Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James J Monroe"'
Autor:
Sam V Machotka, Frank D. Sistare, Amy G. Aslamkhan, Alex M Tamburino, Todd Pippert, Raymond Evers, Kaushik Mitra, Keith Q. Tanis, Timothy E. Johnson, Donna Lynch, Wen Kang, Truyen Nguyen, Randy R. Miller, James J Monroe, Tamara D. Cabalu, Alexei A. Podtelezhnikov, Nancy G. B. Agrawal, Jairam Palamanda
Publikováno v:
Toxicological Sciences
Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabol
Autor:
James J. Monroe, Ian Knemeyer, Robert Houle, Andreas Baudy, Frank D. Sistare, Michael J. Hafey, Raymond Evers, Jackie Shang, Qing Chen, Keith Q. Tanis
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(11)
Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug-induced liver injury (DILI). To understand the relationship between BSEP inhibition and DIL
Autor:
José A. Lebrón, Frank D. Sistare, Qing Chen, Donald J Marsh, Matthew Kuhls, Timothy E. Johnson, Wen Kang, Zhibin Wang, George Laws, Kaushik Mitra, James J. Monroe, Keith Q. Tanis, Thomas G. Griffiths, Kimberly B. Bleicher, Ming Su, Alexei A. Podtelezhnikov, Stephen Pacchione, Ian Knemeyer
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S42
Autor:
Randy R. Miller, Todd Pippert, Timothy E. Johnson, Deborah Nicoll-Griffith, Amy G. Aslamkhan, Frank D. Sistare, Wendy J. Bailey, Sam Machotka Palamanda, Stephen Pacchione, Kaushik Mitra, Tamara D. Cabalu, Raymond Evers, Pierre Daublain, Keith Q. Tanis, Kathleen Cox, Truyen Nguyen, Warren E. Glaab, Nancy G. B. Agrawal, Alexei A. Podtelezhnikov, Donna Lynch, James J Monroe
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S36
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 476:1-11
The lacI transgene used in the Big Blue™ (BB) mouse and rat mutation assays typically displays spontaneous mutation frequencies in the 5×10 −5 range. Recently, the bone marrow and bladder of the Big Blue™ rat were reported to have, by an order
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 421:121-136
We have compared the response of the native hprt gene and the lacI , cII , and cI transgenes in Big Blue™ B6C3F1 mice following treatment with either N -nitroso- N -methylurea (MNU) or benzo[ a ]pyrene (B a P). Three weeks after mutagen treatment s
Autor:
Armen H. Tashjian, James J. Monroe
Publikováno v:
Biochemical and Biophysical Research Communications. 225:320-325
Parathyroid hormone (PTH)-stimulated production of cAMP by intact human osteoblast-like SaOS-2 cells is diminished by pretreatment with 17β-estradiol (E 2 ). The goal of the present study was to determine whether E 2 affected adenylyl cyclase activi
Autor:
Michael A Oropallo, Jackie Shang, Zhenlian Ke, Raymond James Gonzalez, Frank D. Sistare, Jose Lebron, James J. Monroe
Publikováno v:
The Journal of Immunology. 196:194.10-194.10
Idiosyncratic drug induced hypersensitivy reactions (IDHR)s pose a significant safety risk to patients. Indeed, IDHRs have been associated with severe, life-threatening conditions such as Stevens Johnson syndrome, Toxic epidermal necrolysis, and hepa
Publikováno v:
Mutation research. 430(1)
The ability to detect DNA sequence heterogeneity quickly and reliably is becoming increasingly important as more genes involved in disease processes are discovered. We have assessed the ability of a high pressure liquid chromatography technique (HPLC
Autor:
Hafey MJ; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey michael_hafey@merck.com., Houle R; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Tanis KQ; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Knemeyer I; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Shang J; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Chen Q; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Baudy A; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Monroe J; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Sistare FD; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey., Evers R; Departments of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) (M.J.H., R.H., I.K., J.S., Q.C., R.E.), Genetics and Pharmacogenomics (K.Q.T.), and Safety Assessment and Laboratory Animal Resources (SALAR) (A.B., J.M., F.D.S.), Merck & Co., Inc., Kenilworth, New Jersey.
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 Nov; Vol. 48 (11), pp. 1147-1160. Date of Electronic Publication: 2020 Sep 17.