Výsledky vyhledávání - "James K Chipman"

Akademický článek

Optimisation of DNA extraction from the crustacean Daphnia

Autor: Camila Gonçalves Athanasio, James K. Chipman, Mark R. Viant, Leda Mirbahai

Publikováno v: PeerJ, Vol 4, p e2004 (2016)

Daphnia are key model organisms for mechanistic studies of phenotypic plasticity, adaptation and microevolution, which have led to an increasing demand for genomics resources. A key step in any genomics analysis, such as high-throughput sequencing, i

Externí odkaz: https://doaj.org/article/d5ec689de1744095b1f89b85e1fff7cc

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Gene expression and metabolic responses of HepG2/C3A cells exposed to flame retardants and dust extracts at concentrations relevant to indoor environmental exposures

Autor: Mohamed Abou-Elwafa Abdallah, Tim D. Williams, Mark R. Viant, James K. Chipman, Stuart Harrad, Jinkang Zhang

Publikováno v: Chemosphere. 144:1996-2003

Humans are routinely exposed to mixtures of flame retardants (FRs) from multiple sources including indoor dust. As a model to explore the potential effects of FR exposure from indoor dust on human health, the molecular responses of human hepatoma cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd07eb6bfa326e221875bd1c213c7913
https://doi.org/10.1016/j.chemosphere.2015.10.014

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Use of 5-azacytidine in a proof-of-concept study to evaluate the impact of pre-natal and post-natal exposures, as well as within generation persistent DNA methylation changes in Daphnia

Autor: James K. Chipman, Camila Gonçalves Athanásio, Mark R. Viant, Ulf Sommer, Leda Mirbahai

Publikováno v: Ecotoxicology (London, England)

Short-term exposures at critical stages of development can lead to delayed adverse effects long after the initial stressor has been removed, a concept referred to as developmental origin of adult disease. This indicates that organisms’ phenotypes m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa6fed659ad08c64e51cfd2f89ef3f0
https://pubmed.ncbi.nlm.nih.gov/29623456

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Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish

Autor: Alexandra Rolaki, Marlies Halder, Nancy D. Denslow, Dick Roelofs, Raquel N. Carvalho, Ksenia J. Groh, Cheryl A. Murphy, Kristin Schirmer, Karen H. Watanabe, James K. Chipman

Publikováno v: Chemosphere, 120
Chemosphere, 120, 778-792. Elsevier Limited
Groh, K J, Carvalho, R N, Chipman, J K, Denslow, N D, Halder, M, Murphy, C A, Roelofs, D, Rolaki, A, Schirmer, K & Watanabe, K H 2015, ' Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish ', Chemosphere, vol. 120, pp. 778-792 . https://doi.org/10.1016/j.chemosphere.2014.10.006

Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity through levels of biological organization. By determining the linkages between toxicity events at different levels, AOPs lay the foundation for mechanism-based alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adcf07ac00d153925a0cc12dbe0eb2b

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Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 2: Evaluation ofin vitrotopical decontamination efficacy using undamaged skin

Autor: John S. Graham, Charlotte A. Hall, Robert P. Chilcott, Christopher H. Dalton, Helen L. Lydon, James K. Chipman, John Jenner

Publikováno v: Journal of Applied Toxicology. 35:543-550

Previous studies have demonstrated that haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c68f3e5dee44da50bb4610e581bf5dbc
https://doi.org/10.1002/jat.3060

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Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 1: Evaluation ofin vitroclotting efficacy in the presence of certain contaminants

Autor: John S. Graham, Helen L. Lydon, Robert P. Chilcott, James K. Chipman, Christopher H. Dalton, Charlotte A. Hall

Publikováno v: Journal of Applied Toxicology. 35:536-542

The treatment of penetrating, haemorrhaging injuries sustained within a hazardous environment may be complicated by contamination with toxic chemicals. There are currently no specific medical countermeasures for such injuries. Haemostats with an abso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36efd9a8cf5973c98e9ad79f7e111f7b
https://doi.org/10.1002/jat.3019

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Epigenetic memory of environmental organisms: A reflection of lifetime stressor exposures

Autor: Leda Mirbahai, James K. Chipman

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :10-17

Both genetic and epigenetic responses of organisms to environmental factors, including chemical exposures, influence adaptation, susceptibility to toxicity and biodiversity. In model organisms, it is established that epigenetic alterations, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20dd903ac42911644630c66e6cf508b3

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Protein Corona Modulates Uptake and Toxicity of Nanoceria via Clathrin-Mediated Endocytosis

Autor: Emily J. Guggenheim, Robert K. Shaw, Abdullah O. Khan, Hsueh-Shih Chen, Mark R. Viant, James K. Chipman, Joshua Z. Rappoport, Julie Mazzolini, Ralf J. M. Weber

Publikováno v: The Biological bulletin. 231(1)

Particles present in diesel exhaust have been proposed as a significant contributor to the development of acute and chronic lung diseases, including respiratory infection and allergic asthma. Nanoceria (CeO2 nanoparticles) are used to increase fuel e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0757f9e58fdd0fd19bb0fcf3b440af
https://pubmed.ncbi.nlm.nih.gov/27638694

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Furan in heat-treated foods: Formation, exposure, toxicity, and aspects of risk assessment

Autor: Carolin Hamberger, Wolfgang Dekant, Angela Mally, Sabrina Moro, James K. Chipman, Jan-Willem Wegener

Publikováno v: Molecular Nutrition and Food Research, 56, 1197-1211. Wiley-VCH Verlag
Moro, S, Chipman, J K, Wegener, J W M, Hamberger, C, Dekant, W & Mally, A 2012, ' Furan in heat-treated foods: Formation, exposure, toxicity, and aspects of risk assessment ', Molecular Nutrition and Food Research, vol. 56, pp. 1197-1211 . https://doi.org/10.1002/mnfr.201200093

Furan is formed in a variety of heat-treated foods through thermal degradation of natural food constituents. Relatively high levels of furan contamination are found in ground roasted coffee, instant coffee, and processed baby foods. European exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e9f9d8aa8cf1b4db13aa46be0d868c
https://doi.org/10.1002/mnfr.201200093

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