Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James J. P. Alix"'
Autor:
Amy Keerie, Heledd Brown-Wright, Isaac Kirkland, Andrew Grierson, James J. P. Alix, Christian Holscher, Richard J. Mead
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract GLP-1 receptor agonists used for the treatment of diabetes, have shown some neuroprotective effects in cellular and animal models of Alzheimer’s disease (AD) and Parkinson’s disease (PD). There are currently few studies investigating GLP
Externí odkaz:
https://doaj.org/article/8ad89c55f0164a14a6f498f5d3f6500b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The majority of preclinical studies in ALS have relied on transgenic models with overexpression of mutant human superoxide dismutase 1 (SOD1), widely regarded to have failed in terms of translation of therapeutic effects. However, there are
Externí odkaz:
https://doaj.org/article/b3bf81e102784ceca1bb400b40642252
Publikováno v:
BMC Pediatrics, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Neonatal seizures are difficult to diagnose and, when they are, tradition dictates first line treatment is phenobarbital. There is little data on how consultants diagnose neonatal seizures, choose when to treat or how they choose
Externí odkaz:
https://doaj.org/article/1062f1079704482cb72cbc4150190235
Autor:
Jodie Watkins, Anshua Ghosh, Amy F. A. Keerie, James J. P. Alix, Richard J. Mead, Jemeen Sreedharan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/e1b8b513256d43b8b3ae165a71f2a4ca
Autor:
Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins, Pamela J. Shaw
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous group of conditions, all of which are relentlessly progressive and ultimately fatal. The average life expectancy is 2 years, but with a broad range of months to decades
Externí odkaz:
https://doaj.org/article/66fb8ce3c32f4a57b9cfe52fdde25035
Autor:
James J. P. Alix, Maria Plesia, Chlöe N. Schooling, Alexander P. Dudgeon, Catherine A. Kendall, Visakan Kadirkamanathan, Christopher J. McDermott, Gráinne S. Gorman, Robert W. Taylor, Richard J. Mead, Pamela J. Shaw, John C. Day
Publikováno v:
Journal of Raman Spectroscopy. 54:258-268
Autor:
James J. P. Alix, Nick S. Verber, Chlöe N. Schooling, Visakan Kadirkamanathan, Martin R. Turner, Andrea Malaspina, John C. C. Day, Pamela J. Shaw
Publikováno v:
Alix, J J P, Verber, N S, Schooling, C N, Kadirkamanathan, V, Turner, M R, Malaspina, A, Day, J C C & Shaw, P J 2022, ' Label-free fibre optic Raman spectroscopy with bounded simplex-structured matrix factorization for the serial study of serum in amyotrophic lateral sclerosis ', Analyst, vol. 147, no. 22, pp. 5113-5120 . https://doi.org/10.1039/d2an00936f
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease in urgent need of disease biomarkers for the assessment of promising therapeutic candidates in clinical trials. Raman spectroscopy is an attractive technique for identifyin
Autor:
James J. P. Alix, Maria Plesia, Sarah A. Hool, Ian Coldicott, Catherine A. Kendall, Pamela J. Shaw DBE, Richard J. Mead, John C. Day
Publikováno v:
Alix, J J P, Plesia, M, Hool, S A, Coldicott, I, Kendall, C A, Shaw Dbe, P J, Mead, R J & Day, J C 2022, ' Fiber optic Raman spectroscopy for the evaluation of disease state in Duchenne muscular dystrophy : An assessment using the mdx model and human muscle ', Muscle and Nerve, vol. 66, no. 3, pp. 362-369 . https://doi.org/10.1002/mus.27671
INTRODUCTION/AIMS: Raman spectroscopy is an emerging technique for the evaluation of muscle disease. In this study we evaluate the ability of in vivo intramuscular Raman spectroscopy to detect the effects of voluntary running in the mdx model of Duch
Autor:
James J. P. Alix, Maria Plesia, Gavin R. Lloyd, Alexander P. Dudgeon, Catherine A. Kendall, Channa Hewamadduma, Marios Hadjivassiliou, Christopher J. McDermott, Gráinne S. Gorman, Robert W. Taylor, Pamela J. Shaw, John C. C. Day
Publikováno v:
Alix, J J P, Plesia, M, Lloyd, G R, Dudgeon, A P, Kendall, C A, Hewamadduma, C, Hadjivassiliou, M, McDermott, C J, Gorman, G S, Taylor, R W, Shaw, P J & Day, J C C 2022, ' Rapid identification of human muscle disease with fibre optic Raman spectroscopy ', Analyst, vol. 147, no. 11, pp. 2533-2540 . https://doi.org/10.1039/d1an01932e
The diagnosis of muscle disorders ("myopathies") can be challenging and new biomarkers of disease are required to enhance clinical practice and research. Despite advances in areas such as imaging and genomic medicine, muscle biopsy remains an importa
Autor:
Helia, Ghahremani Nezhad, John P, Franklin, James J P, Alix, Tobias, Moll, Michael, Pattrick, Johnathan, Cooper-Knock, Priya, Shanmugarajah, Nick J, Beauchamp, Marios, Hadjivissiliou, David, Paling, Christopher, Mcdermott, Pamela J, Shaw, Thomas M, Jenkins
Publikováno v:
Amyotrophic lateral sclerosisfrontotemporal degeneration. 22(7-8)
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) share a common molecular basis: both are associated with CAG-repeat expansion of