Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James J. DeVoss"'
Autor:
Allan E. Rettie, Leslie J. Dickmann, Elizabeth M. J. Gillam, Nicholas J. Matovic, Guoying Tai, James J. DeVoss
Publikováno v:
Drug Metabolism and Disposition. 36:1992-1997
A common feature of many CYP2C9 ligands is their weak acidity. As revealed by crystallography, the structural basis for this behavior involves a charge-pairing interaction between an anionic moiety on the substrate and an active site R108 residue. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd17dd47127fda7e70793bdbb4d438a
https://doi.org/10.1124/dmd.108.022186
https://doi.org/10.1124/dmd.108.022186
Publikováno v:
Gene. 395:40-48
The cytochrome P450 enzymes involved in xenobiotic metabolism are an excellent starting point for the directed evolution of novel biocatalysts due to their wide substrate specificity. A shuffled library of three highly homologous mammalian genes (for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5893fec57a9eec6a3b7be7403420d8
https://doi.org/10.1016/j.gene.2007.01.031
https://doi.org/10.1016/j.gene.2007.01.031
Autor:
Justin R. Scott, Andrew G. Pearson, Katey Witham, Carwyn Davies, Elizabeth M. J. Gillam, Sandra E. Graham, James J. DeVoss
Publikováno v:
Drug Metabolism and Disposition. 32:431-436
CYP2C9 is distinguished by a preference for substrates bearing a negative charge at physiological pH. Previous studies have suggested that CYP2C9 residues R97 and K72 may play roles in determining preference for anionic substrates by interaction at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5379f0d97090cfc7a442370cae83030e
https://doi.org/10.1124/dmd.32.4.431
https://doi.org/10.1124/dmd.32.4.431
Autor:
Jeannette E. Stok, Patricia Y. Hayes, Christopher S. P. McErlean, Sharon Chow, Matthew J. McGrath, Hesheng Zhang, Natasha L. Hungerford, Yong Q. Tu, James J. DeVoss, Christopher J. Moore, Mary T. Fletcher, William Kitching
Publikováno v:
Chirality. 15:S116-S127
Examination of the chemistry of a number of Australian insect species provided examples of unusual structures and encouraged determinations of their absolute stereochemistry by stereocontrolled syntheses and chromatographic comparisons. Inter alia, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a005043570f7678fa22ef2a17eceb437
https://doi.org/10.1002/chir.10273
https://doi.org/10.1002/chir.10273
Publikováno v:
The Journal of Organic Chemistry. 59:6194-6199
In efforts to synthesize haloperidol analogues with improved properties as HIV protease inhibitors, methods were sought to introduce mono- and dialkylamino groups into the two aromatic rings of the parent structure. We report here that the reaction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b391f5da0931eb08d5890c5ecb3df655
https://doi.org/10.1021/jo00100a021
https://doi.org/10.1021/jo00100a021
Autor:
William Kitching, M. G. O'shea, Joanne T. Blanchfield, Joanne F. Jamie, Mary T. Fletcher, James J. DeVoss
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07b01188c5db88cfa9060488091dfdc5
https://doi.org/10.1002/chin.199124150
https://doi.org/10.1002/chin.199124150
Autor:
B. E. Mazomenos, M. A. Konstantopoulou, F. D. Krokos, A. Huebener, William Kitching, Natasha L. Hungerford, Christopher J Moore, Mary T. Fletcher, James J. DeVoss, George E. Haniotakis
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f84ee332105a0379e87f326bd785631b
https://doi.org/10.1002/chin.199832295
https://doi.org/10.1002/chin.199832295
Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites
Publikováno v:
Chemical research in toxicology. 19(7)
Haloperidol (HP) has been reported to undergo cytochrome P450 (P450)-mediated metabolism to potentially neurotoxic pyridinium metabolites; however, the chemical pathways and specific enzymes involved in these reactions remain to be identified. The ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b844d826fc666042c92db5cbcf474a53
https://pubmed.ncbi.nlm.nih.gov/16841959
https://pubmed.ncbi.nlm.nih.gov/16841959
Autor:
Pavel Soucek, James J. DeVoss, Donghak Kim, L. Notley, Anna Marie A. Aguinaldo, Alexander Volkov, Elizabeth M. J. Gillam, F. Peter Guengerich, Frances H. Arnold, Ralf G. Mundkowski
Publikováno v:
Biochemical and biophysical research communications. 265(2)
The development of bicistronic systems for coexpression of recombinant human cytochrome P450 enzymes (P450s) with their redox partner, NADPH-cytochrome P450 reductase (NPR), has enabled P450 activity to be reconstituted within bacterial cells. During
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e1613ccc66fc715df4c95728396eca
https://pubmed.ncbi.nlm.nih.gov/10558891
https://pubmed.ncbi.nlm.nih.gov/10558891
Autor:
B. E. Mazomenos, William Kitching, F. D. Krokos, Christopher J. Moore, Natasha L. Hungerford, Mary T. Fletcher, James J. DeVoss, George E. Haniotakis, Achim Hübener, M. A. Konstantopoulou
Publikováno v:
Chemical Communications. :863-864
A likely pathway to the sex pheromones of Bactrocera oleae (olive fruit-fly) is presented, based mainly on feeding experiments with deuterium labelled precursors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b30977c33b847ae4d004f4cc0277d646
https://doi.org/10.1039/a800691a
https://doi.org/10.1039/a800691a