Zobrazeno 1 - 10
of 36
pro vyhledávání: '"James J. Sahn"'
Autor:
Hua Wang, Zhiyou Peng, Yiwen Li, James J. Sahn, Timothy R. Hodges, Tsung-Han Chou, Qiong Liu, Xuezhi Zhou, Shuliang Jiao, Vittorio Porciatti, Daniel J. Liebl, Stephen F. Martin, Rong Wen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The sigma 2 receptor (σ2R) was recently identified as an endoplasmic reticulum (ER) membrane protein known as transmembrane protein 97 (TMEM97). Studies have shown that σ2R/TMEM97 binding compounds are neuroprotective, suggesting a role of
Externí odkaz:
https://doaj.org/article/1d3b2f964175428cacf0b3d8c79c728f
Autor:
Jing Jin, Nicolas Arbez, James J. Sahn, Yan Lu, Kathryn T. Linkens, Timothy R. Hodges, Anthony Tang, Robyn Wiseman, Stephen F. Martin, Christopher A. Ross
Publikováno v:
ACS Chemical Neuroscience. 13:2852-2862
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d4d59d455e06d6fccd131af702a97c
https://doi.org/10.1021/acschemneuro.2c00274
https://doi.org/10.1021/acschemneuro.2c00274
Autor:
Muhammad Saad Yousuf, James J. Sahn, Eric T. David, Stephanie Shiers, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Ayesha Ahmad, Benedict J. Kolber, Daniel J Liebl, Stephen F. Martin, Theodore J. Price
The Sigma 2 receptor (σ2R) was described pharmacologically more than three decades ago, but its molecular identity remained obscure until recently when it was identified as transmembrane protein 97 (TMEM97). We and others have shown that σ2R/TMEM97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b418aee99984bd348deff7da78b005
https://doi.org/10.1101/2023.04.11.536439
https://doi.org/10.1101/2023.04.11.536439
Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5’-cap binding protein, eukaryotic translation init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ca521f655b8a8eb2d9257e8313cda6
https://doi.org/10.1101/2023.01.04.522773
https://doi.org/10.1101/2023.01.04.522773
Publikováno v:
European journal of medicinal chemistry. 243
Initially associated with cancer diagnosis and therapy, the sigma 2 receptor (σ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4dc56dc53be4051d2aca99e0800bf666
https://pubmed.ncbi.nlm.nih.gov/36088757
https://pubmed.ncbi.nlm.nih.gov/36088757
Autor:
Hua, Wang, Zhiyou, Peng, Yiwen, Li, James J, Sahn, Timothy R, Hodges, Tsung-Han, Chou, Qiong, Liu, Xuezhi, Zhou, Shuliang, Jiao, Vittorio, Porciatti, Daniel J, Liebl, Stephen F, Martin, Rong, Wen
Publikováno v:
Scientific reports. 12(1)
The sigma 2 receptor (σ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f79d0cca13b851f0e9c7bfa58c2c693
https://pubmed.ncbi.nlm.nih.gov/36456686
https://pubmed.ncbi.nlm.nih.gov/36456686
Publikováno v:
Pharmacol Rev
Dysfunction in regulation of mRNA translation is an increasingly recognized characteristic of many diseases and disorders, including cancer, diabetes, autoimmunity, neurodegeneration, and chronic pain. Approximately 50 million adults in the United St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1675972cbce00c5a4ff627d9db18f160
https://doi.org/10.1124/pharmrev.120.000030
https://doi.org/10.1124/pharmrev.120.000030
Publikováno v:
European Journal of Medicinal Chemistry. 243:114696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73551a8d83e14ebe65b983d5a280f374
https://doi.org/10.1016/j.ejmech.2022.114696
https://doi.org/10.1016/j.ejmech.2022.114696
Autor:
Luíza dos Reis Cruz, Valentina Sabino, Sean M Tanino, Emily J Yao, Sema G. Quadir, Christian D. Rohl, James J. Sahn, Stephen F. Martin, Pietro Cottone
Publikováno v:
Neuropharmacology
Alcohol Use Disorder (AUD) is a chronic relapsing disorder characterized by compulsive alcohol intake, loss of control over alcohol intake, and a negative emotional state when access to alcohol is prevented. AUD is also closely tied to pain, as repea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cf9594942eec37be175663c0aff773
https://europepmc.org/articles/PMC7856185/
https://europepmc.org/articles/PMC7856185/
Autor:
Andrew A. Pieper, Min-Kyoo Shin, James J. Sahn, Daniel J. Liebl, Edwin Vázquez-Rosa, Stephen F. Martin, Coral J. Cintrón-Pérez, Terry C. Yin, Josie L. Emery, Michael R. Watson, Timothy R. Hodges, Rachel Schroeder
Publikováno v:
ACS Chemical Neuroscience. 10:1595-1602
Compounds targeting the sigma 2 receptor, which we recently cloned and showed to be identical with transmembrane protein 97 (σ2R/TMEM97), are broadly applicable therapeutic agents currently in clinical trials for imaging in breast cancer and for tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb994ce4bb6f644ed226e8ffc18f2e3d
https://doi.org/10.1021/acschemneuro.8b00543
https://doi.org/10.1021/acschemneuro.8b00543