Zobrazeno 1 - 10
of 72
pro vyhledávání: '"James K, Oeser"'
Autor:
Karin J. Bosma, Mohsin Rahim, James K. Oeser, Owen P. McGuinness, Jamey D. Young, Richard M. O'Brien
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101043- (2020)
Objective: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycl
Externí odkaz:
https://doaj.org/article/4701c9a4aec148bc85868d0b7a48679f
Autor:
Kayla A Boortz, Kristen E Syring, Lynley D Pound, Yingda Wang, James K Oeser, Richard M O'Brien
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162439 (2016)
Elevated fasting blood glucose (FBG) has been associated with increased risk for development of type 2 diabetes. Single nucleotide polymorphisms (SNPs) in G6PC2 are the most important common determinants of variations in FBG in humans. Studies using
Externí odkaz:
https://doaj.org/article/4d401ea920754e1d999df831d64728ed
Autor:
James K. Oeser, Owen P. McGuinness, Eric P. Skaar, Christopher A. Lopez, David R. Powell, Slavina B. Goleva, Lea K. Davis, Richard M. O'Brien, Kristen E. Syring, Karin J. Bosma, Kritika Singh
Publikováno v:
J Endocrinol
SLC30A8 encodes the zinc transporter ZnT8. SLC30A8 haploinsufficiency protects against type 2 diabetes (T2D), suggesting that ZnT8 inhibitors may prevent T2D. We show here that, while adult chow fed Slc30a8 haploinsufficient and knockout (KO) mice ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4cba74b458ce7a530559d7de40eaee
https://doi.org/10.1530/joe-20-0138
https://doi.org/10.1530/joe-20-0138
Publikováno v:
The Journal of Biological Chemistry
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) plays a critical role in hepatic glucose production during fasting by mediating the terminal step of the gluconeogenesis and glycogenolysis pathways. In concert with accessory transport proteins, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45301e5d4c36927c685c3789bb80f088
http://europepmc.org/articles/PMC8753184
http://europepmc.org/articles/PMC8753184
Autor:
Mohsin Rahim, Arya Y. Nakhe, Deveena R. Banerjee, Emily M. Overway, Karin J. Bosma, Jonah C. Rosch, James K. Oeser, Bo Wang, Ethan S. Lippmann, David A. Jacobson, Richard M. O'Brien, Jamey D. Young
Publikováno v:
The Journal of biological chemistry. 298(4)
Elevated fasting blood glucose (FBG) is associated with increased risks of developing type 2 diabetes (T2D) and cardiovascular-associated mortality. G6PC2 is predominantly expressed in islets, encodes a glucose-6-phosphatase catalytic subunit that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cefb077412870d3fdfdce04117a4182
https://pubmed.ncbi.nlm.nih.gov/35176280
https://pubmed.ncbi.nlm.nih.gov/35176280
Autor:
Karin J. Bosma, Richard K.P. Benninger, James K. Oeser, Jason D. Lee, Matthew E. Pamenter, Kristen E. Syring, Richard M. O'Brien
Publikováno v:
J Mol Evol
Pancreatic islet zinc levels vary widely between species. Very low islet zinc levels in Guinea pigs were thought to be driven by evolution of the INS gene that resulted in the generation of an isoform lacking a histidine at amino acid 10 in the B cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081bc22a4af71c7cdcb0d38eb1df5374
https://doi.org/10.1007/s00239-019-09898-0
https://doi.org/10.1007/s00239-019-09898-0
Autor:
Owen P. McGuinness, James K. Oeser, Jamey D. Young, Karin J. Bosma, Richard M. O'Brien, Mohsin Rahim
Publikováno v:
Molecular Metabolism, Vol 41, Iss, Pp 101043-(2020)
Molecular Metabolism
Molecular Metabolism
Objective G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee63edf033dbcb3dfd97e0b69febed0f
http://www.sciencedirect.com/science/article/pii/S2212877820301174
http://www.sciencedirect.com/science/article/pii/S2212877820301174
Autor:
Emily M. Overway, Karin J. Bosma, Derek P. Claxton, James K. Oeser, Kritika Singh, Lindsay B. Breidenbach, Hassane S. Mchaourab, Lea K. Davis, Richard M. O'Brien
Publikováno v:
The Journal of Biological Chemistry
G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG). A common single-nucleotide polymorphism (SNP) in G6PC2, rs560887 is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef4340dded8a0d34baa547e94588b64
https://doi.org/10.1016/j.jbc.2021.101534
https://doi.org/10.1016/j.jbc.2021.101534
Autor:
Kayla A. Boortz, Owen P. McGuinness, Lynley D. Pound, Kristen E. Syring, Lisa Bastarache, Joshua C. Denny, James K. Oeser, Richard M. O'Brien, Huan Mo
Publikováno v:
Journal of Molecular Endocrinology. 58:127-139
Genome-wide association study (GWAS) data have linked the G6PC2 gene to variations in fasting blood glucose (FBG). G6PC2 encodes an islet-specific glucose-6-phosphatase catalytic subunit that forms a substrate cycle with the beta cell glucose sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63bca298627582366e32cd24b3306e2
https://doi.org/10.1530/jme-16-0202
https://doi.org/10.1530/jme-16-0202
Autor:
Kristen E. Syring, Kayla A. Boortz, James K. Oeser, David W. Piston, Owen P. McGuinness, Melanie K. Shadoan, Richard M. O'Brien, David R. Powell, Kenneth A. Platt, Alessandro Ustione
Publikováno v:
Endocrinology. 157:4534-4541
Polymorphisms in the SLC30A8 gene, which encodes the ZnT8 zinc transporter, are associated with altered susceptibility to type 2 diabetes (T2D), and SLC30A8 haploinsufficiency is protective against the development of T2D in obese humans. SLC30A8 is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde0820ca2641d0119bb7c5e64311bc3
https://doi.org/10.1210/en.2016-1573
https://doi.org/10.1210/en.2016-1573