Zobrazeno 1 - 10
of 48
pro vyhledávání: '"James J. Thornton"'
Drug delivery of zinc to Barrett’s metaplasia by oral administration to Barrett’s esophagus patients
Autor:
Nicole E. Albert, Dinu Cherian, Benjamin Raile, Christopher P. Farrell, John Abramson, Robert Bailey, Giancarlo Mercogliano, Mary Carmen Valenzano, Marc Zitin, Erin McDonnell, Maura Barr, James M. Mullin, E Peter Zurbach, Gary Daum, Melissa Morgan, Austin Hwang, Joanna M. Mercado, Jonathan M. Raines, James J Thornton, Xuexuan Wang, Gary Newman, David S. Rudolph
Publikováno v:
Therapeutic Delivery. 5:257-264
Background: Delivery of a pharmacologically effective drug dosage to a target tissue is critical. Barrett’s epithelia are a unique challenge for drug delivery of orally administered zinc due to rapid transit down the esophageal lumen, incomplete ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fa1fd510660f0dce864bfacfc914f1
https://doi.org/10.4155/tde.13.151
https://doi.org/10.4155/tde.13.151
Autor:
Arun Mathew, Scott McShane, Elizabeth Rybakovsky, James M. Mullin, Silpa Yalamanchili, Marc Zitin, Mary Carmen Valenzano, Ryan Urbas, Will Huntington, James J. Thornton, Louise Fong, Elizabeth Richardson, Gary Newman, Giancarlo Mercogliano, Patricia Wong, Erin McDonnell
Publikováno v:
American Journal of Gastroenterology. 113:S184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b898bca22983773fa9ae77f8c882dd43
https://doi.org/10.14309/00000434-201810001-00329
https://doi.org/10.14309/00000434-201810001-00329
Autor:
James M. Mullin, M. Whitby, Giancarlo Mercogliano, Keith R. Kearney, D. Lazowick, Mary Carmen Valenzano, V. Jain, J. D. Schmidt, D. Lurie, O. Tully, James J Thornton
Publikováno v:
Alimentary Pharmacology & Therapeutics. 28:1317-1325
Proton pump inhibitors (PPIs) are one of the most widely used drug classes in the US and are now frontline medications for gastro-oesophageal reflux disease (GERD) and dyspepsia. In a previous work, we observed that a transmucosal, upper gastrointest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f697441028d77186bdc0680fa613f0b2
https://doi.org/10.1111/j.1365-2036.2008.03824.x
https://doi.org/10.1111/j.1365-2036.2008.03824.x
Autor:
P. D. Allegretti, S. Trembeth, J. J. Verrecchio, Jon Meddings, James J Thornton, Mary Carmen Valenzano, Giancarlo Mercogliano, James M. Mullin, V. Jain, J. D. Schmidt
Publikováno v:
Digestive Diseases and Sciences. 51:2326-2336
Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf2fb9f9b7859274c8c547852665d29
https://doi.org/10.1007/s10620-006-9478-5
https://doi.org/10.1007/s10620-006-9478-5
Publikováno v:
Drug Discovery Today. 10:395-408
There is a spectrum of distinct disease states that have in common their effect of breaking down epithelial and/or endothelial barrier function. Fluid compartmentalization goes awry, with profound implications for epithelial and stromal homeostasis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee74dc8fa0403ea5a5ad449422ebadc
https://doi.org/10.1016/s1359-6446(05)03379-9
https://doi.org/10.1016/s1359-6446(05)03379-9
Autor:
Christopher P. Farrell, James M. Mullin, Kevin Wolov, James J Thornton, Melissa Gabello, Jillan Bellows, David S. Rudolph, Keith R. Kearney, Lisa J. Murray
Publikováno v:
Drug discovery today. 14(13-14)
Proton pump inhibitors are the second most commonly prescribed drug class in the United States. The increased utilization of PPIs parallels the rising incidence of reflux disease. Owing to their clinical efficacy and relative lack of tachyphylaxis, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c61ea0f7c6d74bc74a6ef8f63fbaba8
https://pubmed.ncbi.nlm.nih.gov/19443264
https://pubmed.ncbi.nlm.nih.gov/19443264
Autor:
Rupal Kothari, Giancarlo Mercogliano, Erika Rendon-Huerta, James M. Mullin, Susan E Trembeth, Burhan Hameed, Mary Carmen Valenzano, James J. Thornton
Publikováno v:
The American journal of gastroenterology. 98(8)
Comparison of three integral tight junction barrier proteins in Barrett's epithelium versus normal esophageal epithelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d3a1629164f32ef41c6a6e852fea4d
https://pubmed.ncbi.nlm.nih.gov/12907361
https://pubmed.ncbi.nlm.nih.gov/12907361
Autor:
Benjamin Ngo, Giancarlo Mercogliano, Keith R. Kearney, Mary Carmen Valenzano, Kevin Wolov, Melissa Morgan, Christopher J. Farrell, Owen Tully, James J. Thornton, James M. Mullin
Publikováno v:
World Journal of Gastroenterology. 18:2793
AIM: To determine if the observed paracellular sucrose leak in Barrett’s esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett’s patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e038955e81b56ad49700d823e9e05bba
https://doi.org/10.3748/wjg.v18.i22.2793
https://doi.org/10.3748/wjg.v18.i22.2793
Autor:
James J. Thornton, W. Randall Russell, Jacqueline N. Tongue, James M. Mullin, David V. Reindl, K. V. Laughlin, Jörg-Dieter Schulzke
Publikováno v:
Digestive Diseases and Sciences. 45:2374-2375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c37c0280312a70dfbd7017d7e64dc0
https://doi.org/10.1023/a:1005643125837
https://doi.org/10.1023/a:1005643125837
Autor:
Keith R. Kearney, Mary Carmen Valenzano, Giancarlo Mercogliano, Marysue Whitby, James M. Mullin, James J. Thornton, Owen Tully
Publikováno v:
Gastrointestinal Endoscopy. 69:AB349
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d00df3213dfcf5307a5198ab50e2c9f
https://doi.org/10.1016/j.gie.2009.03.1025
https://doi.org/10.1016/j.gie.2009.03.1025