Zobrazeno 1 - 10
of 59
pro vyhledávání: '"James J Petrik"'
Autor:
David P. Cook, Kristianne J. C. Galpin, Galaxia M. Rodriguez, Noor Shakfa, Juliette Wilson-Sanchez, Maryam Echaibi, Madison Pereira, Kathy Matuszewska, Jacob Haagsma, Humaira Murshed, Alison O. Cudmore, Elizabeth MacDonald, Alicia Tone, Trevor G. Shepherd, James J. Petrik, Madhuri Koti, Barbara C. Vanderhyden
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Ovarian cancers exhibit high rates of recurrence and poor treatment response. Preclinical models that recapitulate human disease are critical to develop new therapeutic approaches. Syngeneic mouse models allow for the generation of tumours c
Externí odkaz:
https://doaj.org/article/f661987fb8f3474ebc28deb27ada3401
Autor:
Lisa A. Santry, Jacob P. van Vloten, Amanda W. K. AuYeung, Robert C. Mould, Jacob G. E. Yates, Thomas M. McAusland, James J. Petrik, Pierre P. Major, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionTumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myel
Externí odkaz:
https://doaj.org/article/0dc2b238fb124dce87ad725117251258
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jake G.E. Yates, Lisa A. Santry, Kathy Matuszewska, Madison Pereira, Melanie M. Goens, Alicia M. Viloria-Petit, Geoffrey A. Wood, Khalil Karimi, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100748- (2023)
Immunotherapies revive host immune responses against tumors by stimulating innate and adaptive immune effector cells with antitumor functions. Thus, detailed studies of immunological cell phenotypes and functions within the tumor microenvironment (TM
Externí odkaz:
https://doaj.org/article/741bb4cb64894b1a844ac39272790cc9
Autor:
Jacob P. van Vloten, Jessica A. Minott, Thomas M. McAusland, Joelle C. Ingrao, Lisa A. Santry, Grant McFadden, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 434-447 (2021)
Poxviruses have been used extensively as vaccine vectors for human and veterinary medicine and have recently entered the clinical realm as immunotherapies for cancer. We present a comprehensive method for producing high-quality lots of the poxvirus P
Externí odkaz:
https://doaj.org/article/80ee3b897ec94e55bc1c335e48d70703
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jacob G. E. Yates, Lily Chan, Geoffrey A. Wood, Alicia M. Viloria-Petit, Khalil Karimi, James J. Petrik, Sarah K. Wootton, Byram W. Bridle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Novel immunotherapies continue to be developed and tested for application against a plethora of diseases. The clinical translation of immunotherapies requires an understanding of their mechanisms. The contributions of antibodies in driving long-term
Externí odkaz:
https://doaj.org/article/290daf6e1e214d409b2203e5bfe374a6
Autor:
Amanda W. K. AuYeung, Robert C. Mould, Ashley A. Stegelmeier, Jacob P. van Vloten, Khalil Karimi, J. Paul Woods, James J. Petrik, Geoffrey A. Wood, Byram W. Bridle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene
Externí odkaz:
https://doaj.org/article/cc74d8086b614168938f0bb79a7adef3
Autor:
Jacob P van Vloten, Kathy Matuszewska, Mark A A Minow, Jessica A Minott, Lisa A Santry, Madison Pereira, Ashley A Stegelmeier, Thomas M McAusland, Elaine M Klafuric, Khalil Karimi, Joseph Colasanti, D Grant McFadden, James J Petrik, Byram W Bridle, Sarah K Wootton
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Novel therapies are needed to improve outcomes for women diagnosed with ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic biologics that preferentially infect cancer cells and stimulate inflammation with the potential
Externí odkaz:
https://doaj.org/article/042f07917dda4af9ab08f790da95d074
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100070- (2022)
Polycyclic aromatic compounds (PACs) are a broad class of contaminants ubiquitously present in the environment due to natural and anthropogenic activities. With increasing industrialization and reliance on petroleum worldwide, PACs are increasingly b
Externí odkaz:
https://doaj.org/article/33000d7f4f8548c4bc4d918901de624b
Autor:
Jacob P. van Vloten, Lisa A. Santry, Thomas M. McAusland, Khalil Karimi, Grant McFadden, James J. Petrik, Sarah K. Wootton, Byram W. Bridle
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 154-166 (2019)
Immunotherapies are at the forefront of the fight against cancers, and researchers continue to develop and test novel immunotherapeutic modalities. Ideal cancer immunotherapies induce a patient’s immune system to kill their own cancer and develop l
Externí odkaz:
https://doaj.org/article/aabcd172c9ad4c789fec25d5700601e1
Autor:
Ashley A. Stegelmeier, Lisa A. Santry, Matthew M. Guilleman, Kathy Matuszewska, Jessica A. Minott, Jacob G. E. Yates, Brenna A. Y. Stevens, Sylvia P. Thomas, Sierra Vanderkamp, Kiersten Hanada, Yanlong Pei, Amira D. Rghei, Jacob P. van Vloten, Madison Pereira, Brad Thompson, Pierre P. Major, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 362 (2022)
Epithelial ovarian cancer is the deadliest gynecological malignancy. The lack of effective treatments highlights the need for novel therapeutic interventions. The aim of this study was to investigate whether sustained adeno-associated virus (AAV) vec
Externí odkaz:
https://doaj.org/article/b7a933055d294583b0ee729eeada2323