Zobrazeno 1 - 10
of 69
pro vyhledávání: '"James J. L. Hodge"'
Publikováno v:
Clocks & Sleep, Vol 5, Iss 3, Pp 499-506 (2023)
Standardization plays a crucial role in ensuring the reliability, reproducibility, and interoperability of research data in the biomedical sciences. Metadata standards are one foundation for the FAIR (Findable, Accessible, Interoperable, and Reusable
Externí odkaz:
https://doaj.org/article/60a684a028224640a464538cffeb239e
Autor:
Amina Aboufares El Alaoui, Edgar Buhl, Sabrina Galizia, James J. L. Hodge, Luisa de Vivo, Michele Bellesi
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Prolonged cellular activity may overload cell function, leading to high rates of protein synthesis and accumulation of misfolded or unassembled proteins, which cause endoplasmic reticulum (ER) stress and activate the unfolded prot
Externí odkaz:
https://doaj.org/article/3e57547dfbcf4ac993fb19b4ab38e84b
Autor:
Bangfu Zhu, Tom Parsons, Christopher Foley, Yeng Shaw, Travis Dunckley, Christopher Hulme, James J. L. Hodge
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Alzheimer’s disease (AD) involves pathological processing of amyloid precursor protein (APP) into amyloid-β and microtubule associated protein Tau (MAPT) into hyperphosphorylated Tau tangles leading to neurodegeneration. Only 5% of AD cas
Externí odkaz:
https://doaj.org/article/423c5c327b354518a7f745c5c9e8f33b
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Schizophrenia shows high heritability and several of the genes associated with this disorder are involved in calcium (Ca2+) signalling and synaptic function. One of these is the Rab-3 interacting molecule-1 (RIM1), which has recently been as
Externí odkaz:
https://doaj.org/article/1af099f96e13459aa3b9218ed9677ef6
Autor:
Bangfu Zhu, Tom Parsons, Wenche Stensen, John S. Mjøen Svendsen, Anders Fugelli, James J. L. Hodge
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Alzheimer’s disease (AD) is the most common neurodegenerative disease which is becoming increasingly prevalent due to ageing populations resulting in huge social, economic, and health costs to the community. Despite the pathological processing of g
Externí odkaz:
https://doaj.org/article/ef83e297b25c4058a94e4f8340a74a31
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists. Memory, circadian rhythmicity and sleep are essent
Externí odkaz:
https://doaj.org/article/cddb73eff2564c4b9fb52c8cbfc10153
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Insects are ectothermal animals that are constrained in their survival and reproduction by external temperature fluctuations which require either active avoidance of or movement towards a given heat source. In Drosophila, different thermorec
Externí odkaz:
https://doaj.org/article/0aaea794aeb948d5b26e08e59be028b0
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Neonicotinoids are the most widely used insecticides in the world and are implicated in the widespread population declines of insects including pollinators. Neonicotinoids target nicotinic acetylcholine receptors which are expressed throughout the in
Externí odkaz:
https://doaj.org/article/5ff67daa7d794ea1a023a5aa3f058dbc
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 705-716 (2017)
Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear. Here, we establish a Drosophila
Externí odkaz:
https://doaj.org/article/9a9fe22a3a9245269c637c9cc24628c2
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The cellular underpinnings of memory deficits in Alzheimer’s disease (AD) are poorly understood. We utilized the tractable neural circuits sub-serving memory in Drosophila to investigate the role of impaired Ca2+ handling in memory deficits caused
Externí odkaz:
https://doaj.org/article/66db0f95a6344ca9b7754c3e27d9ee18