Zobrazeno 1 - 10 of 12 pro vyhledávání: '"James J. Mrotek"'
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Autor: J R Owens, James J. Mrotek, S A Mathias, O. P. Mgbonyebi, E Motley
Publikováno v: Cell Biology and Toxicology. 14:225-236
In previous studies, nonlethal CdCl2 concentrations apparently inhibited basal Y-1 mouse adrenal tumor cell endogenous mitochondrial cholesterol conversion to pregnenolone. In addition, CdCl2 inhibited all agents stimulating both plasma membrane-depe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ff680d1f6ef13589fe5516091666e12
https://doi.org/10.1023/a:1007422928427
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2
Modulation of adrenal cell functions by cadmium salts. 1. Cadmium chloride effects on basal and ACTH-stimulated steroidogenesis
Autor: Ozuem P. Mgbonyebi, James J. Mrotek, Corigan T. Smothers
Publikováno v: Cell Biology and Toxicology. 9:223-234
Cultured Y-1 mouse adrenal tumor cells, which secrete 20-alpha-hydroxy-4-pregnen-3-one (20-DHP), were used to investigate the acute nonlethal effects of incremental cadmium chloride (CdCl2) concentrations on basal and maximally stimulated steroid sec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403748fa92c580b5083c847b9ee6263b
https://doi.org/10.1007/bf00755601
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4
Cadmium-induced sexual dysfunction does not involve increased hepatic metabolism of testosterone nor increased circulating levels of corticosterone
Autor: Mary Winfree, Stanley L. Evans, Roxanne Barrow, James J. Mrotek, Braulio Jimenez, John T. Clark
Publikováno v: Physiologybehavior. 56(5)
Sexually experienced male rats were injected IP with 0, 0.3, 1.5, 3.0, or 6.0 mg/kg cadmium chloride. The highest dose was fatal within 48 h of injection. A dose-related deficit in erectile function was observed in ex copula tests 48 h after injectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d8ac02e2706d28fd75ce6ac727fcc0
https://pubmed.ncbi.nlm.nih.gov/7824600
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5
Modulation of adrenal cell functions by cadmium salts: 3. Sites affected by CdCl2 during stimulated steroid synthesis
Autor: C. T. Smothers, James J. Mrotek, O. P. Mgbonyebi
Publikováno v: Cell biology and toxicology. 10(1)
In previous studies cadmium chloride (CdCl2) nonlethally inhibited Y-1 mouse adrenal tumor cell 20-dihydroxyprogesterone (20DHP) secretion, affecting unstimulated and stimulated steroidogenic pathway sites differently. In addition, dibutyryl cAMP-sti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34e860b5a97aec7937a1bed72fab2df
https://pubmed.ncbi.nlm.nih.gov/8076221
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7
The influence of cytochalasin B on the response of adrenal tumor cells to acth and cyclic AMP
Autor: James J. Mrotek, Peter F. Hall
Publikováno v: Biochemical and Biophysical Research Communications. 64:891-896
Cytochalasin B inhibits increase in steroid synthesis by mouse adrenal tumor cells (Y-1), produced either by ACTH or cyclic AMP. Basal levels of steroid synthesis are not decreased and the inhibitor acts by decreasing the response of the side-chain c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5204177f339a1068b7e8e75a41794d
https://doi.org/10.1016/0006-291x(75)90131-x
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8
Exogenous steroids alter steroidogenesis in cultured Y-1 adrenal tumor cells by actions preceding cyclic AMP
Autor: James J. Mrotek, Mark P. Mattson
Publikováno v: Steroids. 46:619-637
Using cultured Y-1 mouse adrenal tumor cells which produce 20 alpha-hydroxy-4-pregnen-3-one (20-DHP), it was found that 0.01 mM corticosterone and deoxycorticosterone increased basal and inhibited ACTH-induced 20-DHP production during consecutive 30
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7326a87c83eca9da05a9dfb12f15ad0
https://doi.org/10.1016/0039-128x(85)90026-1
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9
Extraction of corticosterone from cell homogenates and subcellular fractions of the rat adrenal cortex. III. ACTH-induced temporal subcellular redistributions of steroid precursors to corticosterone
Autor: Joseph C. Curtis, Verney L. Sallee, Joseph Mathew, James J. Mrotek
Publikováno v: Steroids. 46:697-716
Cholesterol, pregnenolone, progesterone, 11-deoxycorticosterone (11-DOC) and corticosterone were quantitated in subcellular fractions isolated from in vivo adrenocorticotropin (ACTH)-stimulated rat adrenal zona fasciculata/reticularis. Six adrenal su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e258b0be06227bde1716f2e7ef90e1
https://doi.org/10.1016/0039-128x(85)90050-9
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10
Response of adrenal tumor cells to adrenocorticotropin: site of inhibition by cytochalasin B
Autor: James J. Mrotek, Peter F. Hall
Publikováno v: Biochemistry. 16:3177-3181
The ability of cytochalasin B to inhibit the steroidogenic response of mouse adrenal tumor cells (Y-1) to adrenocorticotropin (ACTH) was examined with two aims: to consider the specificity of the inhibitor and to determine at what point(s) in the ste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64584501cc5e1c5784b1d0486371854a
https://doi.org/10.1021/bi00633a021
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