The role of exercise-and high fat diet-induced bone marrow extracellular vesicles in stress hematopoiesis

Autor: James J. Vanhie, Wooseok Kim, Lisa Ek Orloff, Matthew Ngu, Nicolas Collao, Michael De Lisio

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Exercise and obesity regulate hematopoiesis, in part through alterations in cellular and soluble components of the bone marrow niche. Extracellular vesicles (EVs) are components of the bone marrow niche that regulate hematopoiesis; however, the role

Externí odkaz: https://doaj.org/article/d9f0d2e0b88a40bfbc7bbfbe1bd288e7

How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?

Autor: James J. Vanhie, Michael De Lisio

Publikováno v: Toxicologic pathology. 50(7)

Lifestyle factors are modifiable behavioral factors that have a significant impact on health and longevity. Diet-induced obesity and physical activity/exercise are two prevalent lifestyle factors that have strong relationships to overall health. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5455f92113190c25f38ba7d03e3b57c1
https://pubmed.ncbi.nlm.nih.gov/36114677

Recent advances in understanding the role of high fat diets and their components on hematopoiesis and the hematopoietic stem cell niche

Autor: Matthew Ngu, James J. Vanhie, Michael De Lisio

Publikováno v: Current Opinion in Food Science. 34:30-37

Hematopoietic stem/progenitor cells (HSPCs) are self-renewing, multipotent progenitors that sustain hematopoiesis and occupy the bone marrow. The increasing incidence of obesity has led to an expanding body of literature examining the effects of high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5900b04670a4c52d9dd1fa75a690b3d5
https://doi.org/10.1016/j.cofs.2020.11.004

Weight loss with exercise improves muscle architecture and progenitor cell populations compared with weight loss alone in mice with preneoplastic colorectal lesions

Autor: Nicolas Collao, Jessica Lloyd, Guanying Xu, Jillian Larkin, Diego Hernández-Saavedra, Russell Emmons, Hong Chen, Yuan Xiang Pan, Sophia Roubos, James J. Vanhie, Michael De Lisio, Donna D’souza

Publikováno v: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 46(7)

Weight loss and exercise reduce colorectal cancer (CRC) risk in persons with obesity. Whether weight loss and exercise effect myofibre characteristics and muscle stem/progenitor cell populations in mice with preneoplastic colorectal lesions, a model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098bb9542df513b23b848d59bda54ce8
https://pubmed.ncbi.nlm.nih.gov/33577399

Early experience with chemotherapy intensification for poor-prognosis metastatic germ cell cancer and unfavorable tumor marker decline.

Autor: Batra A; Division of Medical Oncology, Department of Oncology, Western University and London Health Sciences Centre, London, ON, Canada., Ernst S; Division of Medical Oncology, Department of Oncology, Western University and London Health Sciences Centre, London, ON, Canada., Potvin K; Division of Medical Oncology, Department of Oncology, Western University and London Health Sciences Centre, London, ON, Canada., Fernandes R; Division of Medical Oncology, Department of Oncology, Western University and London Health Sciences Centre, London, ON, Canada., Power N; Division of Urology, Department of Surgery, Western University and London Health Sciences Centre, London, ON, Canada., Vanhie J; London Health Sciences Centre, London, ON, Canada., Winquist E; Division of Medical Oncology, Department of Oncology, Western University and London Health Sciences Centre, London, ON, Canada.

Publikováno v: Canadian Urological Association journal = Journal de l'Association des urologues du Canada [Can Urol Assoc J] 2020 Feb; Vol. 14 (2), pp. 43-47. Date of Electronic Publication: 2019 Jul 23.