Zobrazeno 1 - 2
of 2
pro vyhledávání: '"James Joseph Erdei"'
Autor:
Albert J. Robichaud, Norbert Hoefgen, Karen L. Marquis, Steven M. Grauer, Hans Stange, Radka Graf, Ute Egerland, Thorsten Hage, Christian Grunwald, Julie A. Brennan, Michael S. Malamas, Boyd L. Harrison, Menelas N. Pangalos, Kevin Parris, Thomas Kronbach, Yike Ni, Kristi Fan, Rudolf Schindler, Rachel Navarra, Hans-Joachim Lankau, Nicholas J. Brandon, James Joseph Erdei, Barbara Langen
Publikováno v:
Journal of Medicinal Chemistry. 54:7621-7638
The identification of highly potent and orally active phenylpyrazines for the inhibition of PDE10A is reported. The new analogues exhibit subnanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and s
Autor:
Menelas N. Pangalos, James Joseph Erdei, Rudolf Schindler, Thorsten Hage, Christian Grunwald, Hans Stange, Michael S. Malamas, Julie A. Brennan, Barbara Langen, Nicholas J. Brandon, Norbert Hoefgen, Kristi Fan, Yike Ni, Boyd L. Harrison, Albert J. Robichaud, Karen L. Marquis, Radka Graf, Kevin Parris, Hans-Joachim Lankau, Steven M. Grauer, Rachel Navarra, Ute Egerland, Thomas Kronbach
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(18)
The identification of highly potent and orally active triazines for the inhibition of PDE10A is reported. The new analogs exhibit low-nanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and show des