Zobrazeno 1 - 10
of 359
pro vyhledávání: '"James J Lah"'
Autor:
Zifan Jiang, Salman Seyedi, Rafi U Haque, Alvince L Pongos, Kayci L Vickers, Cecelia M Manzanares, James J Lah, Allan I Levey, Gari D Clifford
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262527 (2022)
Differences in expressing facial emotions are broadly observed in people with cognitive impairment. However, these differences have been difficult to objectively quantify and systematically evaluate among people with cognitive impairment across disea
Externí odkaz:
https://doaj.org/article/e8fb4387b4ad4e79bbbab517cc255712
Autor:
Mfon E Umoh, Eric B Dammer, Jingting Dai, Duc M Duong, James J Lah, Allan I Levey, Marla Gearing, Jonathan D Glass, Nicholas T Seyfried
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 48-62 (2017)
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases with overlap in clinical presentation, neuropathology, and genetic underpinnings. The molecular basis for the overlap of these disorders is
Externí odkaz:
https://doaj.org/article/b8b7499dd4d9446c941b6c08b5f8bee4
Autor:
William T Hu, Matthew Shelnutt, Ashley Wilson, Nicole Yarab, Crystal Kelly, Murray Grossman, David J Libon, Jaffar Khan, James J Lah, Allan I Levey, Jonathan Glass
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57584 (2013)
It is difficult to longitudinally characterize cognitive impairment in amyotrophic lateral sclerosis (ALS) due to motor deficits, and existing instruments aren't comparable with assessments in other dementias.The ALS Brief Cognitive Assessment (ALS-B
Externí odkaz:
https://doaj.org/article/c9245e48d11f430abc56eeb9c2728539
Autor:
Eric B Dammer, Claudia Fallini, Yair M Gozal, Duc M Duong, Wilfried Rossoll, Ping Xu, James J Lah, Allan I Levey, Junmin Peng, Gary J Bassell, Nicholas T Seyfried
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38658 (2012)
TAR DNA-binding protein 43 (TDP-43) is a major component within ubiquitin-positive inclusions of a number of neurodegenerative diseases that increasingly are considered as TDP-43 proteinopathies. Identities of other inclusion proteins associated with
Externí odkaz:
https://doaj.org/article/9cf44cf929ca48b18b142527619bc7da
Autor:
Kristen L Sager, Joanne Wuu, Jeremy H Herskowitz, Elliott J Mufson, Allan I Levey, James J Lah
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e40527 (2012)
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Because the pathological changes underlying this disease can begin decades prior to the onset of cognitive impairment, identifying the earliest events in the AD pathological ca
Externí odkaz:
https://doaj.org/article/ac90c35e1ded45248b977ceff858565a
Publikováno v:
Journal of Alzheimer's Disease. 92:411-424
Background: The complex and not yet fully understood etiology of Alzheimer’s disease (AD) shows important proteopathic signs which are unlikely to be linked to a single protein. However, protein subsets from deep proteomic datasets can be useful in
Autor:
Marta del Campo, Carel F. W. Peeters, Erik C. B. Johnson, Lisa Vermunt, Yanaika S. Hok-A-Hin, Mirrelijn van Nee, Alice Chen-Plotkin, David J. Irwin, William T. Hu, James J. Lah, Nicholas T. Seyfried, Eric B. Dammer, Gonzalo Herradon, Lieke H. Meeter, John van Swieten, Daniel Alcolea, Alberto Lleó, Allan I. Levey, Afina W. Lemstra, Yolande A. L. Pijnenburg, Pieter J. Visser, Betty M. Tijms, Wiesje M. van der Flier, Charlotte E. Teunissen
Publikováno v:
Nature aging, 2(11), 1040-+. Nature Publishing Group
del Campo, M, Peeters, C F W, Johnson, E C B, Vermunt, L, Hok-A-Hin, Y S, van Nee, M, Chen-Plotkin, A, Irwin, D J, Hu, W T, Lah, J J, Seyfried, N T, Dammer, E B, Herradon, G, Meeter, L H, van Swieten, J, Alcolea, D, Lleó, A, Levey, A I, Lemstra, A W, Pijnenburg, Y A L, Visser, P J, Tijms, B M, van der Flier, W M & Teunissen, C E 2022, ' CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels ', Nature Aging, vol. 2, no. 11, pp. 1040-1053 . https://doi.org/10.1038/s43587-022-00300-1
Nature Aging, 2(11), 1040-1053
Nature Aging, 2(11), 1040-1053. Springer
Nature Aging 2 (2022) 11
del Campo, M, Peeters, C F W, Johnson, E C B, Vermunt, L, Hok-A-Hin, Y S, van Nee, M, Chen-Plotkin, A, Irwin, D J, Hu, W T, Lah, J J, Seyfried, N T, Dammer, E B, Herradon, G, Meeter, L H, van Swieten, J, Alcolea, D, Lleó, A, Levey, A I, Lemstra, A W, Pijnenburg, Y A L, Visser, P J, Tijms, B M, van der Flier, W M & Teunissen, C E 2022, ' CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels ', Nature Aging, vol. 2, no. 11, pp. 1040-1053 . https://doi.org/10.1038/s43587-022-00300-1
Nature Aging, 2(11), 1040-1053
Nature Aging, 2(11), 1040-1053. Springer
Nature Aging 2 (2022) 11
Development of disease-modifying therapies against Alzheimer's disease (AD) requires biomarkers reflecting the diverse pathological pathways specific for AD. We measured 665 proteins in 797 cerebrospinal fluid (CSF) samples from patients with mild co
Autor:
Zifan Jiang, Salman Seyedi, Kayci L. Vickers, Cecelia M. Manzanares, James J. Lah, Allan I. Levey, Gari D. Clifford
Publikováno v:
medRxiv
ObjectiveCompared to individuals without cognitive impairment (CI), those with CI exhibit differences in both basic oculomotor functions and complex viewing behaviors. However, the characteristics of the differences and how those differences relate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eaba95b7b171cd0770f2f3ee4df1f89
https://europepmc.org/articles/PMC10246124/
https://europepmc.org/articles/PMC10246124/
Autor:
Thomas S, Wingo, Ekaterina S, Gerasimov, Se Min, Canon, James J, Lah, Allan I, Levey, Aliza P, Wingo
Publikováno v:
Alzheimer's & Dementia. 19:868-874
Despite an established link between depression and higher Alzheimer's disease (AD) risk, it is unclear whether the conditions share pathophysiology. Here, we investigated whether depression manifesting after age 50 is associated with a genetic predis
Publikováno v:
Magnetic Resonance in Medicine. 88:1624-1642