Zobrazeno 1 - 10
of 101
pro vyhledávání: '"James J. Kaminski"'
Publikováno v:
International Journal of Quantum Chemistry. 36:291-300
The {triangle}{sup 3} double bond of cephalosporins isomerizes to the {triangle}{sup 2} position, resulting in biological inactivation of these antibiotics. This phenomenon occurs slowly in the case of cephalosporanic acids, but is rapid when the 4-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c0c1399f48ae15c9eb2361a22dcd805
https://doi.org/10.1002/qua.560360723
https://doi.org/10.1002/qua.560360723
Autor:
Dennis V. Nazareno, Guowei Zhou, Herbert Binch, William J. Greenlee, Mary Cohen-Williams, Jayaram R. Tagat, Diane E. Grotz, Jean E. Lachowicz, James J. Kaminski, Joseph A. Kozlowski, Gordon Crosby, Stuart W. McCombie, Vicki L. Coffin, Kathleen Cox, Vilma Ruperto, Craig D. Boyle, Samuel Chackalamannil, Ruth A. Duffy, Hubert B. Josien, Yuguang Wang, John W. Clader, William Billard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2311-2314
The potential toxicological liabilities of the M(2) muscarinic antagonist 1 were addressed by replacing the methylenedioxyphenyl moiety with a p-methoxyphenyl group, resulting in M(2) selective compounds such as 3. Several halogenated naphthamide der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4596ee0f6758218aaf4305ca38b8523f
https://doi.org/10.1016/s0960-894x(01)00435-8
https://doi.org/10.1016/s0960-894x(01)00435-8
Autor:
Michael Czarniecki, Pradip R. Das, Max Kugelman, Dinesh Gala, James J. Kaminski, Mohindar S. Puar
Publikováno v:
Tetrahedron Letters. 41:5025-5029
First base induced opening of multicyclic guanines to isolable substituted imidazoles, and possible mechanism for this observation are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dbbfdcb13cb6d2e1d1770f0ef1a8223
https://doi.org/10.1016/s0040-4039(00)00770-x
https://doi.org/10.1016/s0040-4039(00)00770-x
Autor:
Alan K. Mallams, Doll Ronald J, Shiyong Wang, Jesse Wong, Walter R. Bishop, Ashit K. Ganguly, F. G. Njoroge, Donna Carr, Linda James, Bancha Vibulbhan, Taveras Arthur G, Z. Li, C. Nardo, I. King, James J. Kaminski, Joanne M. Petrin, Paul Kirschmeier, V. Girijavallabhan, Stacy W. Remiszewski, Ming Liu, Carmen S. Alvarez, Randall R. Rossman, Chin-Chung Lin, Mathew S. Bryant, Mark E. Snow, Joseph J. Catino
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:93-99
Ras farnesylation by farnesyl protein transferase (FPT) is an intracellular event that facilitates the membrane association of the ras protein and is involved in the signal transduction process. FPT inhibition could be a novel, noncytotoxic method of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdd49eb71b5afed18bb647abc8d9d3f
https://doi.org/10.1016/s0968-0896(96)00205-2
https://doi.org/10.1016/s0968-0896(96)00205-2
Publikováno v:
Expert Opinion on Investigational Drugs. 4:1021-1025
Investigational drugs that either inhibit the metabolism of arachidonic acid to prostaglandins and leukotrienes, or antagonise leukotriene receptors, continue to be evaluated clinically. The encouraging clinical results observed with these agents pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22cf5fd5de11f9f5944f78a3190af8e
https://doi.org/10.1517/13543784.4.10.1021
https://doi.org/10.1517/13543784.4.10.1021
Publikováno v:
Expert Opinion on Therapeutic Patents. 4:957-968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c5d48c4245a1e767de878e6c449213f
https://doi.org/10.1517/13543776.4.8.957
https://doi.org/10.1517/13543776.4.8.957
Autor:
James J. Kaminski
Publikováno v:
Advanced Drug Delivery Reviews. 14:331-337
Comparative molecular field analysis ( CoMFA ), a promising new statistical and graphic three-dimensional quantitative structure-activity relationship (3D-QSAR) technique, and its potential in the drug discovery and design process are reviewed. CoMFA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a115329aae2114ed4a2e01033493da
https://doi.org/10.1016/0169-409x(94)90049-3
https://doi.org/10.1016/0169-409x(94)90049-3
Publikováno v:
Current Opinion on Therapeutic Patents. 3:1629-1640
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3d4d70534a63dc4e58ca3a156a4045c
https://doi.org/10.1517/13543776.3.11.1629
https://doi.org/10.1517/13543776.3.11.1629
Publikováno v:
Current Opinion on Therapeutic Patents. 3:749-766
(1993). Patent Update: Potential Therapeutics for the Treatment of Allergic and Gastrointestinal Disorders: Patent Activity July to December 1992. Current Opinion on Therapeutic Patents: Vol. 3, No. 6, pp. 749-766.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99c4ab8ae4250c1e4e91a957b1306b0
https://doi.org/10.1517/13543776.3.6.749
https://doi.org/10.1517/13543776.3.6.749
Autor:
Marcus E. Brewster, James J. Kaminski, Josef Pitha, Michael J. S. Dewar, Nicholas Bodor, Emil Pop, Ming-Ju Huang
Publikováno v:
Carbohydrate Research. 242:53-67
Chemical reactivity and other characteristics of α- d -glucopyranose and β-maltose were evaluated within a semiempirical molecular orbital (AM1) framework. Theoretically generated structures compared well to those determined by X-ray crystallograph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5bca78da77bf81d489e6f65a7d87bc
https://doi.org/10.1016/0008-6215(93)80021-6
https://doi.org/10.1016/0008-6215(93)80021-6