Zobrazeno 1 - 10
of 30
pro vyhledávání: '"James J. Valentine"'
Publikováno v:
Economy and Society. 52:227-249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b999c6286d0591232298b5713f074ab2
https://doi.org/10.1080/03085147.2023.2172252
https://doi.org/10.1080/03085147.2023.2172252
Autor:
Patricia Bourassa, Nicole Barucci, Stéphane De Lombaert, William J. Zavadoski, Daniel R. Goldberg, Qing Zhang, Robert J. Aiello, James J. Valentine, Vishwas M. Paralkar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1124-1129
The central role of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) as a neurotransmitter with important cognitive and behavioral functions is well known. However, 5-HT produced in the brain only accounts for approximately 5% of the tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ee42e411b02d02f0ced871cd344fd2
https://doi.org/10.1016/j.bmcl.2016.01.064
https://doi.org/10.1016/j.bmcl.2016.01.064
Autor:
Jean S. Beebe, William M. Hungerford, Nandini Chaturbhai Patel, Heather N. Frost, Susan Deborah Lagreca, Cathy Soderstrom, Shefali Kakar, Doug Savage, Matthew David Wessel, Matthew A. Marx, Merin Boehm, Thompson Carl Brian, Jinshan M. Chen, Connell Richard D, Nandell F. Keene, Elizabeth Knauth, Gary Borzillo, Aaron Kanter, Yong Lu, Joel Morris, Martin A. Berliner, Patrick Vincent, Bruce D. Cohen, George T. Tkalcevic, Joel T. Arcari, Deborah A. Gordon, James J. Valentine, Tracey Clark, Louis Martinez-Alsina, Vincent Bernardo, Felix Vajdos, Norma Jacqueline Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3059-3063
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4094fb50746e9612e49cef7a5bc7bf6
https://doi.org/10.1016/j.bmcl.2013.03.012
https://doi.org/10.1016/j.bmcl.2013.03.012
Autor:
Kari R. Fonseca, Rong Suobao, Bruce M. Bechle, Xinmin Gan, Michelle Marie Claffey, Amy B. Dounay, Jayvardhan Pandit, Edelweiss Evrard, Jamison B. Tuttle, Laura E. Zawadzke, Christine A. Strick, Brian M. Campbell, Katherine Schuyten, Artem G. Evdokimov, Vinod D. Parikh, Marie Anderson, Somraj Ghosh, Matthew R. Reese, James J. Valentine, Hong Wang, Patrick Robert Verhoest, Weldon Horner, Ji-Young Kim, Vanessa Paradis, Laura A. McAllister, Matthew Merrill Hayward, Michelle A. Salafia
Publikováno v:
ACS Medicinal Chemistry Letters. 3:187-192
Kynurenine aminotransferase (KAT) II has been identified as a potential new target for the treatment of cognitive impairment associated with schizophrenia and other psychiatric disorders. Following a high-throughput screen, cyclic hydroxamic acid PF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcbfbd5f6721faf10267dd4dae396be
https://doi.org/10.1021/ml200204m
https://doi.org/10.1021/ml200204m
Autor:
Kathrine Loomis, Kristin L. Rockwell, Meihua Tu, Paul A. Amor, Kirk McPherson, William P. Esler, Tereece Banks, Aaron C. Smith, Shawn Cabral, James J. Valentine, Susan Tapley, Kristen Ford, Colin R. Rose, Mark Niosi, Felix Vajdos, Carmen N. Garcia-Irizarry, Shawn D. Doran, James A. Southers, Scott W. Bagley, Margaret S. Landis, Alan M. Mathiowetz, Daniel W. Kung, David A. Griffith
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
A novel series of spirocyclic-diamine based, isoform non-selective inhibitors of acetyl-CoA carboxylase (ACC) is described. These spirodiamine derivatives were discovered by design of a library to mimic the structural rigidity and hydrogen-bonding pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97747d7f1eb5d78c33f023f1c9e7174
https://pubmed.ncbi.nlm.nih.gov/26411795
https://pubmed.ncbi.nlm.nih.gov/26411795
Publikováno v:
Aquaculture. 238:135-142
The efficacy of hydrogen peroxide to control mortality associated with saprolegniasis in channel catfish (Ictalurus punctatus) eggs was evaluated at the Lost Valley State Fish Hatchery (Warsaw, MO). Two efficacy trials were conducted. In Trial 1, cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ec0d4dba720d7f492a4467656e73c68
https://doi.org/10.1016/j.aquaculture.2004.06.007
https://doi.org/10.1016/j.aquaculture.2004.06.007
Autor:
Nancy E. Triggs, James J. Valentine
Publikováno v:
Israel Journal of Chemistry. 34:89-93
We report Raman and pre-resonant Raman spectra of the polyamides N,N- tetramethylene bisbutamide, N,N-hexamethylene bishexamide, and 7,14-diazacyclotetradecane-1,6-dione, as well as of a low molecular weight prepolymer of nylon 6,6 aimed at character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9f52d8201d90fac92119b913d0ce8d
https://doi.org/10.1002/ijch.199400013
https://doi.org/10.1002/ijch.199400013
Autor:
Kieran F. Geoghegan, Ravi G. Kurumbail, Xiayang Qiu, Melissa S. Harris, Allan R. Reyes, Richard K. Frisbie, Lise R. Hoth, James A. Landro, James J. Valentine, Francis Rajamohan
Publikováno v:
Protein expression and purification. 73(2)
AMP-activated protein kinase (AMPK) is an energy-sensing serine/threonine protein kinase that plays a central role in whole-body energy homeostasis. AMPK is a heterotrimeric enzyme with a catalytic (alpha) subunit and two regulatory (beta and gamma)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7409ee1b82ed5a3640a3d22ca5a3f6a5
https://pubmed.ncbi.nlm.nih.gov/20451617
https://pubmed.ncbi.nlm.nih.gov/20451617
CP-70,030 and CP-75,998: The first non-peptide antagonists of bombesin and gastrin releasing peptide
Autor:
Robin W. Spencer, James J. Valentine, Fredric J. Vinick, R. Michael Snider, Susumu Nakanishi, David L. Hageman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:333-338
CP-70,030 and CP-75,998 were identified in a screening program as compounds able to displace [125I]-gastrin releasing peptide (GRP) from its rat brain receptor. We describe here the syntheses of these compounds and their characterization as bonafide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66118efb0c1b65630beba283b239222b
https://doi.org/10.1016/s0960-894x(01)80213-4
https://doi.org/10.1016/s0960-894x(01)80213-4
Autor:
Christopher J. Schmidt, Sanner Mark Allen, Karen M. Ward, Susan E. Drozda, James J. Valentine, John A. Lowe, Shari L. DeNinno, Don Tunucci, F. David Tingley
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
We describe a novel series of inhibitors of the type 1 glycine transporter (GlyT1) as an approach to relieving the glutamatergic deficit that is thought to underlie schizophrenia. Synthesis and SAR follow-up of a series of octahydro-cyclopenta[c]pyrr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2c52414b50a652ae30f7bab1cd5d4c
https://pubmed.ncbi.nlm.nih.gov/20045321
https://pubmed.ncbi.nlm.nih.gov/20045321