Zobrazeno 1 - 10
of 19
pro vyhledávání: '"James K. Tamura"'
Autor:
Yaqun Zhang, Dianlin Xie, Kevin Kish, Aiying Wang, Stephen P. O'connor, Wei Meng, Herbert E. Klei, Huji Turdi, Lawrence G. Hamann, Robert Zahler, Jovita Marcinkeviciene, Robert Paul Brigance, Thomas Harrity, James K. Tamura, Aberra Fura, Carolyn A. Weigelt, Chao Hannguang J, Mark S. Kirby
Publikováno v:
Journal of Medicinal Chemistry. 53:5620-5628
Continued structure-activity relationship (SAR) exploration within our previously disclosed azolopyrimidine containing dipeptidyl peptidase-4 (DPP4) inhibitors led us to focus on an imidazolopyrimidine series in particular. Further study revealed tha
Autor:
Dong Cheng, Mark R. Witmer, James K. Tamura, Jovita Marcinkeviciene, Gregory A. Locke, Robert F. Carney, Tasir Shamsul Haque, Alan R. Rendina
Publikováno v:
Archives of Biochemistry and Biophysics. 475:72-79
The role of citrate as a physiological modulator of mammalian acetyl-CoA carboxylases (ACCs) has been well studied; however, the mechanism has not been clearly defined. In the current study, we found that citrate activated recombinant human ACC2 by m
Autor:
Gabe Mintier, James K. Tamura, Ching-Hsuen Chu, Dong Cheng, Mark R. Harpel, Gregory A. Locke, Yuli Wu, Joseph W. Cook, John N. Feder, Luping Chen, Yongmi An
Publikováno v:
Protein Expression and Purification. 51:11-21
Acetyl coenzyme A (acetyl-CoA) carboxylase isozyme 1 (ACC1) and acetyl-CoA carboxylase isozyme 2 (ACC2) are critical for de novo fatty acid synthesis and for the regulation of beta-oxidation. Emerging evidence indicates that one or both isozymes migh
Autor:
Jergen Baumann, William A. Schumacher, Thomas E. Steinbacher, Jean H.M. Feyen, Joseph Tamasi, Yizhi Liu, Eileen Bird, James K. Tamura, Anne B. Stewart, Jeffrey S. Bostwick
Publikováno v:
Thrombosis Research. 120:549-558
Introduction TAFI indirectly reduces the action of tPA on plasminogen. Whether exogenous tPA is necessary for TAFI inhibitor efficacy is unclear. Potato carboxypeptidase inhibitor (PCI), a TAFI inhibitor, has shown variable tPA dependence in rat mode
Autor:
Luciano Mueller, Dietmar A. Seiffert, Ruth R. Wexler, Anzhi Wei, John A. Newitt, Jeffrey M. Bozarth, Alexandra H. Nirschl, Paul E. Morin, Xiao Wen, Daniel L. Cheney, James K. Tamura, Alan R. Rendina, William J. Metzler, Nicholas R. Wurtz, E. Scott Priestley
Publikováno v:
Journal of medicinal chemistry. 58(6)
A multidisciplinary, fragment-based screening approach involving protein ensemble docking and biochemical and NMR assays is described. This approach led to the discovery of several structurally diverse, neutral surrogates for cationic factor VIIa P1
Autor:
Steven Grant, Suzanne J. Suchard, Robert P. Rehfuss, Steven G. Nadler, Kathleen M. Gillooly, Anish Suri, Robert Kuhn, Ruth Brosius, Yifan Zhang, Rathna Ravishankar, Kathy A Mink, Aaron P. Yamniuk, Sandra Rex-Rabe, Jenny Xie, Philip Drew, Luisa Salter-Cid, Kimberly S Waggie, James William Bryson, Olga Ignatovich, Lin Cheng, Laura Price, Xiadi Zhou, Yongmi An, James K. Tamura, Virna Borowski, Xiaoxia Yang, Bozena Abramczyk, Vojkan Susulic
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(9)
CD40–CD40L interactions play a critical role in regulating immune responses. Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrated positive clinical effects in patients with autoimmune diseases; however, incidents of thromboembolism
Autor:
Catherine A. Fleener, Dawn K. Stetsko, Patricia M. Davis, James K. Tamura, Steven G. Nadler, Haiqing Wang, James William Bryson, Ruth Brosius, Plummer Christopher, Steven Grant, Theodora W. Salcedo, Olga Ignatovich, Lumelle A. Schneeweis, Suzanne J. Suchard, Selena Kansal, Zheng Yang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 191(9)
Targeting the CD28-CD80/86 pathway with an anti-CD28 antagonist is a promising alternative to current therapies for autoimmunity. However, attempts at generating conventional anti-CD28 mAbs lacking stimulatory activity has been challenging. In this s
Autor:
Aaron P. Yamniuk, Anish Suri, S. Nadler, Danya Liu, Mandy L. Ford, Christian P. Larsen, James K. Tamura, Maylene E. Wagener, David F. Pinelli, Steven Grant
The use of monoclonal antibodies targeting the CD154 molecule remains one of the most effective means of promoting graft tolerance in animal models, but thromboembolic complications during early clinical trials have precluded their use in humans. Fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00903cf65804b5696851c3e302679433
https://europepmc.org/articles/PMC4287239/
https://europepmc.org/articles/PMC4287239/
Autor:
Song Zhao, Adrienne A. Tymiak, James K. Tamura, William Mylott, Rand Jenkins, Mian Gao, Mohammed Jemal, Vendana Hegde, Michael T. Furlong
Publikováno v:
Bioanalysis. 5(11)
Background: There is a need for general and reliable LC–MS assays capable of supporting the bioanalysis of a variety of human monoclonal antibody-based therapeutic drug candidates in animal PK/TK studies. Results: We present herein improvements in
Publikováno v:
Journal of Biological Chemistry. 271:9723-9729
We have previously reported specific labeling of Escherichia coli DNA gyrase by the ATP affinity analog pyridoxal 5'-diphospho-5'adenosine (PLP-AMP), which resulted in inhibition of ATP-dependent reactions. The analog was found to be covalently bound