Zobrazeno 1 - 10
of 38
pro vyhledávání: '"James J. Hartman"'
Autor:
Guanyi Huang, Anjali Bisaria, Devin L. Wakefield, Tracy M. Yamawaki, Xin Luo, Jingli A. Zhang, Patrick Vigneault, Jinghong Wang, Jeffrey D. Reagan, Oliver Oliverio, Hong Zhou, Chi-Ming Li, Olaia F. Vila, Songli Wang, Fady I. Malik, James J. Hartman, Christopher M. Hale
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 220-236 (2023)
Summary: Titin-truncating variants (TTNtv) are the single largest genetic cause of dilated cardiomyopathy (DCM). In this study we modeled disease phenotypes of A-band TTNtv-induced DCM in human induced pluripotent stem cell-derived cardiomyocytes (hi
Externí odkaz:
https://doaj.org/article/30e3b255f0a347979433bbc120f0b28e
Autor:
Vicente J. Planelles-Herrero, James J. Hartman, Julien Robert-Paganin, Fady I. Malik, Anne Houdusse
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Omecamtiv mecarbil (OM) is a cardiac myosin activator that is currently in clinical trials for heart failure treatment. Here, the authors give insights into its mode of action and present the crystal structure of OM bound to bovine cardiac myosin, wh
Externí odkaz:
https://doaj.org/article/e89f50badcf146dca49a24d78e0e1fa7
Autor:
David W Hammers, Melissa Merscham‐Banda, Jennifer Ying Hsiao, Stefan Engst, James J Hartman, H Lee Sweeney
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 4, Pp 531-544 (2017)
Abstract Growth and differentiation factor (GDF) 11 is a member of the transforming growth factor β superfamily recently identified as a potential therapeutic for age‐related cardiac and skeletal muscle decrements, despite high homology to myostat
Externí odkaz:
https://doaj.org/article/67dae0850aad4379b5c9b3b9067508ee
Autor:
Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14930-14941
The discovery of reldesemtiv, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit 1 led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68
https://doi.org/10.1021/acs.jmedchem.1c01067
https://doi.org/10.1021/acs.jmedchem.1c01067
Autor:
Laura A. Robertson, Julia Schaletzky, Xiaolin Wang, Chihyuan Chuang, Yangsong Wu, James J. Hartman, Jingying Wang, Eddie Wehri, Eva R. Chin, Fady I. Malik, Scott Collibee, Mark Vander Wal, Jeanelle Zamora, Peadar Cremin, Morgan Bradley P, Luke W. Ashcraft, Darren T. Hwee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14142-14152
Hypercontractility of the cardiac sarcomere may be essential for the underlying pathological hypertrophy and fibrosis in genetic hypertrophic cardiomyopathies. Aficamten (CK-274) is a novel cardiac myosin inhibitor that was discovered from the optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57e158c743a4bf8ac97172694a8e35d
https://doi.org/10.1021/acs.jmedchem.1c01290
https://doi.org/10.1021/acs.jmedchem.1c01290
Publikováno v:
Journal of Medicinal Chemistry. 64:3026-3034
Troponin regulates the calcium-mediated activation of skeletal muscle. Muscle weakness in diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy occurs from diminished neuromuscular output. The first direct fast skeletal troponin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10f0c1b003ab1eedfedbd57ded89092
https://doi.org/10.1021/acs.jmedchem.0c01412
https://doi.org/10.1021/acs.jmedchem.0c01412
Autor:
Saswata Sankar Sarkar, James J. Hartman, Darren T. Hwee, Chihyuan Chuang, Peadar Cremin, Andre deRosier, Samantha Edell, Roshni Madhvani, Yangsong Wu, Lisette Yco, Jeanelle Zamora, Anne Murphy, Bradley P. Morgan, Fady I. Malik
Publikováno v:
Biophysical Journal. 122:122a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b49ab7795d43ec7ed50966524b63713
https://doi.org/10.1016/j.bpj.2022.11.828
https://doi.org/10.1016/j.bpj.2022.11.828
Autor:
Rohit R. Singh, Rebecca E. Slater, Jinghong Wang, Chen Wang, Qi Guo, Alykhan S. Motani, James J. Hartman, Sakthivel Sadayappan, Brandon L. Ason
Publikováno v:
JACC. Basic to translational science. 7(10)
Modulation of sarcomere contractility represents a new therapeutic opportunity for the treatment of heart failure by directly targeting the thick and thin filament proteins of the sarcomere to increase cardiac muscle contraction. This study compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a61574694c217eacf0dd6691801b24
https://pubmed.ncbi.nlm.nih.gov/36337919
https://pubmed.ncbi.nlm.nih.gov/36337919
Publikováno v:
Journal of medicinal chemistry. 64(6)
Troponin regulates the calcium-mediated activation of skeletal muscle. Muscle weakness in diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy occurs from diminished neuromuscular output. The first direct fast skeletal troponin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35aae367ddc6852e7b36d1d8ef9f5d8f
https://pubmed.ncbi.nlm.nih.gov/33703886
https://pubmed.ncbi.nlm.nih.gov/33703886
Autor:
Jingying Wang, James J. Hartman, Yangsong Wu, Xihui Xu, Fady I. Malik, Darren T. Hwee, Bradley P Morgan, Eva R. Chin, Claire McHugh
Publikováno v:
Circulation. 142
Introduction: Heart failure with preserved ejection fraction (HFpEF) is characterized by underlying contractile dysfunction and progressive myocardial fibrosis and stiffness. CK-3772271 (CK-271) is a novel small molecule cardiac myosin inhibitor that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3a85d424eb12904f5e594b69687d75
https://doi.org/10.1161/circ.142.suppl_3.14390
https://doi.org/10.1161/circ.142.suppl_3.14390