Zobrazeno 1 - 10
of 86
pro vyhledávání: '"James J. Phelan"'
Autor:
Dearbhla M. Murphy, Anastasija Walsh, Laura Stein, Andreea Petrasca, Donal J. Cox, Kevin Brown, Emily Duffin, Gráinne Jameson, Sarah A. Connolly, Fiona O’Connell, Jacintha O’Sullivan, Sharee A. Basdeo, Joseph Keane, James J. Phelan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2898 (2024)
Neutrophils are dynamic cells, playing a critical role in pathogen clearance; however, neutrophil infiltration into the tissue can act as a double-edged sword. They are one of the primary sources of excessive inflammation during infection, which has
Externí odkaz:
https://doaj.org/article/0fcdcf15fdda40538d7cbf17238d2b37
Autor:
Maria Davern, Caoimhe Gaughan, Fiona O’ Connell, Brendan Moran, Eimear Mylod, Andrew D. Sheppard, Sinead Ramjit, Jasmine Yun-Tong Kung, James J. Phelan, Matthew G. Davey, Eanna J. Ryan, Christine Butler, Laura Quinn, Claudine Howard, Emily Tone, Eimear Phoenix, Waqas T. Butt, Niamh Lynam-Lennon, Stephen G. Maher, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Noel E. Donlon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThis timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal canc
Externí odkaz:
https://doaj.org/article/e9a76b77fe4448bca0dc1485f4477ae2
Autor:
Dearbhla M. Murphy, Donal J. Cox, Sarah A. Connolly, Eamon P. Breen, Aenea A.I. Brugman, James J. Phelan, Joseph Keane, Sharee A. Basdeo
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Background Heterologous effects of vaccines are mediated by “trained immunity,” whereby myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened responses to subsequent insults. Adenovirus vaccine vector has been r
Externí odkaz:
https://doaj.org/article/24b44d5422e842b18d691bd5b2e4fc5e
Autor:
Abigail Keogan, Thi Nguyet Que Nguyen, James J. Phelan, Naoimh O'Farrell, Niamh Lynam‐Lennon, Brendan Doyle, Dermot O'Toole, John V. Reynolds, Jacintha O'Sullivan, Aidan D. Meade
Publikováno v:
Translational Biophotonics, Vol 3, Iss 4, Pp n/a-n/a (2021)
Abstract Fourier Transform Infrared (FTIR) based chemical imaging is a powerful, non‐destructive and label‐free biophotonic technique, which spatially acquires bio‐molecularly relevant information in histopathology. Cancer detection with object
Externí odkaz:
https://doaj.org/article/63b24369954a41efb8aabbedac63d2eb
Autor:
Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Externí odkaz:
https://doaj.org/article/a9b01451cc7f44639429c99ff0a2bc3b
Autor:
Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Fergal D. Malone, Joseph Keane, Sharee A. Basdeo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Warburg effect, defined as increased glycolysis and decreased oxidative phosphorylation, occurs in murine macrophages following LPS stimulation and is required for activation. There are differences between human and murine macrophage metabolic re
Externí odkaz:
https://doaj.org/article/dd41be26f8eb47d9beaaaaf1885151c4
Autor:
Donal J. Cox, Amy M. Coleman, Karl M. Gogan, James J. Phelan, Cilian Ó Maoldomhnaigh, Pádraic J. Dunne, Sharee A. Basdeo, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived macrophages (MDM) in the lung. Inf
Externí odkaz:
https://doaj.org/article/02d0040159e54ec2a417da3bfd05a263
Autor:
Christina Cahill, Dónal J. Cox, Fiona O’Connell, Sharee A. Basdeo, Karl M. Gogan, Cilian Ó’Maoldomhnaigh, Jacintha O’Sullivan, Joseph Keane, James J. Phelan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12189 (2021)
Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-resistant TB undergo long, arduous, and complex treatment regimens, often involving multiple antimicrobials. While these drugs were initially implemented based
Externí odkaz:
https://doaj.org/article/890985290cbb45fd9a7aa24df19e0be4
Autor:
Noel E. Donlon, Maria Davern, Andrew Sheppard, Robert Power, Fiona O’Connell, Aisling B. Heeran, Ross King, Conall Hayes, Anshul Bhardwaj, James J. Phelan, Margaret R. Dunne, Narayanasamy Ravi, Claire L. Donohoe, Jacintha O’Sullivan, John V. Reynolds, Joanne Lysaght
Publikováno v:
Cancers, Vol 13, Iss 16, p 4005 (2021)
Response rates to the current gold standards of care for treating oesophageal adenocarcinoma (OAC) remain modest with 15–25% of patients achieving meaningful pathological responses, highlighting the need for novel therapeutic strategies. This study
Externí odkaz:
https://doaj.org/article/f9614f8892c540978cec164f122a4666
Autor:
Christina Cahill, Fiona O’Connell, Karl M. Gogan, Donal J. Cox, Sharee A. Basdeo, Jacintha O’Sullivan, Stephen V. Gordon, Joseph Keane, James J. Phelan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2938 (2021)
For over 50 years, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and complex treatment processes with several antimicrobials. With the prevalence of drug-resistant strains on the rise and new therapies for
Externí odkaz:
https://doaj.org/article/75406c1e4d7a4d6cb6d088a2569f6700