Zobrazeno 1 - 10
of 61
pro vyhledávání: '"James J. Perkins"'
Publikováno v:
Organic Letters. 22:2196-2200
An expedient synthesis of β-alkyl α-amino acids is reported via application of decarboxylative photocatalysis. The method utilizes abundant, diverse, and inexpensive carboxylic acids to provide radicals for conjugate addition to dehydroalanine este
Publikováno v:
European Journal of Organic Chemistry. 2020:1515-1522
Publikováno v:
ACS Med Chem Lett
[Image: see text] Nucleoside analogues have been and continue to be extremely important compounds in drug discovery. Despite the significant effort dedicated to their synthesis, medicinal chemistry campaigns around these structures are often hampered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824b8b2ee4e770fa0b08dc09bc951f90
https://europepmc.org/articles/PMC8040254/
https://europepmc.org/articles/PMC8040254/
Development of a sp2–sp3 Stille Cross-Coupling for Rapid Synthesis of HIV NNRTI Doravirine Analogues
Publikováno v:
Organic Letters. 19:3071-3074
The development of a C(sp2)–C(sp3) cross-coupling reaction for rapid, parallel synthesis of analogues of two HIV NNRTI clinical candidates is described. This method allowed easy access to the C-ring space using a practical alkylation with commercia
Publikováno v:
Organic letters. 19(12)
The development of a C(sp
Autor:
William J. Ray, Chang Bai, Stephen E. Alves, Tara E. Cusick, Brenda L Pennypacker, Evan E. Opas, Michael J. Chisamore, Carlo J. Gambone, Damien Ferraro, David J. Bettoun, Azriel Schmidt, Hilary A. Wilkinson, Angela Scafonas, Michael A. Gentile, Osvaldo A. Flores, Paul Hodor, Meissner Robert S, James J. Perkins
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 143:29-39
Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by improving hormone
Autor:
Pascale V. Nantermet, Thomayant Prueksaritanont, William J. Ray, James J. Perkins, Chih-Tai Leu, Fang Chen, Azriel Schmidt, Mark E. Duggan, Viera Kasparcova, Sharon Adamski, Donald B. Kimmel, Leonard P. Freedman, SuJane Rutledge, T. Cusick, Brenda L Pennypacker, George D. Hartman, Jiabing Wang, P. Masarachia, Meissner Robert S, Shun-ichi Harada, Paul Hodor, Robert L. Vogel, Chang Bai, Hai-Zhuan Zhang, Sheila McElwee-Witmer, Helen J. Mitchell, Michael A. Gentile, Evan E. Opas, Angela Scafonas, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 285:17054-17064
Selective androgen receptor modulators (SARMs) are androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially activate, or even antagoniz
Autor:
Amy E. Zartman, William F. Hoffman, David B. Whitman, James J. Perkins, Chih-Tai Leu, Sevgi B. Rodan, Gideon A. Rodan, Mark E. Duggan, Gregg Wesolowski, Nathan C. Ihle, John E. Fisher, Le T. Duong, Terence G. Hamill, Rose M. Nagy, Joel R. Huff, George D. Hartman
Publikováno v:
Journal of Medicinal Chemistry. 43:3736-3745
Modification of the potent fibrinogen receptor (αIIbβ3) antagonist 1 generated compounds with high affinity for the vitronectin receptor αvβ3. Sequential modification of the basic N-terminus of 1 led to the identification of the 5,6,7,8-tetrahydr
Autor:
Adel M. Naylor-Olsen, Jacquelynn J. Cook, Robert J. Meissner, Amy E. Zartman, William F. Hoffman, Robert J. Gould, Guixiang Zhang, George D. Hartman, Joan D. Glass, R. J. Lynch, Mark E. Duggan, James J. Perkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:863-868
A new series of potent, linearly-minimized, orally active, selective GPIIb/IIIa inhibitors is identified. Thus 15 (L-750,034) achieves interaction via a constrained, non-turned conformation that maintains the proper distance between its charged termi
Publikováno v:
Tetrahedron Letters. 40:1103-1106
A general and highly convenient procedure for the synthesis of 2-(alkylamino)benzimidazoles has been developed and a variety of analogs have been efficiently prepared. Included is a dipeptide mimetic in which the guanidine group of an arginine residu