Zobrazeno 1 - 10
of 39
pro vyhledávání: '"James J. Knox"'
Autor:
Sita Awasthi, Lauren M. Hook, Angela Desmond, Brian T. Gaudette, Gary H. Cohen, Alexis Naughton, Eline T. Luning Prak, Norbert Pardi, Drew Weissman, Harvey M. Friedman, Kevin P. Egan, Michael P. Cancro, David Allman, Mohamad-Gabriel Alameh, James J. Knox, Ying K. Tam, John M. Lubinski
Publikováno v:
J Clin Invest
Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic, latent genital infection rather than an acute respiratory infection. We used animal models to compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a741fabec8cff3ddd90317a5f4694c
https://pubmed.ncbi.nlm.nih.gov/34618692
https://pubmed.ncbi.nlm.nih.gov/34618692
Autor:
Sarah Pyfrom, James J. Knox, Bam Paneru, Jane H. Buckner, Michael P. Cancro, Montserrat C. Anguera, Sylvia Posso
Publikováno v:
Proc Natl Acad Sci U S A
Systemic lupus erythematous (SLE) is a female-predominant disease characterized by autoimmune B cells and pathogenic autoantibody production. Individuals with two or more X chromosomes are at increased risk for SLE, suggesting that X-linked genes con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804e4b4166831fa41ed675019b6a3efb
https://pubmed.ncbi.nlm.nih.gov/34103397
https://pubmed.ncbi.nlm.nih.gov/34103397
Publikováno v:
Immunological Reviews. 288:149-160
B cells expressing the transcription factor T-bet have emerged as participants in a number of protective and pathogenic immune responses. T-bet+ B cells characteristically differentiate in response to combined Toll-like receptor and cytokine signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8e3c46ce1fcea077075a9d54190856
https://doi.org/10.1111/imr.12736
https://doi.org/10.1111/imr.12736
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as key drivers of immune cell development and cytolytic function. While the majority of studies have defined the roles of these factors in the context of murine T-c
Externí odkaz:
https://doaj.org/article/eebed08a062245da89866c59ad968934
Autor:
Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Sonia Ndeupen, Chutamath Sittplangkoon, Joel R. Wilmore, Brian T. Gaudette, Ousamah Y. Soliman, Matthew Pine, Philip Hicks, Tomaz B. Manzoni, James J. Knox, John L. Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M. Rosenfeld, Shirin Strohmeier, Paulo J.C. Lin, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P. Cancro, Drew Weissman, Eline T. Luning Prak, David Allman, Botond Z. Igyártó, Michela Locci, Norbert Pardi
Publikováno v:
Immunity
Adjuvants are critical for improving the quality and magnitude of adaptive immune responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against SARS-CoV-2, but the mechanism of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4d90aa5a85f3e9356bf076e36d8f31
https://pubmed.ncbi.nlm.nih.gov/35704995
https://pubmed.ncbi.nlm.nih.gov/35704995
Autor:
Jeongho Park, Jonathan H. DeLong, Elia D. Tait Wojno, Christoph Konradt, James J. Knox, Christopher A. Hunter
Publikováno v:
Infect Immun
Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the subunits IL-27p28 and EBi3, and while the IL-27 heterodimer influences T cell activities, there is evidence that IL-27p28 can have EBi3-independent activities; however, their relevanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c42edb83692be974af7c02b371f32d
https://doi.org/10.1128/iai.00455-19
https://doi.org/10.1128/iai.00455-19
Autor:
Wenzhao Meng, Daniela Weiskopf, Michael R. Betts, Xiaoming Xu, James J. Knox, Kyabeth Toress-Rodriguez, Noelle V. Frey, Wei-Ting Hwang, Alfred L. Garfall, Ali Naji, Eline Luning-Prak, Vijay Bhoj, Carl H. June, Kalpana Parvathaneni, David L. Porter
Publikováno v:
Blood. 138:1757-1757
Abstract Background: The two FDA approved mRNA-based SARS-CoV2 vaccines have shown >90% efficacy at preventing COVID and eliciting protective immunity in nearly all healthy individuals. However, the extent of vaccine induced antibody and T cell immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abbf333debfcd453471507e027afe9b7
https://doi.org/10.1182/blood-2021-153730
https://doi.org/10.1182/blood-2021-153730
Publikováno v:
Cellular Immunology. 321:26-34
T-bet-expressing B cells, first identified as perpetuators of autoimmunity, were recently shown to be critical for murine antiviral responses. While their role in human viral infections remains unclear, B cells expressing T-bet or demonstrating a rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749332bfcd945c33e092c25b3f19603f
https://doi.org/10.1016/j.cellimm.2017.04.012
https://doi.org/10.1016/j.cellimm.2017.04.012
Autor:
Lan Ngyuen, Erin H. Graf, James J. Knox, Kiana Roman, Sandra Montgomery, Andrew P. Tomaras, Ana María Cárdenas
Publikováno v:
Journal of Clinical Microbiology. 55:1802-1811
Urinary tract infections are one of the most common reasons for health care visits. Diagnosis and optimal treatment often require a urine culture, which takes an average of 1.5 to 2 days from urine collection to results, delaying optimal therapy. Fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e72c037f41386da31e60f5e9bcc8284
https://doi.org/10.1128/jcm.00027-17
https://doi.org/10.1128/jcm.00027-17
Autor:
Rebecca L. Rosenthal, Jonathan W. Yewdell, Mariya Kostiv, E. John Wherry, Michael R. Betts, John L. Johnson, James J. Knox, Ali Naji, Shannon R. Christensen, Norbert Pardi, Joanna Madej, Michael P. Cancro, Max Itkin, Drew Weissman, Wenzhao Meng, Jinfang Zhu, Arpita Myles, Yoav Dori, Eline T. Luning Prak, Aaron M. Rosenfeld, Adrian B. McDermott, David H. Canaday, Scott E. Hensley, Martin S. Naradikian
Publikováno v:
Immunity
B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here we examined the anatomic distribution, clonal relationships, and functional properties of T-bet(+) and T-bet(−) memory B ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd51f6adbe3da1d04da02d21d20be79a
https://doi.org/10.1016/j.immuni.2020.03.020
https://doi.org/10.1016/j.immuni.2020.03.020