Zobrazeno 1 - 10
of 21
pro vyhledávání: '"James J. Ludtke"'
Publikováno v:
Molecular Immunology. 45:1501-1513
Natural IgM antibodies (Abs) play an important role in clearing pathogens, enhancing immune responses, and preventing autoimmunity. However, the molecular mechanisms that mediate the functions of natural IgM Abs are understood only to a limited degre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fef2d753a8a94bb1ee01b8c03449ba
https://doi.org/10.1016/j.molimm.2007.07.043
https://doi.org/10.1016/j.molimm.2007.07.043
Autor:
Jason Klein, Darren H. Wakefield, and Alex V. Sokoloff, Sean D. Monahan, Jon A. Wolff, David B. Rozema, Lori Higgs, James J. Ludtke, David L. Lewis, So C. Wong
Publikováno v:
Molecular Pharmaceutics. 3:386-397
A critical step for liver-directed gene therapy is the selective targeting of nucleic acids to hepatocytes. We have previously discovered that the proximal half of the T7 phage tail fiber protein (p17) targeted intact T7 phage and recombinant protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98eda459ef51a3ee01e2580ebf63745a
https://doi.org/10.1021/mp050108r
https://doi.org/10.1021/mp050108r
Publikováno v:
Immunology. 112:237-249
Both the timely clearance of degraded endogenous structures and the presence of secreted natural immunoglobulin M (IgM) are needed to avoid autoimmunity. These requirements may be causally related provided that natural IgM preferentially reacts with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7087459d9fe0527bfcc0114d767b1663
https://doi.org/10.1111/j.1365-2567.2004.01868.x
https://doi.org/10.1111/j.1365-2567.2004.01868.x
Autor:
Guofeng Zhang, Vladimir M. Subbotin, Tatyana Budker, Jon A. Wolff, Magdolna G. Sebestyén, Yoshihiro Sumita, Alex V. Sokoloff, Marcus A. Bachhuber, James J. Ludtke, So C. Wong
Publikováno v:
Molecular Therapy. 8(6):867-872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473f4c5375fbc134f94c77e7150aceb3
Specific Recognition of Protein Carboxy-Terminal Sequences by Natural IgM Antibodies in Normal Serum
Autor:
Anne M. Cooke, Sara Hoffman, Ildiko Bock, Guofeng Zhang, James Dama, James J. Ludtke, Alex V. Sokoloff, Jon A. Wolff
Publikováno v:
Molecular Therapy. 3:821-830
Our previous study indicated that normal serum contains complement-fixing natural IgM antibodies reacting with a large variety of randomly generated protein carboxy-termini. Here we show that the "carboxy-terminal" IgM (C-IgM) antibodies specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb88bbe64775a47e739fbb9cf44cde1
https://doi.org/10.1006/mthe.2001.0340
https://doi.org/10.1006/mthe.2001.0340
Autor:
Vladimir G. Budker, Jeffery D. Fritz, Jon A. Wolff, James E. Hagstrom, Magdolna G. Sebestyén, James J. Ludtke
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1284(1):47-55
Transfection competent complexes were assembled using a three component system. The constituents of the basic system were plasmid DNA, cationic DNA binding protein (NLS-H1) and anionic liposomes (dioleoyl phosphatidylethanolamine (DOPE) or phosphatid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16db9756bf826cf07ed621f21786d98a
Autor:
Martin E. Dowty, Shoushu Jiao, Jon A. Wolff, Randi K. Berg, David B. Slautterback, James J. Ludtke, Phillip Williams, Gabriella Repetto
Publikováno v:
Journal of Cell Science. 103:1249-1259
Plasmid DNA or artificial mRNA injected intramuscularly into skeletal muscle via a 27 g needle expressed transgenes at relatively efficient levels in skeletal myofibers and cardiac cells. In the present study, several approaches were used to determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15a0b3e974606b2364fd77129fd5879
https://doi.org/10.1242/jcs.103.4.1249
https://doi.org/10.1242/jcs.103.4.1249
Publikováno v:
Human Molecular Genetics. 1:363-369
Plasmid pRSVL persisted and expressed luciferase for at least 19 months in mouse skeletal muscle after intramuscular injection. Other injected plasmids also stably expressed long-term suggesting that any plasmid DNA could stably persist and express i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112e72089dd9b195af604de028df81ad
https://doi.org/10.1093/hmg/1.6.363
https://doi.org/10.1093/hmg/1.6.363
Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)
Autor:
Dudley K. Strickland, Guofeng Zhang, So Wong, Jon A. Wolff, Alex V. Sokoloff, James J. Ludtke
Publikováno v:
Drug delivery. 16(5)
It has previously been reported that a peptide sequence of T7 phage protein p17 mediates uptake of its cargo by liver parenchymal cells. The aim of this study was to identify the phage-binding receptor. The involvement of LRP was confirmed by the obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059618fa16f2b79d008d50537608d0c0
https://pubmed.ncbi.nlm.nih.gov/19538008
https://pubmed.ncbi.nlm.nih.gov/19538008
Publikováno v:
Drug delivery. 14(6)
In vivo phage display is a powerful source of new peptide ligands for specific organ targeting by drugs and gene therapy vectors. Since the introduction of this methodology a decade ago, a number of peptides that preferentially react with organ-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8be9137e91307d10d7a7faf19fea50
https://pubmed.ncbi.nlm.nih.gov/17701525
https://pubmed.ncbi.nlm.nih.gov/17701525