Zobrazeno 1 - 3
of 3
pro vyhledávání: '"James K. Kling"'
Publikováno v:
The Journal of Organic Chemistry. 56:1489-1492
β-(Methanesulfonyl) oxy enones, derived from 1,3-diones, cross-couple with vinylstannanes in 50-80% yields when a substoichiometric amount of Pd(PPh 3 ) 4 and stoichiometric lithium bromide are used. Phenyltributylstannane affords low yields of cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f5e445a7722407e8d7e3a81f4550f9d
https://doi.org/10.1021/jo00004a028
https://doi.org/10.1021/jo00004a028
Autor:
Janice K. Payne, James J. Starling, Hamideh Zarrinmayeh, Stephen D. Mikolajczyk, Kevin L. Law, Timothy Alan Shepherd, Damon L. Meyer, James K. Kling, Louis Nickolaus Jungheim
Publikováno v:
Bioconjugate chemistry. 6(4)
Antibody directed catalysis (ADC), the catalytic conversion of prodrugs to drugs by enzymes localized at disease targets by appropriate monoclonal antibodies, has shown promise in the treatment of cancer in nude mouse xenograft models. We investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d84afe9f793e31dd09d3f2e43647117
https://pubmed.ncbi.nlm.nih.gov/7578364
https://pubmed.ncbi.nlm.nih.gov/7578364
Publikováno v:
HETEROCYCLES. 35:339
Cephalosporin (12) substituted at the C-3' position with the potent oncolytic agent doxorubicin (2) was synthesized as a potential prodrug for the treatment of solid tumors. We envision the conversion of prodrug to free doxorubicin to be mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fe0568c748e183eb3ca76a34781e42
https://doi.org/10.3987/com-92-s22
https://doi.org/10.3987/com-92-s22