org/10.1016/j.freeradbiomed.2010.08.011
Publikováno v:
Journal of Neuroimmune Pharmacology. 4:317-327
HIV-1-associated neurocognitive disorders (HAND) remains a significant source of morbidity in the era of wide spread use of highly active antiretroviral therapy. Disease is precipitated by low levels of viral growth and glial immune activation within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edd41114990a295b4387c5f93c25d5d
https://doi.org/10.1007/s11481-009-9161-7
https://doi.org/10.1007/s11481-009-9161-7
Publikováno v:
Journal of Neuroimmune Pharmacology. 4:60-70
Human immunodeficiency virus type-1 (HIV-1)-associated dementia (HAD), a severe form of HIV-associated neurocognitive disorders (HAND), describes the cognitive impairments and behavioral disturbances which afflict many HIV-infected individuals. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b6b54802805cea94d596a83f505c16
https://doi.org/10.1007/s11481-008-9106-6
https://doi.org/10.1007/s11481-008-9106-6
Publikováno v:
The European journal of neuroscience. 31(2)
Through their capacity to secrete, upon activation, a variety of bioactive molecules, brain macrophages (and resident microglia) play an important role in brain immune and inflammatory responses. To test our hypothesis that activated macrophages indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de84454c04f4deec2c1952933e6d7e6a
https://pubmed.ncbi.nlm.nih.gov/20074219
https://pubmed.ncbi.nlm.nih.gov/20074219
HIV-1-associated dementia (HAD) describes the cognitive impairments and behavioral disturbances which afflict many HIV-infected individuals. Although the incidence of HAD has decreased significantly in the era of HAART, it remains a significant compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ace13fe9d600d3fffeca3f39b8ac15
https://europepmc.org/articles/PMC2908044/
https://europepmc.org/articles/PMC2908044/
Autor:
James Keblesh, Lin Li, Sung Hwan Yun, Jelena Radulovic, Huangui Xiong, Warren G. Tourtellotte, Barbara L. Trommer
Learning and memory depend upon poorly defined synaptic and intracellular modifications that occur in activated neurons. Mitogen activated protein kinase-extracellular regulated kinase (MAPK-ERK) signaling and de novo protein synthesis are essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f92e829a5a80c9e1456df1dc6f99590
https://europepmc.org/articles/PMC2683345/
https://europepmc.org/articles/PMC2683345/
Publikováno v:
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2(3)
Macrophages play an important role in brain immune and inflammatory responses. They are also critical cells in mediating the pathology of neurodegenerative disorders such as HIV-associated dementia. This is largely through their capacity to secrete a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa80a0965b36c67c7a2174e49186c63
https://pubmed.ncbi.nlm.nih.gov/18040860
https://pubmed.ncbi.nlm.nih.gov/18040860
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64904 (2013)
PLoS ONE
PLoS ONE
Microglia plays a crucial role in the pathogenesis of HIV-1-associated neurocognitive disorders. Increasing evidence indicates the voltage-gated potassium (Kv) channels are involved in the regulation of microglia function, prompting us to hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8985c61f147d2a72af18a1ee9fa62ba4
https://doi.org/10.1371/journal.pone.0064904
https://doi.org/10.1371/journal.pone.0064904