Výsledky vyhledávání - "James K. Aikins"

Akademický článek

Epigenetic Therapy Augments Classic Chemotherapy in Suppressing the Growth of 3D High-Grade Serous Ovarian Cancer Spheroids over an Extended Period of Time

Autor: Michelle Bilbao, Chelsea Katz, Stephanie L. Kass, Devon Smith, Krystal Hunter, David Warshal, James K. Aikins, Olga Ostrovsky

Publikováno v: Biomolecules, Vol 11, Iss 11, p 1711 (2021)

Recurrent high-grade serous ovarian cancer (HGSC) is clinically very challenging and prematurely shortens patients’ lives. Recurrent ovarian cancer is characterized by high tumor heterogeneity; therefore, it is susceptible to epigenetic therapy in

Externí odkaz: https://doaj.org/article/c185411d397447509a2c8b6b0faa58f5

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Can Cannabidiol Affect the Efficacy of Chemotherapy and Epigenetic Treatments in Cancer?

Autor: James K. Aikins, Olga Ostrovsky, Courtney Griffiths, David Warshal

Publikováno v: Biomolecules
Biomolecules, Vol 11, Iss 766, p 766 (2021)

The success of cannabinoids with chronic neuropathic pain and anxiety has been demonstrated in a multitude of studies. With the high availability of a non-intoxicating compound, cannabidiol (CBD), an over-the-counter medication, has generated heighte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f95e71427b79550f4fc21e8b238f44
https://pubmed.ncbi.nlm.nih.gov/34065479

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Prevalence and risk factors of preoperative anemia in patients undergoing hysterectomy for gynecologic cancer

Autor: Sagar Kamlesh Chokshi, Aliza L. Leiser, James K. Aikins, Cande Ananth

Publikováno v: Journal of Clinical Oncology. 40:e18800-e18800

e18800 Background: Anemia is a common preoperative finding that is associated with increased morbidity and mortality in patients with gynecologic cancers. This study identified the prevalence and risk factors associated with anemia in women undergoin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56ff444ee23e4e37e21ccb3350feea97
https://doi.org/10.1200/jco.2022.40.16_suppl.e18800

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Cannabidiol suppresses 3-dimensional ovarian cancer growth and may enhance potency of classic and epigenetic therapies

Autor: David P. Warshal, Olga Ostrovsky, James K. Aikins, Courtney Griffiths

Publikováno v: Gynecologic Oncology. 162:S102-S103

Objectives: High-grade serous ovarian cancer (HGSOC) is the leading cause of death from gynecological cancer in the US. The majority of patients will present at advanced stage and will recur due to chemoresistance. New therapeutic strategies such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d32cf330503bd059c3799f1c2c83574a
https://doi.org/10.1016/s0090-8258(21)00838-6

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Is routine omentectomy of grossly normal omentum helpful in surgery for ovarian cancer? A look at the tumor microenvironment and its clinical implications

Autor: James K. Aikins, Olga Ostrovsky, Michelle Bilbao

Publikováno v: Gynecologic oncology. 161(1)

Ovarian cancer is uncommon in relation to other women's cancer, however, it is associated with a disproportionate number of deaths due to women's cancer. According to the National Institute of Health, only 1.2% of new cancer diagnoses in the United S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31478e81e4153673a4f4c549e228584
https://pubmed.ncbi.nlm.nih.gov/33436287

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Use of Epigenetic Therapy Shortens Duration of Standard Chemotherapy for Ovarian Cancer with Minimal Toxicity to Normal Tissue

Autor: Olga Ostrovsky, Spencer A. Brown, Leona Chang, Krystal Hunter, James K. Aikins

Publikováno v: Journal of Cancer Science and Clinical Therapeutics.

Objective: (1) Determine if sequential administration of standard chemotherapy (paclitaxel and cisplatin, P/C) with epigenetic drugs effectively targets ovarian cancer and limits toxicity to normal cells. (2) Define whether epigenetic treatment can s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8116767ddee1670ed6310c1c6b18d55d
https://doi.org/10.26502/jcsct.5079056

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