Zobrazeno 1 - 10
of 34
pro vyhledávání: '"James K. Maurer"'
Autor:
James V. Jester, James K. Maurer
Publikováno v:
Toxicologic Pathology. 27:44-47
In vivo confocal microscopy (CM) provides a unique ability to section optically through living, intact tissues and organs to characterize qualitatively and quantitatively pathological changes in 4 dimensions (x, y, and z, and time). It involves the c
Publikováno v:
Toxicologic Pathology. 26:226-233
We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the tas
Autor:
Ron D. Parker, James K. Maurer
Publikováno v:
Toxicologic Pathology. 24:403-411
Limited information exists on the pathologic changes occurring with surfactant-induced ocular irritation in the context of accidental human exposures and animal tests used to assess for such irritation. The purpose of this study was to begin to chara
Autor:
James V. Jester, H. Dwight Cavanagh, David A. Wilkie, W. Matthew Petroll, Ron D. Parker, James K. Maurer
Publikováno v:
Toxicologic Pathology. 24:412-428
The purpose of this study was to assess the ability of in vivo confocal microscopy (CM) to provide noninvasively derived histopathologic correlates of surfactant-induced eye irritation from which specific pathologic mechanisms can be identified and l
Publikováno v:
Toxicologic Pathology. 22:324-329
Animal models historically used to assess the acute gastric irritation potential of accidental ingestion of consumer products include the dog, pig, rabbit, and cat. In looking at alternative methods that are of shorter duration and more cost-effectiv
Autor:
Stephen I. Rennard, Debra J. Romberger, Kevin E. Driscoll, James K. Maurer, Leslie L. Crosby, Robert C. Lindenschmidt
Publikováno v:
Toxicology and Applied Pharmacology. 106:88-101
A multidisciplinary approach was used to investigate the responses of the respiratory tract to silica (SiO2) or titanium dioxide (TiO2). Rats were intratracheally instilled with 5-100 mg/kg of dust and bronchoalveolar lavage fluid (BALF) lactate dehy
Publikováno v:
Toxicologic Pathology. 18:380-386
1,25-(OH)2 vitamin D3 (D3) and sodium fluoride (NaF) were given to chicken embryos and newly hatched chickens infected with a slow onset strain of avian osteopetrosis-inducing virus [MAV-2(O)] to determine if either agent influenced MAV-2(O)-induced
Autor:
Robert C. Lindenschmidt, Kathleen Ann Belfiore, Kevin E. Driscoll, James K. Maurer, Mary A. Perkins, Janet M. Higgins
Publikováno v:
Toxicology and Applied Pharmacology. 102:268-281
Analysis of bronchoalveolar lavage fluid (BALF) appears to be a sensitive approach to characterizing an acute inflammatory response within the lung. More work, however, is needed to determine if analyses of BALF endpoints can predict chronic response
Autor:
James K. Maurer, Gregory J. Carr
Publikováno v:
Toxicologic Pathology. 26:321-323
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 36(1)
Currently, there are no recognized alternative tests to eliminate the use of animals in ocular irritation testing. A major reason no replacement alternatives have been developed is that the current in vivo data set provides no perspective regarding t