Zobrazeno 1 - 10
of 295
pro vyhledávání: '"James J. Walker"'
Autor:
Valgerdur Steinthorsdottir, Ralph McGinnis, Nicholas O. Williams, Lilja Stefansdottir, Gudmar Thorleifsson, Scott Shooter, João Fadista, Jon K. Sigurdsson, Kirsi M. Auro, Galina Berezina, Maria-Carolina Borges, Suzannah Bumpstead, Jonas Bybjerg-Grauholm, Irina Colgiu, Vivien A. Dolby, Frank Dudbridge, Stephanie M. Engel, Christopher S. Franklin, Michael L. Frigge, Yr Frisbaek, Reynir T. Geirsson, Frank Geller, Solveig Gretarsdottir, Daniel F. Gudbjartsson, Quaker Harmon, David Michael Hougaard, Tatyana Hegay, Anna Helgadottir, Sigrun Hjartardottir, Tiina Jääskeläinen, Hrefna Johannsdottir, Ingileif Jonsdottir, Thorhildur Juliusdottir, Noor Kalsheker, Abdumadjit Kasimov, John P. Kemp, Katja Kivinen, Kari Klungsøyr, Wai K. Lee, Mads Melbye, Zosia Miedzybrodska, Ashley Moffett, Dilbar Najmutdinova, Firuza Nishanova, Thorunn Olafsdottir, Markus Perola, Fiona Broughton Pipkin, Lucilla Poston, Gordon Prescott, Saedis Saevarsdottir, Damilya Salimbayeva, Paula Juliet Scaife, Line Skotte, Eleonora Staines-Urias, Olafur A. Stefansson, Karina Meden Sørensen, Liv Cecilie Vestrheim Thomsen, Vinicius Tragante, Lill Trogstad, Nigel A. B. Simpson, FINNPEC Consortium, GOPEC Consortium, Tamara Aripova, Juan P. Casas, Anna F. Dominiczak, James J. Walker, Unnur Thorsteinsdottir, Ann-Charlotte Iversen, Bjarke Feenstra, Deborah A. Lawlor, Heather Allison Boyd, Per Magnus, Hannele Laivuori, Nodira Zakhidova, Gulnara Svyatova, Kari Stefansson, Linda Morgan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that geneti
Externí odkaz:
https://doaj.org/article/54b589a97a1246bc8db4f581846322e3
Autor:
Eva R. van der Vlugt, Petra E. Verburg, Shalem Y. Leemaqz, Lesley M. E. McCowan, Lucilla Poston, Louise C. Kenny, Jenny Myers, James J. Walker, Gustaaf A. Dekker, Claire T. Roberts, on behalf of the SCOPE Consortium
Publikováno v:
Biology of Sex Differences, Vol 11, Iss 1, Pp 1-10 (2020)
Abstract Background Asymmetric fetal growth and male sex are both associated with adverse neonatal outcome. However, less is known about the influence of asymmetric growth and fetal sex within SGA neonates, a group of infants already at increased ris
Externí odkaz:
https://doaj.org/article/ecb108fcd57b4b70826852e0e744b840
Publikováno v:
Placenta
The mechanical force of blood flow is a fundamental determinant of vascular homeostasis. This frictional stimulation of cells, fluid shear stress (FSS), is increasingly recognised as being essential to placental development and function. Here, we foc
Autor:
Lesley M E McCowan, John M D Thompson, Rennae S Taylor, Robyn A North, Lucilla Poston, Philip N Baker, Jenny Myers, Claire T Roberts, Gustaaf A Dekker, Nigel A B Simpson, James J Walker, Louise C Kenny, SCOPE Consortium
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70917 (2013)
Small for gestational age (SGA) infants comprise up to 50% of all stillbirths and a minority are detected before birth. We aimed to develop and validate early pregnancy predictive models for SGA infants.5628 participants from SCOPE, a prospective stu
Externí odkaz:
https://doaj.org/article/d217ee65be914cc4a8d395899d938156
Autor:
Dilbar Najmutdinova, Firuza Nishanova, Tatyana Hegay, John P. Kemp, Anna Helgadottir, Lucilla Poston, Saedis Saevarsdottir, Ralph McGinnis, Lilja Stefansdottir, Yr Frisbaek, Hrefna Johannsdottir, Olafur A. Stefansson, Thorunn A. Olafsdottir, Markus Perola, Scott Shooter, Frank Geller, Mads Melbye, Reynir Tómas Geirsson, Lill Trogstad, Thorhildur Juliusdottir, Kari Stefansson, Jonas Bybjerg-Grauholm, Eleonora Staines-Urias, Nodira Zakhidova, Daniel F. Gudbjartsson, Vinicius Tragante, João Fadista, Galina Berezina, Damilya Salimbayeva, Zosia Miedzybrodska, Katja Kivinen, James J. Walker, Kari Klungsøyr, Anna F. Dominiczak, Maria Carolina Borges, Fiona Broughton Pipkin, Nigel Simpson, Quaker E. Harmon, Per Magnus, Ashley Moffett, Tamara Aripova, Gordon Prescott, Sigrun Hjartardottir, Noor Kalsheker, Karina Meden Sørensen, Nicholas Williams, Hannele Laivuori, David M. Hougaard, Gulnara Svyatova, Debbie A Lawlor, Stephanie M. Engel, Gudmar Thorleifsson, Wai K. Lee, Paula J. Scaife, Christopher S. Franklin, Bjarke Feenstra, Irina Colgiu, Ann-Charlotte Iversen, Abdumadjit Kasimov, Jon K. Sigurdsson, Liv Cecilie Vestrheim Thomsen, Unnur Thorsteinsdottir, Line Skotte, Linda Morgan, Juan P Casas, Michael L. Frigge, Vivien A. Dolby, Frank Dudbridge, Valgerdur Steinthorsdottir, Suzannah Bumpstead, Kirsi M Auro, Ingileif Jonsdottir, Tiina Jääskeläinen, Heather A. Boyd, Solveig Gretarsdottir
Publikováno v:
Nature Communications
Steinthorsdottir, V, McGinnis, R, Williams, N O, Stefansdottir, L, Thorleifsson, G, Shooter, S, Fadista, J, Sigurdsson, J K, Auro, K M, Berezina, G, Borges, M C, Bumpstead, S, Bybjerg-Grauholm, J, Colgiu, I, Dolby, V A, Dudbridge, F, Engel, S M, Franklin, C S, Frigge, M L, Frisbaek, Y, Geirsson, R T, Geller, F, Gretarsdottir, S, Gudbjartsson, D F, Harmon, Q, Hougaard, D M, Hegay, T, Helgadottir, A, Hjartardottir, S, Jääskeläinen, T, Johannsdottir, H, Jonsdottir, I, Juliusdottir, T, Kalsheker, N, Kasimov, A, Kemp, J P, Kivinen, K, Klungsøyr, K, Lee, W K, Melbye, M, Miedzybrodska, Z, Moffett, A, Najmutdinova, D, Nishanova, F, Olafsdottir, T, Perola, M, Pipkin, F B, Skotte, L, Sørensen, K M, Kere, J, FINNPEC Consortium & GOPEC Consortium 2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, no. 1, 5976 . https://doi.org/10.1038/s41467-020-19733-6
et al. 2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, 5976 (2020) . https://doi.org/10.1038/s41467-020-19733-6
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, no. 1, 5976 . https://doi.org/10.1038/s41467-020-19733-6
Steinthorsdottir, V, McGinnis, R, Williams, N O, Stefansdottir, L, Thorleifsson, G, Shooter, S, Fadista, J, Sigurdsson, J K, Auro, K M, Berezina, G, Borges, M C, Bumpstead, S, Bybjerg-Grauholm, J, Colgiu, I, Dolby, V A, Dudbridge, F, Engel, S M, Franklin, C S, Frigge, M L, Frisbaek, Y, Geirsson, R T, Geller, F, Gretarsdottir, S, Gudbjartsson, D F, Harmon, Q, Hougaard, D M, Hegay, T, Helgadottir, A, Hjartardottir, S, Jääskeläinen, T, Johannsdottir, H, Jonsdottir, I, Juliusdottir, T, Kalsheker, N, Kasimov, A, Kemp, J P, Kivinen, K, Klungsøyr, K, Lee, W K, Melbye, M, Miedzybrodska, Z, Moffett, A, Najmutdinova, D, Nishanova, F, Olafsdottir, T, Perola, M, Pipkin, F B, Skotte, L, Sørensen, K M, Kere, J, FINNPEC Consortium & GOPEC Consortium 2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, no. 1, 5976 . https://doi.org/10.1038/s41467-020-19733-6
et al. 2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, 5976 (2020) . https://doi.org/10.1038/s41467-020-19733-6
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, no. 1, 5976 . https://doi.org/10.1038/s41467-020-19733-6
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the mater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c6a59b93fb4d8ac17970c34bafb35f
https://hdl.handle.net/11250/2754126
https://hdl.handle.net/11250/2754126
Autor:
Peter J. Webster, Lara C Morley, James J. Walker, Nigel Simpson, Jian Shi, Adam J. Hyman, David J. Beech, Karen Forbes, Hannah J. Gaunt, Courtney Williams
Publikováno v:
Molecular Human Reproduction
Morley, L C, Shi, J, Gaunt, H J, Hyman, A J, Webster, P J, Williams, C, Forbes, K, Walker, J J, Simpson, N A B & Beech, D J 2018, ' Piezo1 channels are mechanosensors in human fetoplacental endothelial cells ', Molecular Human Reproduction, vol. 24, no. 10, pp. 510-520 . https://doi.org/10.1093/molehr/gay033
Morley, L C, Shi, J, Gaunt, H J, Hyman, A J, Webster, P J, Williams, C, Forbes, K, Walker, J J, Simpson, N A B & Beech, D J 2018, ' Piezo1 channels are mechanosensors in human fetoplacental endothelial cells ', Molecular Human Reproduction, vol. 24, no. 10, pp. 510-520 . https://doi.org/10.1093/molehr/gay033
STUDY QUESTION: Does the shear stress sensing ion channel subunit Piezo1 have an important mechanotransduction role in human fetoplacental endothelium?SUMMARY ANSWER: Piezo1 is present and functionally active in human fetoplacental endothelial cells,
Autor:
Matias C. Vieira, Lesley M. E. McCowan, Claire T. Roberts, Elaine Fyfe, Lucilla Poston, James J. Walker, Alexandra Gillett, Robyn A. North, Dharmintra Pasupathy, Philip N. Baker, Jenny Myers, Louise C. Kenny
Publikováno v:
Obesity. 25:460-467
Objective To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2 ) and those with a normal BMI (20-25 kg/m2 ). Methods In 3,940 eligible nullip
Autor:
Emma Knight, Claire T. Roberts, Lesley M. E. McCowan, Shalem Leemaqz, Lucilla Poston, Prabha H. Andraweera, Jenny Myers, Louise C. Kenny, Jessica A. Grieger, James J. Walker, Luke E. Grzeskowiak, Gustaaf A. Dekker
Publikováno v:
The Medical journal of Australia. 212(11)
OBJECTIVES To evaluate whether cannabis use during pregnancy is associated with adverse neonatal outcomes that are independent of cigarette smoking. DESIGN Prospective cohort study. SETTING Adelaide (Australia), Auckland (New Zealand), Cork (Ireland)
Autor:
Lucilla Poston, Jenny Myers, Mahnaz Bahri Khomami, Lisa J. Moran, Robert J. Norman, Claire T. Roberts, Jessica A. Grieger, Louise C. Kenny, James J. Walker, Lesley M. E. McCowan, Gustaaf A. Dekker
Publikováno v:
Khomami, M B, Moran, L J, Kenny, L, Grieger, J A, Myers, J, Poston, L, Mccowan, L, Walker, J, Dekker, G, Norman, R & Roberts, C T 2019, ' Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study ', Clinical Endocrinology . https://doi.org/10.1111/cen.13954
CLINICAL ENDOCRINOLOGY
CLINICAL ENDOCRINOLOGY
Objectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors.Design: Prospective cohort Patients and measurements: Participants (n=5628) were apparently he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2515fe34fedc6c794cefd1cdf44c6d24
https://hdl.handle.net/10468/7585
https://hdl.handle.net/10468/7585
Autor:
Prabha H. Andraweera, Lucilla Poston, Shalem Leemaqz, Claire T. Roberts, Jenny Myers, Gus Dekker, Louise C. Kenny, Lesley M. E. McCowan, James J. Walker
Publikováno v:
The SCOPE Consortium 2019, ' Effect of Birth Weight and Early Pregnancy BMI on Risk for Pregnancy Complications ', Obesity, vol. 27, no. 2, pp. 237-244 . https://doi.org/10.1002/oby.22375
Andraweera, P H, Dekker, G, Leemaqz, S, McCowan, L, Myers, J, Kenny, L, Walker, J & Poston, L & Roberts, C T 2019, ' Effect of Birth Weight and Early Pregnancy BMI on Risk for Pregnancy Complications ', Obesity, vol. 27, no. 2, pp. 237-244 . https://doi.org/10.1002/oby.22375
Andraweera, P H, Dekker, G, Leemaqz, S, McCowan, L, Myers, J, Kenny, L, Walker, J & Poston, L & Roberts, C T 2019, ' Effect of Birth Weight and Early Pregnancy BMI on Risk for Pregnancy Complications ', Obesity, vol. 27, no. 2, pp. 237-244 . https://doi.org/10.1002/oby.22375
OBJECTIVE: This study investigated the influence of birth weight on the risk of pregnancy complications, including preeclampsia (PE), gestational hypertension (GH), small for gestational age (SGA) pregnancy, spontaneous preterm birth, and gestational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfdce467ddb49890125cea0bf4be996
https://pure.manchester.ac.uk/ws/files/213338097/Maternal_birthweight_and_pregnancy_outcomes_Draft_7_PA_SL_GD_CR_LM_JM_13_04_2018_CTR1.docx
https://pure.manchester.ac.uk/ws/files/213338097/Maternal_birthweight_and_pregnancy_outcomes_Draft_7_PA_SL_GD_CR_LM_JM_13_04_2018_CTR1.docx