Zobrazeno 1 - 10
of 19
pro vyhledávání: '"James J. Kowalczyk"'
Publikováno v:
Synthesis. 2011:3859-3865
Autor:
Ana Maria Garcia, Hiroshi Ishihara, Masayuki Namiki, Takeshi Nagasu, Katsuji Nakamura, James J. Kowalczyk, Kentaro Yoshimatsu, Atsumi Yamaguchi, Michael D. Lewis
Publikováno v:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 12:477-484
Inhibitors of ras farnesylation have been extensively studied in the preclinical stage, and some of them are being developed in the clinic. Herein, we describe the antitumor activity of a new farnesyl transferase inhibitor, ER-51785. In vitro, ER-517
Publikováno v:
Journal of Biological Chemistry. 272:14093-14097
It has recently been reported that Ki-Ras protein can be modified in vitro by farnesylation or geranylgeranylation. However, a previous analysis of Ki-Ras prenylation in vivo found only farnesylated Ki-Ras. In this report it is shown that under norma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:3073-3078
Compounds in which cysteine of the tetrapeptide CVFM has been replaced with a phenolic benzyl substituent inhibit farnesylation of H-ras protein by farnesyl transferase (FTase). In the most potent inhibitors (e.g., 5-chloro-2-hydroxybenzyl-VFM, IC 50
Publikováno v:
ChemInform. 43
A synthesis of enantiopure cysteine-derived phosphonium reagent (IV), amenable to the kg scale, is developed and its utilization in Wittig reactions is demonstrated.
Autor:
James J. Kowalczyk, Ana Maria Garcia, Michael D. Lewis, Sharon L. Pinnow, Edmund M. Harrington, Karen Ackermann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2775-2780
Compounds in which cysteine and methionine have been linked by amino acids replacing the A1A2 portion of the CA1A2X box template inhibit farnesyl and geranylgeranyl transferases. The expected specificity for FTase over GGTase I is observed. A variety
Publikováno v:
Journal of Biological Chemistry. 268:18415-18418
The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, the first of which, farnesylation, is crucial for t
Autor:
Junke Liu, Francis G. Fang, Silvio Campagna, Edward M. Suh, Veronique Marceau, Ye Yao, James J. Kowalczyk, Shawn Schiller, Hongsheng Cheng, Galina Kuznetsov, Karen TenDyke, Bruce A. Littlefield, Hu Yang, Murray J. Towle, Christina J. Shaffer, Mark Spyvee, Joanne Marsh, Boris M. Seletsky
Publikováno v:
Molecular cancer therapeutics. 8(10)
E7974 is a synthetic analogue of the marine sponge natural product hemiasterlin. Here, we show that E7974, such as parental hemiasterlin, acts via a tubulin-based antimitotic mechanism. E7974 inhibits polymerization of purified tubulin in vitro with
Publikováno v:
Chemische Berichte. 124:729-742
Reactions of [(η5-C5H5)Re(NO)(PPh3)(ClC6H5)]+BF−4 and (n = 5, a; 6, b; 7, c; 8, d) give cycloalkene complexes (6a – d, 94 to 79%). A crystal structure of the methylcyclopentadienyl analog of 6a shows the Re – plane and Re – PPh3 bond to be c
Publikováno v:
Organometallics. 10:1079-1088
Reactions of [(η 5 -C 5 H 5 )Re(NO)(PPh 3 )(ClC 6 H 5 )] + BF 4 − and RC≡CR' (R=R'=H (a), CH 3 (b), CH 2 CH 3 (c), C 6 H 5 (d); R/R'=C(CH 3 ) 3 /H (e)) give alkyne complexes [(η 5 -C 5 H 5 )Re(NO)(PPh 3 )(RC≡CR')] + BF 4 − (4a-e). Crystal s