Zobrazeno 1 - 10
of 163
pro vyhledávání: '"James K. Coward"'
Publikováno v:
BioTechniques, Vol 35, Iss 5, Pp 926-932 (2003)
Externí odkaz:
https://doaj.org/article/691847ca3dcf4e888bb0e874aef7442c
Publikováno v:
Archives of Biochemistry and Biophysics. 488:140-145
Phosphorus-containing pseudopeptides, racemic at the C-terminal alpha-carbon, are potent mechanism-based inhibitors of folylpolyglutamate synthetase (FPGS). They are mimics of the tetrahedral intermediate postulated to form during FPGS-catalyzed bios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c34404e4138abfcf3b1f0c19cea901
https://doi.org/10.1016/j.abb.2009.06.017
https://doi.org/10.1016/j.abb.2009.06.017
Autor:
James K. Coward, Tara L. Hagena
Publikováno v:
Tetrahedron: Asymmetry. 20:781-794
The synthesis of 6-selenophenyl derivatives of β-1,3 and β-1,4 disaccharides has been explored for the purpose of extending our epoxide fluoridolysis methodology to the synthesis of 5-fluoro analogues of N -acetyl isolactosamine (isoLacNAc, lacto-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0122f73fcd3b21d82009411abfa0b2a
https://doi.org/10.1016/j.tetasy.2009.03.025
https://doi.org/10.1016/j.tetasy.2009.03.025
Publikováno v:
The Journal of Organic Chemistry. 74:617-627
Two epoxide-containing peptidomimetics of the isopeptide, glutamyl-gamma-glutamate, have been synthesized via a route that should be generally applicable to the synthesis of isopeptide analogues in which an oxirane replaces the scissile peptide bond.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7eab055a3e09cda177817b85275b9f
https://doi.org/10.1021/jo801907p
https://doi.org/10.1021/jo801907p
Publikováno v:
FEBS Journal. 275:5408-5421
Glutathionylspermidine is an intermediate formed in the biosynthesis of trypanothione, an essential metabolite in defence against chemical and oxidative stress in the Kinetoplastida. The kinetic mechanism for glutathionylspermidine synthetase (EC 6.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c317901108a97cf508e90d684351387c
https://doi.org/10.1111/j.1742-4658.2008.06670.x
https://doi.org/10.1111/j.1742-4658.2008.06670.x
Autor:
Yonghong Yang, James K. Coward
Publikováno v:
The Journal of Organic Chemistry. 72:5748-5758
The synthesis of suitably protected p-aminophenyl H-phosphinic acids and esters from the corresponding para-substituted aryl halides has been accomplished via the Pd-catalyzed cross-coupling reaction of anilinium hypophosphite, either in the absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0be6e0088ea6ca29dda0ce2598a7e9
https://doi.org/10.1021/jo0707840
https://doi.org/10.1021/jo0707840
Autor:
David M. Bartley, James K. Coward
Publikováno v:
The Journal of Organic Chemistry. 70:6757-6774
Radical addition of H3PO2 to N-/C-protected vinyl glycine led to the corresponding H-phosphinic acid in excellent yield. The non-nucleophilic H-phosphinic acid was converted to a nucleophilic P(III) species, RP(OTMS)2, which was used in two approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472b2e5e9aee3fda7477b46f6df2306d
https://doi.org/10.1021/jo0507439
https://doi.org/10.1021/jo0507439
Autor:
James K. Coward, Anjali R.S. Ganguli
Publikováno v:
Tetrahedron: Asymmetry. 16:411-424
The influence of phenolic acceptor nucleophilicity; for example, 3-substituted, 4-methylumbelliferones, and glycosyl donor electrophilicity; for example, 3- and 4-substituted N -acetylglucosamines, on glycosylation stereochemistry has been evaluated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::310d267d92452466b275204ec8314d3a
https://doi.org/10.1016/j.tetasy.2004.11.053
https://doi.org/10.1016/j.tetasy.2004.11.053
Publikováno v:
BioTechniques. 35:926-932
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce6a4a1a758e426b69c12a2a9688a79
https://doi.org/10.2144/03355bm04
https://doi.org/10.2144/03355bm04
Autor:
Takashi Tsukamoto, Barbara S. Slusher, Juliet M. Flanary, James K. Coward, Nadya Valiaeva, Camilo Rojas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2189-2192
Phosphonate and phosphinate analogues of N -acylated γ-glutamylglutamate were tested for the ability to inhibit glutamate carboxypeptidase II (GCP II). All of the compounds inhibit GCP II with IC 50 values in the low nanomolar range. The comparison
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f839535ea803ee7acbc686a206ba9841
https://doi.org/10.1016/s0960-894x(02)00360-8
https://doi.org/10.1016/s0960-894x(02)00360-8