Zobrazeno 1 - 10
of 111
pro vyhledávání: '"James J. Bieker"'
Publikováno v:
Frontiers in Hematology, Vol 2 (2024)
IntroductionEKLF/Klf1 is a tissue-restricted transcription factor that plays a critical role in all aspects of erythropoiesis. Of particular note is its tissue-restricted pattern of expression, a property that could prove useful for expression contro
Externí odkaz:
https://doaj.org/article/ab3691a129df458cabf86927def746e6
Autor:
Alisha May, Telma Ventura, Antonella Fidanza, Helena Volmer, Helen Taylor, Nicola Romanò, Sunita L. D’Souza, James J. Bieker, Lesley M. Forrester
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Congenital dyserythropoietic anaemia (CDA) type IV has been associated with an amino acid substitution, Glu325Lys (E325K), in the transcription factor KLF1. These patients present with a range of symptoms, including the persistence of n
Externí odkaz:
https://doaj.org/article/c88b612d1db749ba874de06480b3d793
Autor:
Kaustav Mukherjee, James J. Bieker
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
During definitive erythropoiesis, maturation of erythroid progenitors into enucleated reticulocytes requires the erythroblastic island (EBI) niche comprising a central macrophage attached to differentiating erythroid progenitors. Normally, the macrop
Externí odkaz:
https://doaj.org/article/1b9afa530f5b42edb1bced44db6697bd
Autor:
Vera Alexeeva, Iraz T. Aydin, Christoph Schaniel, Alec W. Stranahan, Sunita L. D'Souza, James J. Bieker
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Hemoglobin production during mammalian development is characterized by temporal switches of the genes coding for the α- and ß-globin chains. Defects in this controlled process can lead to hemoglobinapathies such as sickle cell disease and ß-thalas
Externí odkaz:
https://doaj.org/article/14de96b7f3784057a8b7643c838edbfe
Autor:
Lilian Varricchio, Antanas Planutis, Deepa Manwani, Julie Jaffray, W. Beau Mitchell, Anna Rita Migliaccio, James J. Bieker
Publikováno v:
Haematologica, Vol 104, Iss 12 (2019)
Congenital dyserythropoietic anemia type IV is caused by a heterozygous mutation, Glu325Lys (E325K), in the KLF1 transcription factor. Molecular characteristics of this disease have not been clarified, partly due to its rarity. We expanded erythroid
Externí odkaz:
https://doaj.org/article/e187420825ac46e888bd855ac18854de
Autor:
Kaustav Mukherjee, Li Xue, Antanas Planutis, Merlin Nithya Gnanapragasam, Andrew Chess, James J Bieker
Publikováno v:
eLife, Vol 10 (2021)
Erythroblastic islands are a specialized niche that contain a central macrophage surrounded by erythroid cells at various stages of maturation. However, identifying the precise genetic and transcriptional control mechanisms in the island macrophage r
Externí odkaz:
https://doaj.org/article/114d6be5ad1f4424b421c4eb34c01a2e
Autor:
Lilian Varricchio, Eliza B Geer, Fabrizio Martelli, Maria Mazzarini, Alister Funnell, James J Bieker, Thalia Papayannopoulou, Anna Rita Migliaccio
Publikováno v:
Haematologica. 108:1053-1067
Although human cell cultures stimulated with dexamethasone suggest that the glucocorticoid receptor (GR) activates stress erythropoiesis, the effects of GR activation on erythropoiesis in vivo remain poorly understood. We characterized the phenotype
Autor:
Ivan Ferrer-Vicens, Daniel C. J. Ferguson, Marieangela C Wilson, Kate J Heesom, James J Bieker, Jan Frayne
Publikováno v:
Blood Journal.
Red blood cell disorders can result in severe anemia. One such disease, congenital dyserythropoietic anemia IV (CDA IV) is caused by heterozygous mutation E325K in the transcription factor KLF1. However, studying the molecular basis of CDA IV is seve
Autor:
Tasleem Arif, James J Bieker
Publikováno v:
Blood. 140:1239-1240
Autor:
Lilian, Varricchio, Eliza B, Geer, Fabrizio, Martelli, Maria, Mazzarini, Alister, Funnell, James J, Bieker, Thalia, Papayannopoulou, Anna Rita, Migliaccio
Publikováno v:
Haematologica.
Although human cultures stimulated with dexamethasone suggest that the glucocorticoid receptor (GR) activates stress erythropoiesis, the effects of GR activation on erythropoiesis in vivo remains poorly understood. We characterized the phenotype of a