Zobrazeno 1 - 10
of 140
pro vyhledávání: '"James J. Cai"'
Autor:
Hernan A. Bazan, Surjyadipta Bhattacharjee, Madigan M. Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey A. St Pierre, Neehar Desai, Patrick W. Daly, Jessica A. Cucinello-Ragland, Scott Edwards, Javier Recio, Julio Alvarez-Builla, James J. Cai, Nicolas G. Bazan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-35 (2024)
Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal damage from chronic non-steroidal anti-inflammatory dru
Externí odkaz:
https://doaj.org/article/e955fc7d7b3b4d97b98770099763f826
Autor:
Irshad Ahmad, Shreyan Gupta, Patricia Faulkner, Destiny Mullens, Micah Thomas, Sharanee P. Sytha, Ivan Ivanov, James J. Cai, Cristine L. Heaps, Annie E. Newell-Fugate
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Coronary artery disease (CAD) is a leading cause of death in women. Epicardial adipose tissue (EAT) secretes cytokines to modulate coronary artery function, and the release of fatty acids from EAT serves as a readily available ene
Externí odkaz:
https://doaj.org/article/0519bec3cfbc427582605dde5718e025
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTCoronaviruses (CoVs), including severe acute respiratory syndrome coronavirus 2, can infect a variety of mammalian and avian hosts with significant medical and economic consequences. During the life cycle of CoV, a coordinated series of subge
Externí odkaz:
https://doaj.org/article/7d6c49328d1b4cb6927f5c75f91be688
Autor:
Cristhian Roman-Vicharra, James J. Cai
Publikováno v:
npj Quantum Information, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract In this work, we present a quantum circuit model for inferring gene regulatory networks (GRNs) from single-cell transcriptomic data. The model employs qubit entanglement to simulate interactions between genes, resulting in competitive perfor
Externí odkaz:
https://doaj.org/article/4d4ab0d98e4641809e99866b8e8cda5d
Autor:
Mayur Doke, Jay P. McLaughlin, James J. Cai, Gurudutt Pendyala, Fatah Kashanchi, Mansoor A. Khan, Thangavel Samikkannu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 243-258 (2022)
Clinical research has proven that HIV-positive (HIV+) individuals with cocaine abuse show behavioral and neurocognitive disorders. Noncoding RNAs (ncRNAs), such as long ncRNAs (lncRNAs) and microRNAs (miRNAs), are known to regulate gene expression in
Externí odkaz:
https://doaj.org/article/99c21f664fe7499993b1865d8ec12f59
Autor:
Jingshu Chen, Shu Tang, Sui Ke, James J. Cai, Daniel Osorio, Andrei Golovko, Benjamin Morpurgo, Shaodong Guo, Yuxiang Sun, Melanie Winkle, George A. Calin, Yanan Tian
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102377- (2022)
The metastasis-associated lung adenocarcinoma transcript1 (MALAT1) is a long noncoding RNA (lncRNA) and is known for its role in cancer development and prognosis. In this study, we report that MALAT1 plays an important role in regulating acute inflam
Externí odkaz:
https://doaj.org/article/34ce029492de4ce592dd5e9326126f50
Autor:
Nan Ni, Xin Fang, Destiny A. Mullens, James J. Cai, Ivan Ivanov, Laurent Bartholin, Qinglei Li
Publikováno v:
Cancers, Vol 14, Iss 9, p 2184 (2022)
Ovarian granulosa cell tumors (GCTs) are rare sex cord-stromal tumors, accounting for ~5% ovarian tumors. The etiology of GCTs remains poorly defined. Genetically engineered mouse models are potentially valuable for understanding the pathogenesis of
Externí odkaz:
https://doaj.org/article/c29402f96b3b4395a8376aa2ea149fe5
Autor:
Qian Xu, Guanxun Li, Daniel Osorio, Yan Zhong, Yongjian Yang, Yu-Te Lin, Xiuren Zhang, James J. Cai
Publikováno v:
Genes, Vol 13, Iss 2, p 371 (2022)
Trajectory inference (TI) or pseudotime analysis has dramatically extended the analytical framework of single-cell RNA-seq data, allowing regulatory genes contributing to cell differentiation and those involved in various dynamic cellular processes t
Externí odkaz:
https://doaj.org/article/3ed64f579c184da8810471addf310ff0
Publikováno v:
BMC Bioinformatics, Vol 19, Iss S3, Pp 35-44 (2018)
Abstract Background Analyzing Variance heterogeneity in genome wide association studies (vGWAS) is an emerging approach for detecting genetic loci involved in gene-gene and gene-environment interactions. vGWAS analysis detects variability in phenotyp
Externí odkaz:
https://doaj.org/article/57cdad4a2290412ba0868993aa92c5d5
Autor:
Susanna K. P. Lau, George C. S. Lo, Franklin W. N. Chow, Rachel Y. Y. Fan, James J. Cai, Kwok-Yung Yuen, Patrick C. Y. Woo
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Talaromyces marneffei is the most important thermal dimorphic fungus causing systemic mycosis in Southeast Asia. We report the discovery of a novel partitivirus, Talaromyces marneffei partitivirus-1 (TmPV1). TmPV1 was detected in 7 (12.7%) o
Externí odkaz:
https://doaj.org/article/20d23f109ec847e3b1ab7cc0c66049f6