Výsledky vyhledávání - "James J. Gormley"

Nutritional Supplements Modulating Metabolic Syndrome Risk Factors and the Prevention of Cardiovascular Disease

Publikováno v: Current Nutrition & Food Science. 1:1-11

Metabolic syndrome risk factors (MSRF) can lead to cardiovascula r disease (CVD) and its prevalence is increasing at an alarming rate in the United States and worldwide. Pathways leading directly from visceral adiposity to the genesis of free fatty a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e8cc09db9275d4db4d33ff43499f835
https://doi.org/10.2174/1573401052953249

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Potent Cyclic Monomeric and Dimeric Peptide Inhibitors of VLA-4 (?4?1 Integrin)-Mediated Cell Adhesion Based on the Ile-Leu-Asp-Val Tetrapeptide

Autor: Anand S. Dutta, Amanda Rees, Alec Jamieson, Duncan Haworth, Rod S. Kittlety, Lorraine A. Hassall, Paul Gellert, James J. Gormley, Christopher F. Reilly, Peter J. Alcock, Christopher F. Hayward, Linda J. Wood, Mandy L. Crowther, Julie M. Moores

Publikováno v: Journal of Peptide Science. 6:321-341

Potent monomeric and dimeric cyclic peptide very late antigen-4 (VLA-4) inhibitors have been designed based on a tetrapeptide (Ile-Leu-Asp-Val) sequence present in a 25-amino acid peptide (CS-1) reported in the literature. The peptides, synthesized b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25ceb93494fef4de3a60f6b947f394cc
https://doi.org/10.1002/1099-1387(200007)6:7<321::aid-psc259>3.0.co

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Potent cyclic peptide inhibitors of VLA-4 (?4?1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-d-Arg-d-Arg) (ZD7349) compatible with depot formulation

Autor: Paul Gellert, Peter J. Alcock, Duncan Haworth, Anand S. Dutta, Tracy Halterman, Roger Ferguson, Linda J. Wood, Julie M. Moores, Lorraine A. Hassall, Christopher F. Hayward, James J. Gormley, Christopher F. Reilly, Matthew M Coath, Jackie Moors, Amanda Rees, Rod S. Kittlety, Alec Jamieson

Publikováno v: Journal of Peptide Science. 6:398-412

Additional structure–activity relationship studies on potent cyclic peptide inhibitors of very late antigen-4 (VLA-4) are reported. The new N- to C-terminal cyclic hexa-, hepta- and octapeptide inhibitors like cyclo(MeIle/MePhe-Leu-Asp-Val-X) (X=2�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76652a961e3b5a12e5486a93642eb39f
https://doi.org/10.1002/1099-1387(200008)6:8<398::aid-psc270>3.0.co

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Anti-inflammatory activity of c(ILDV-NH(CH2)5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion

Autor: Peter J. Alcock, Amanda Rees, Anand S. Dutta, Alec Jamieson, Christopher F. Reilly, Duncan Haworth, Huw B Jones, Linda J. Wood, James J. Gormley

Publikováno v: British Journal of Pharmacology. 126:1751-1760

1. Small, N- to C-terminal cyclized peptides containing the leucyl-aspartyl-valine (LDV) motif from fibronectin connecting segment-1 (CS-1) have been investigated for their effects on the adhesion of human T-lymphoblastic leukaemia cells (MOLT-4) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8964fddd9cfecc984eabca246c2f17c6
https://doi.org/10.1038/sj.bjp.0702511

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Bioactive Nutrients and Cardiovascular Disease

Autor: James J. Gormley, Vijaya Juturu

Coronary heart disease (CHD) accounts for the majority of cardiovascular disease (CVD) deaths in men and women. Abnormal function of the heart and blood vessels increases the risk for heart attack, heart failure, sudden death, stroke, and cardiac rhy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d717f4a434697665c8739b637152a32
https://doi.org/10.1016/b978-0-12-396485-4.00003-7

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Partially Hydrogenated Fats in the US Diet and Their Role in Disease

Autor: Vijaya Juturu, James J. Gormley

Publikováno v: Modern Dietary Fat Intakes in Disease Promotion ISBN: 9781603275705

• To formulators, hydrogenated vegetable oils provide distinctive flavor, crispness, creaminess, plasticity, and oxidation stability. Refinement of the industrial technology of partial hydrogenation and appropriate food labeling may lead to a consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b14938e903af9d2d540ace372f84dc86
https://doi.org/10.1007/978-1-60327-571-2_5

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Fatty Acids, Insulin Resistance and Diabetes

Autor: Vijaya Juturu, James J. Gormley

Publikováno v: Wild-Type Food in Health Promotion and Disease Prevention ISBN: 9781588296689

Recent data strongly suggest that atherosclerosis progression may be slowed by increased intakes of essential fatty acids (EFAs) from fish even in diabetes. The current evidence also indicates the potential benefits of EFAs on atrial fibrillation, pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcc5af7eab060eb9e30836463e4d69b0
https://doi.org/10.1007/978-1-59745-330-1_18

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Inhibitors of human renin. Cyclic peptide analogs containing a D-Phe-Lys-D-Trp sequence

Autor: Peter F. McLachlan, J. S. Major, Anand S. Dutta, James J. Gormley

Publikováno v: Journal of Medicinal Chemistry. 33:2560-2568

Cyclic peptides containing a D-phenylalanine and a D-tryptophan residue have been synthesized and tested as inhibitors of human renin. Most of these are tripeptide derivatives of the type CO(CH2)3CO-D-Phe-Lys-D-Trp- or COCH2NHCH2CO-D-Phe-Lys-D-Trp- i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d6d7c41cba8b5828fa608b0bbfa663
https://doi.org/10.1021/jm00171a034

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