Zobrazeno 1 - 10 of 33 pro vyhledávání: '"James J. Saller"'
1
Akademický článek
RET splice site variants in medullary thyroid carcinoma
Autor: Daryoush Saeed-Vafa, Kyriakos Chatzopoulos, Juan Hernandez-Prera, Pedro Cano, James J. Saller, Julie E. Hallanger Johnson, Bryan McIver, Theresa A. Boyle
Publikováno v: Frontiers in Genetics, Vol 15 (2024)
Introduction: Medullary thyroid carcinoma (MTC) is an aggressive cancer that is often caused by driver mutations in RET. Splice site variants (SSV) reflect changes in mRNA processing, which may alter protein function. RET SSVs have been described in
Externí odkaz: https://doaj.org/article/43f3651c022f4709b71eca41e706cfce
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2
Akademický článek
PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Autor: Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth, Gina M. DeNicola
Publikováno v: Cancer & Metabolism, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical for the proliferation
Externí odkaz: https://doaj.org/article/10e50bc8495c4a54bb2a375c109217bd
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3
Akademický článek
A community‐based lung cancer rapid tissue donation protocol provides high‐quality drug‐resistant specimens for proteogenomic analyses
Autor: Theresa A. Boyle, Gwendolyn P. Quinn, Matthew B. Schabath, Teresita Muñoz‐Antonia, James J. Saller, Luisa F. Duarte, Laura S. Hair, Jamie K. Teer, Derek Y. Chiang, Rebecca Leary, Connie C. Wong, Alexander Savchenko, Angad P. Singh, LaSalette Charette, Kate Mendell, Gullu Gorgun, Scott J. Antonia, Alberto A. Chiappori, Benjamin C. Creelan, Jhanelle E. Gray, Eric B. Haura
Publikováno v: Cancer Medicine, Vol 9, Iss 1, Pp 225-237 (2020)
Abstract Background For the advancement of cancer research, the collection of tissue specimens from drug‐resistant tumors after targeted therapy is crucial. Although patients with lung cancer are often provided targeted therapy, post‐therapy spec
Externí odkaz: https://doaj.org/article/82ae3eb5e1ff40e2b1ca8ba0ac5ee571
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4
Akademický článek
Proteogenomic landscape of squamous cell lung cancer
Autor: Paul A. Stewart, Eric A. Welsh, Robbert J. C. Slebos, Bin Fang, Victoria Izumi, Matthew Chambers, Guolin Zhang, Ling Cen, Fredrik Pettersson, Yonghong Zhang, Zhihua Chen, Chia-Ho Cheng, Ram Thapa, Zachary Thompson, Katherine M. Fellows, Jewel M. Francis, James J. Saller, Tania Mesa, Chaomei Zhang, Sean Yoder, Gina M. DeNicola, Amer A. Beg, Theresa A. Boyle, Jamie K. Teer, Yian Ann Chen, John M. Koomen, Steven A. Eschrich, Eric B. Haura
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Squamous cell lung cancer has dismal prognosis due to the dearth of effective treatments. Here, the authors perform an integrated proteogenomic analysis of the disease, revealing three proteomics-based subtypes and suggesting potential therapeutic op
Externí odkaz: https://doaj.org/article/841bd6d6165d4e9f8532ae0a3ce6a908
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